GBRB2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRB2_RAT
• UniProt AC: P63138
• Protein Name: Gamma-aminobutyric acid receptor subunit beta-2
• Gene Name: Gabrb2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 474
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane .
• Protein Description: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel..
• Protein Sequence: MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	N-linked_Glycosylation	QSVNDPSNMSLVKET HHCCCCCHHHHHHHH	29.47	-
104	N-linked_Glycosylation	SYNVIPLNLTLDNRV CCEEEECEEEECCCH	26.14	-
173	N-linked_Glycosylation	RYPLDEQNCTLEIES CCCCCCCCCEEEEEE	20.77	-
396	Phosphorylation	PRSTMLAYDASSIQY CHHHHEEEEHHHHHH	14.21	-
403	Phosphorylation	YDASSIQYRKAGLPR EEHHHHHHHHCCCCC	16.65	-
434	Phosphorylation	SRLRRRASQLKITIP HHHHHHHHHCCCCCC	33.95	12818177

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
434	S	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRB2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRB2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GBRB2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.