dbPTM

SNP23_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SNP23_MOUSE
UniProt AC	O09044
Protein Name	Synaptosomal-associated protein 23
Gene Name	Snap23
Organism	Mus musculus (Mouse).
Sequence Length	210
Subcellular Localization	Cell membrane Peripheral membrane protein. Cell membrane Lipid-anchor. Cell junction, synapse, synaptosome. Mainly localized to the plasma membrane.
Protein Description	Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion..
Protein Sequence	MDNLSPEEVQLRAHQVTDESLESTRRILGLAIESQDAGIKTITMLDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCICPCNRTKNFESGKNYKATWGDGGDNSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDNLSPEE -------CCCCCHHH	7.51	-
5	Phosphorylation	---MDNLSPEEVQLR ---CCCCCHHHHHHH	36.20	26643407
17	Phosphorylation	QLRAHQVTDESLEST HHHHHHCCHHHHHHH	27.72	25619855
20	Phosphorylation	AHQVTDESLESTRRI HHHCCHHHHHHHHHH	40.00	26824392
23	Phosphorylation	VTDESLESTRRILGL CCHHHHHHHHHHHHH	32.29	20469934
24	Phosphorylation	TDESLESTRRILGLA CHHHHHHHHHHHHHH	18.00	25619855
34	Phosphorylation	ILGLAIESQDAGIKT HHHHHHHCCCCCCEE	27.52	19144319
40	Ubiquitination	ESQDAGIKTITMLDE HCCCCCCEEEEEEHH	32.72	-
64	Ubiquitination	EGMDQINKDMREAEK HHHHHHHHHHHHHHH	55.31	-
71	Ubiquitination	KDMREAEKTLTELNK HHHHHHHHHHHHHHH	56.75	-
72	Phosphorylation	DMREAEKTLTELNKC HHHHHHHHHHHHHHH	30.34	28066266
74	Phosphorylation	REAEKTLTELNKCCG HHHHHHHHHHHHHCC	43.59	28066266
79	S-palmitoylation	TLTELNKCCGLCICP HHHHHHHHCCEEEEE	1.85	10085154
80	S-palmitoylation	LTELNKCCGLCICPC HHHHHHHCCEEEEEC	5.07	10085154
83	S-palmitoylation	LNKCCGLCICPCNRT HHHHCCEEEEECCCC	1.50	10085154
85	S-palmitoylation	KCCGLCICPCNRTKN HHCCEEEEECCCCCC	2.83	10085154
87	S-palmitoylation	CGLCICPCNRTKNFE CCEEEEECCCCCCCC	4.70	-
91	Ubiquitination	ICPCNRTKNFESGKN EEECCCCCCCCCCCC	57.30	-
95	Phosphorylation	NRTKNFESGKNYKAT CCCCCCCCCCCCCCC	51.43	27742792
99	Phosphorylation	NFESGKNYKATWGDG CCCCCCCCCCCCCCC	12.89	26643407
100	Ubiquitination	FESGKNYKATWGDGG CCCCCCCCCCCCCCC	49.05	-
102	Phosphorylation	SGKNYKATWGDGGDN CCCCCCCCCCCCCCC	26.31	24925903
110	Phosphorylation	WGDGGDNSPSNVVSK CCCCCCCCCCCCCCC	34.15	24925903
112	Phosphorylation	DGGDNSPSNVVSKQP CCCCCCCCCCCCCCC	41.92	25521595
116	Phosphorylation	NSPSNVVSKQPSRIT CCCCCCCCCCCCCCC	22.69	25521595
117	Ubiquitination	SPSNVVSKQPSRITN CCCCCCCCCCCCCCC	55.40	-
120	Phosphorylation	NVVSKQPSRITNGQP CCCCCCCCCCCCCCC	33.54	23684622
121	Phosphorylation	VVSKQPSRITNGQPQ CCCCCCCCCCCCCCC	46.57	24719451
123	Phosphorylation	SKQPSRITNGQPQQT CCCCCCCCCCCCCCC	31.99	24704852
127	Phosphorylation	SRITNGQPQQTTGAA CCCCCCCCCCCCCCC	29.64	24719451
130	Phosphorylation	TNGQPQQTTGAASGG CCCCCCCCCCCCCCC	23.19	28285833
135	Phosphorylation	QQTTGAASGGYIKRI CCCCCCCCCCCEEEC	32.01	25159016
138	Phosphorylation	TGAASGGYIKRITND CCCCCCCCEEECCCC	13.54	25159016
143	Phosphorylation	GGYIKRITNDAREDE CCCEEECCCCCCHHH	30.95	25338131
156	Phosphorylation	DEMEENLTQVGSILG HHHHHHHHHHHHHHH	32.56	25159016
160	Phosphorylation	ENLTQVGSILGNLKN HHHHHHHHHHHHHHH	18.78	21082442
185	Ubiquitination	AQNQQIQKITEKADT HHHHHHHHHHHHHCC	53.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
95	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
95	S	Phosphorylation	Kinase	IKKB	O88351	PSP
120	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
120	S	Phosphorylation	Kinase	IKKB	O88351	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SNP23_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SNP23_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX1A_HUMAN	STX1A	physical	9168999
STX2_HUMAN	STX2	physical	9168999
STX3_HUMAN	STX3	physical	9168999
STX4_HUMAN	STX4	physical	9168999
IKKA_MOUSE	Chuk	physical	23960234
IKKB_MOUSE	Ikbkb	physical	23960234
IKKB_HUMAN	IKBKB	physical	18692471
STX1A_MOUSE	Stx1a	physical	24705552
VAMP2_MOUSE	Vamp2	physical	24705552

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SNP23_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-34 AND SER-110,AND MASS SPECTROMETRY.	19144319 [Abstract]
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, AND MASSSPECTROMETRY.	18630941 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line."; Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.; Mol. Cell. Proteomics 3:279-286(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112, AND MASSSPECTROMETRY.	14729942 [Abstract]