| UniProt ID | CEP83_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y592 | |
| Protein Name | Centrosomal protein of 83 kDa | |
| Gene Name | CEP83 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 693 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to centrioles at all stages o | |
| Protein Description | Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly.. | |
| Protein Sequence | MDTFPNNFPPGGDSGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASINPVSFQSSAMVPSMELPFPPHMQEEQHQRELSLLRKRLEELETTQRKQLEELGSSGE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Phosphorylation | QTLKAEHTRLQNEHV HHHHHHHHHHHHHHH | - | ||
| 103 | Phosphorylation | EMKLQILTPQKLELL HHHHHHHCHHHHHHH | 21815630 | ||
| 111 | Phosphorylation | PQKLELLRAQIQQEL HHHHHHHHHHHHHHC | - | ||
| 172 | Phosphorylation | LDEGKIKYESEIARL HHHCCCCHHHHHHHH | 21712546 | ||
| 180 | Phosphorylation | ESEIARLEEDKEELR HHHHHHHHHCHHHHH | - | ||
| 191 | Ubiquitination | EELRNQLLNVDLTKD HHHHHHHHCCCCCCC | - | ||
| 196 | Phosphorylation | QLLNVDLTKDSKRVE HHHCCCCCCCCHHHH | 19367720 | ||
| 204 | Phosphorylation | KDSKRVEQLAREKVY CCCHHHHHHHHHHHH | - | ||
| 280 | Phosphorylation | EKELQSSSEQNTFLI HHHHHCCHHHHHHHH | - | ||
| 326 | Acetylation | KLETARAKSELERER HHHHHHHHHHHHHHH | 15611947 | ||
| 338 | Phosphorylation | RERNKIQSELDGLQS HHHHHHHHHHHHHHC | 28450419 | ||
| 343 | Ubiquitination | IQSELDGLQSDNEIL HHHHHHHHHCCHHHH | - | ||
| 345 | Phosphorylation | SELDGLQSDNEILKA HHHHHHHCCHHHHHH | 28450419 | ||
| 507 | Phosphorylation | QECRNFRSQAEKAQL HHHHHHHHHHHHHHH | 30242111 | ||
| 545 | Phosphorylation | ITDREEKYNQAKEKL HHHHHHHHHHHHHHH | 22673903 | ||
| 553 | Phosphorylation | NQAKEKLQRAAIAQK HHHHHHHHHHHHHHH | - | ||
| 633 | Phosphorylation | LVPNMPPTASINPVS ECCCCCCCCCCCCCC | 25332170 | ||
| 644 | Phosphorylation | NPVSFQSSAMVPSME CCCCCCCCCCCCCCC | 25332170 | ||
| 668 | Phosphorylation | EQHQRELSLLRKRLE HHHHHHHHHHHHHHH | 23186163 | ||
| 676 | Phosphorylation | LLRKRLEELETTQRK HHHHHHHHHHHHHHH | - | ||
| 690 | Phosphorylation | KQLEELGSSGE---- HHHHHHHCCCC---- | 30108239 | ||
| 691 | Phosphorylation | QLEELGSSGE----- HHHHHHCCCC----- | 30108239 | ||
| 698 | Phosphorylation | SGE------------ CCC------------ | - | ||
| 699 | Phosphorylation | GE------------- CC------------- | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CEP83_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CEP83_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CEP83_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CEP83_HUMAN | CEP83 | physical | 25416956 | |
| NEDD1_HUMAN | NEDD1 | physical | 26638075 | |
| PALLD_HUMAN | PALLD | physical | 26638075 | |
| SCN3A_HUMAN | SCN3A | physical | 26638075 | |
| SHLB2_HUMAN | SH3GLB2 | physical | 26638075 | |
| P63_HUMAN | TP63 | physical | 26638075 | |
| BTBDB_HUMAN | BTBD11 | physical | 26638075 | |
| DVL1_HUMAN | DVL1 | physical | 26638075 | |
| MS18A_HUMAN | MIS18A | physical | 26638075 | |
| POTB2_HUMAN | POTEB2 | physical | 28514442 | |
| POTEC_HUMAN | POTEC | physical | 28514442 | |
| UBP7_HUMAN | USP7 | physical | 28514442 | |
| CKAP5_HUMAN | CKAP5 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| 615862 | Nephronophthisis 18 (NPHP18) | |||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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