APBA2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APBA2_RAT
• UniProt AC: O35431
• Protein Name: Amyloid-beta A4 precursor protein-binding family A member 2
• Gene Name: Apba2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 750
• Protein Description: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta..
• Protein Sequence: MAHRKRQSTASSMLDHRARPGPIPHDQEPENEDTELPLESYVPTGLELGTLRPDSPTPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGVTYYIRYCPEDDSYLEGMDCNGEEYLAHGAHPVDTDECQEAVEDWTDSVGPHTHSHGAENSQEYPDSHLPIPEDDPTVLEVHDQEEDGHYCPSKESYQDYYPPETNGNTGGASPYRMRRGDGDLEEQEEDIDQIVAEIKMSLSMTSITSASEASPEHMPELDPGDSTEACSPSDTGRGPSRQEARPKSLNLPPEVKHSGDPQRGLKTKTRTPEERPKWPQEQVCNGLEQPRKQQRSDLNGPTDNNNIPETKKVASFPSFVAVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	RKRQSTASSMLDHRA CCCCCHHHHHHCCCC	19.17	-
209	Phosphorylation	NGNTGGASPYRMRRG CCCCCCCCCCCCCCC	26.24	-
307	Phosphorylation	GLKTKTRTPEERPKW CCCCCCCCHHHCCCC	40.04	25403869
479	Phosphorylation	ARRRMPRSASQDCIE CCCCCCCCCCCCCHH	26.80	27097102
481	Phosphorylation	RRMPRSASQDCIETT CCCCCCCCCCCHHCC	28.00	27097102
540	Phosphorylation	GINPEDLSQKEYSDI CCCHHHCCHHHHHHH	52.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APBA2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APBA2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APBA2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STXB1_RAT	Stxbp1	physical	9395480
STX1A_RAT	Stx1a	physical	9395480
GRASP_RAT	Grasp	physical	12586822

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.