GRASP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRASP_RAT
• UniProt AC: Q8R4T5
• Protein Name: General receptor for phosphoinositides 1-associated scaffold protein
• Gene Name: Grasp
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 394
• Subcellular Localization: Cytoplasm, perinuclear region . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse, postsynaptic cell membrane . Localized at postsynaptic membranes.
• Protein Description: Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses..
• Protein Sequence: MTLRRLRKLQQKEEATAAPDLAGRAPDSEAARAAPTPSGPPAAAAPPGAPGDELYAALEDYHPAELYRALAVSGGTLPRRKGSGFRWKNFTQSPEQQRKVLTLEKGDNQTFGFEIQTYGLHHREEQRVEMVTFVCRVHESSPAQLAGLTPGDTIASVNGLNVEGIRHREIVDIIKASGNVLRLETLYGTSIRKAELEARLQYLKQTLYEKWGEYRSLMVQEQRLVHGLVVKDPSIYDTLESVRSCLYGAGLLPGSLPFGPLLAAPGGARGGSRRAKGDTDDAVYHTCFFGGAEPQALPPPPPPARAPGPGSAETPASVLCPAPRATLSRSASVRCAGPGGGGGGGAPGALWTEAREQALCGAGLRKTKYRSFRRRLLKFIPGLNRSLEEEESQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	GAPGDELYAALEDYH CCCHHHHHHHHHHCC	6.43	-
67	Phosphorylation	DYHPAELYRALAVSG HCCHHHHHHHHHHCC	5.83	-
73	Phosphorylation	LYRALAVSGGTLPRR HHHHHHHCCCCCCCC	26.37	28432305
76	Phosphorylation	ALAVSGGTLPRRKGS HHHHCCCCCCCCCCC	36.79	28432305
91	Phosphorylation	GFRWKNFTQSPEQQR CCCCCCCCCCHHHHH	37.21	30181290
93	Phosphorylation	RWKNFTQSPEQQRKV CCCCCCCCHHHHHCE	27.61	27097102
187	Phosphorylation	VLRLETLYGTSIRKA EEEEEEECCCCCHHH	26.27	-
236	Phosphorylation	VVKDPSIYDTLESVR EECCCHHHHHHHHHH	13.76	-
238	Phosphorylation	KDPSIYDTLESVRSC CCCHHHHHHHHHHHH	18.56	25403869
241	Phosphorylation	SIYDTLESVRSCLYG HHHHHHHHHHHHHHC	26.41	25403869
269	Methylation	LAAPGGARGGSRRAK CCCCCCCCCCCCCCC	53.96	-
386	Phosphorylation	FIPGLNRSLEEEESQ HCCCCCCCHHHHHHC	38.77	22673903
392	Phosphorylation	RSLEEEESQL----- CCHHHHHHCC-----	39.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRASP_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRASP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRASP_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FRY_HUMAN	FRY	physical	12586822
CE170_HUMAN	CEP170	physical	12586822
GLU2B_HUMAN	PRKCSH	physical	12586822
ZHX1_HUMAN	ZHX1	physical	12586822
BCR_HUMAN	BCR	physical	12586822
FCSD2_HUMAN	FCHSD2	physical	12586822
ZBTB5_HUMAN	ZBTB5	physical	12586822
CEP83_HUMAN	CEP83	physical	12586822
CYH2_RAT	Cyth2	physical	12586822
AFF2_MOUSE	Aff2	physical	12586822
GRM1_RAT	Grm1	physical	11850456
GRM2_RAT	Grm2	physical	11850456
GRM3_RAT	Grm3	physical	11850456
GBRB2_RAT	Gabrb2	physical	11850456
GRM5_RAT	Grm5	physical	11850456

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.