GRM2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM2_RAT
• UniProt AC: P31421
• Protein Name: Metabotropic glutamate receptor 2
• Gene Name: Grm2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 872
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite.
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization..
• Protein Sequence: MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
203	N-linked_Glycosylation	AEILRFFNWTYVSTV HHHHHHCCCEEEEEE	27.71	-
286	N-linked_Glycosylation	LAATQRLNASFTWVA HHHHHHHHCEEEEEE	35.41	-
338	N-linked_Glycosylation	FQSLDPWNNSRNPWF HHHCCCCCCCCCHHH	41.82	-
402	N-linked_Glycosylation	MHRALCPNTTHLCDA HHHHHCCCCHHHHHC	57.52	-
547	N-linked_Glycosylation	CGLGYWPNASLTGCF CCCCCCCCCCEECCE	28.19	-
675	Phosphorylation	AQRPRFISPASQVAI CCCCCCCCHHHHHHH	16.23	22817900
843	Phosphorylation	GSAAPRASANLGQGS CCCCCCHHCCCCCCC	20.97	22817900
867	Phosphorylation	NGREVVDSTTSSL-- CCEEEECCCCCCC--	23.21	28551015
868	Phosphorylation	GREVVDSTTSSL--- CEEEECCCCCCC---	26.66	28551015
869	Phosphorylation	REVVDSTTSSL---- EEEECCCCCCC----	21.92	28551015
870	Phosphorylation	EVVDSTTSSL----- EEECCCCCCC-----	29.72	28551015
871	Phosphorylation	VVDSTTSSL------ EECCCCCCC------	35.69	28551015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
675	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
843	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
843	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RANB9_HUMAN	RANBP9	physical	18555800
KCC2A_RAT	Camk2a	physical	15494036
GRASP_RAT	Grasp	physical	11850456

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.