STX17_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STX17_RAT
• UniProt AC: Q9Z158
• Protein Name: Syntaxin-17 {ECO:0000303|PubMed:10930465}
• Gene Name: Stx17 {ECO:0000250|UniProtKB:P56962}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 301
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Smooth endoplasmic reticulum membrane ; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, autopha
• Protein Description: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity)..
• Protein Sequence: MSEDEEKVKLRRLEPAIQKFTKIVIPTDLERLKKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNIREMEKLCLKVHKDDLILLKRMIDPMKEAAAAATAEFLQLHLESVEELKKQVKNEEALLQPSLTRSTTIDGVHTGEAEAASQSLTQIYALPEIPRDQNAAESWETLEADLIELSHLVTDMSLLVNSQQEKIDSIADHVNSAAVNVEEGTKNLQKAAKYKLAALPVAGAVIGGVVGGPIGLLAGFKVAGIAAALGGGVLGFTGGKLIQRRKQKMMEKLTSSCPDLPSQSDKKCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSEDEEKVK ------CCHHHHHHH	54.47	-
2	Phosphorylation	------MSEDEEKVK ------CCHHHHHHH	54.47	25575281
41	Acetylation	KHQINIEKYQRCRIW HCCCCHHHHHHHCHH	42.77	-
136	Phosphorylation	PSLTRSTTIDGVHTG CCCCCCCCCCCCCCC	20.51	30181290
142	Phosphorylation	TTIDGVHTGEAEAAS CCCCCCCCCCHHHHH	34.02	30181290
149	Phosphorylation	TGEAEAASQSLTQIY CCCHHHHHHCHHHHH	27.61	30181290
151	Phosphorylation	EAEAASQSLTQIYAL CHHHHHHCHHHHHHC	30.78	30181290
153	Phosphorylation	EAASQSLTQIYALPE HHHHHCHHHHHHCCC	20.40	30181290
156	Phosphorylation	SQSLTQIYALPEIPR HHCHHHHHHCCCCCC	7.71	23006999
286	Phosphorylation	QKMMEKLTSSCPDLP HHHHHHHHHCCCCCC	29.66	27097102
287	Phosphorylation	KMMEKLTSSCPDLPS HHHHHHHHCCCCCCC	40.14	27097102
288	Phosphorylation	MMEKLTSSCPDLPSQ HHHHHHHCCCCCCCC	25.16	27097102
294	Phosphorylation	SSCPDLPSQSDKKCS HCCCCCCCCCCCCCC	50.00	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
156	Y	Phosphorylation	Kinase	ABL1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STX17_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STX17_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of STX17_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.