AFF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AFF2_MOUSE
• UniProt AC: O55112
• Protein Name: AF4/FMR2 family member 2
• Gene Name: Aff2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1272
• Subcellular Localization: Nucleus speckle . When splicing or transcription are inhibited, accumulates in large, rounded speckles and in the nucleolus..
• Protein Description: RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure..
• Protein Sequence: MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEEDLFSSGFDLFGEPYKVAEYTNKGDALANRVQNTLGSYDEMKDLLSNHSSQNHLVGIPKNSAPQTPISKSEASFYPEQKNRMIPSHQETTHSSTPMPPPSVVILNSTLIHSNRKSKSEWPRDSHNTSPAQASQTSSQPNKMQTSTQDPPQTRLEDFFVYPAEQPQIGTVEKSNPSSKEENNPNSGGEDTFKEIFQSNSPEESEFTVQAPGSPLVASSLLAPSSGLSVPTFPPGLYCKTSMGQQKPTAYVRPMDGQDQATDISPTLKPSIEFENSFGNLSFGSLLDGKPSAVSSKTKLPKFTILQTSEVSLTSDPSCVEEILRESQHLTPGFTLQKWSDPSSRASTKMLEDDLKLSSDEDDLEPVKTLTTQCTANELYQAVEKAKPKNNPVNPLLATPQSTPATQTNVGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPTETISLPPPIIQPVEVQVKVKPNPSQAVAVPKERPLLSLIREKARPRPTQKTPETKALKHKLSTSVDTVSQRTIGKKQPKKVEKNTSFEEFTWPKPNITNSTPKEKGSVELPDPPRSRNKATAHKPVPRKEPRPHVPLATEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCITSKSKETSNASLTLSTLTNGNSNNLSTSNEETAFSPPPAMQTELLSPLRDHENPKNLWVKIDLDLLSRVPGQNSVPVTPAKTDYKETASKPKRQTAATAVEKPAPKGKRKHKPAETAEKIPEKKQRLEDNTTICLLPPCISPAPPHKPPSTRENSSRRANRKKEEKLFPPALSPLAEDPPRRRNVSGNNGHFGQDKNISMAGQITSSKPKRSEGKFCATFKGISINEGDAPKKAASATVTVANMALATATATATVPAIVTATVTATATTTATATTTTTTTTISSITPTITSGLMDSSHLEMTSWAALPLLSSSSANVRRPKLTFDDSVHNADFYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVTQIPSPWVGNGKNTPSPVSLNNVSPINSVGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRDNKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
167	Phosphorylation	PRDSHNTSPAQASQT CCCCCCCCHHHHHHC	24.45	27087446
341	Phosphorylation	KTKLPKFTILQTSEV CCCCCCEEEEECCEE	27.23	28494245
345	Phosphorylation	PKFTILQTSEVSLTS CCEEEEECCEEECCC	24.33	28494245
372	Phosphorylation	QHLTPGFTLQKWSDP CCCCCCCCCEECCCC	33.91	28059163
395	Phosphorylation	LEDDLKLSSDEDDLE HHHHHCCCCCCCCCH	33.87	26370283
396	Phosphorylation	EDDLKLSSDEDDLEP HHHHCCCCCCCCCHH	56.29	26370283
482	Phosphorylation	NEAPRVATPEPEPPS CCCCCCCCCCCCCCC	25.90	21995493
594	Acetylation	SQRTIGKKQPKKVEK HHHHCCCCCCCCCCC	67.62	21728379
625	Phosphorylation	STPKEKGSVELPDPP CCCCCCCCCCCCCCC	24.40	81111475
825	Acetylation	TAEKIPEKKQRLEDN HHHHCCHHHHHCCCC	49.18	19859029
875	Phosphorylation	KLFPPALSPLAEDPP HCCCCCCCCCCCCCC	21.70	82900365
888	Phosphorylation	PPRRRNVSGNNGHFG CCCCCCCCCCCCCCC	39.08	44695259
1083	Phosphorylation	RDPLEAKSPYTMYSE CCCCCCCCCCCHHHH	30.13	29550500
1085	Phosphorylation	PLEAKSPYTMYSETV CCCCCCCCCHHHHHH	15.95	29550500
1086	Phosphorylation	LEAKSPYTMYSETVE CCCCCCCCHHHHHHH	17.02	29550500
1088	Phosphorylation	AKSPYTMYSETVELL CCCCCCHHHHHHHHH	8.78	29550500
1089	Phosphorylation	KSPYTMYSETVELLR CCCCCHHHHHHHHHH	18.90	29550500

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AFF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AFF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AFF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AFF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.