ARAF_RAT - dbPTM
ARAF_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARAF_RAT
UniProt AC P14056
Protein Name Serine/threonine-protein kinase A-Raf
Gene Name Araf
Organism Rattus norvegicus (Rat).
Sequence Length 604
Subcellular Localization
Protein Description Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity)..
Protein Sequence MEPPRGPPASGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEVPSNLSVNELLTPQGPSPFTQQRDQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTDAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPAEQRERKSLADEKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationPASGAEPSRAVGTVK
CCCCCCCCCCEEEEE		25.1122673903
42PhosphorylationVRDGMSVYDSLDKAL
EECCCCHHHCHHHHH		7.78-
148PhosphorylationPTVCVDMSTNRRQFY
CEEEEECCCCCHHHH		20.3326022182
155PhosphorylationSTNRRQFYHSIQDLS
CCCCHHHHHHHHCCC		6.0623984901
157PhosphorylationNRRQFYHSIQDLSGG
CCHHHHHHHHCCCCC		15.5727097102
162PhosphorylationYHSIQDLSGGSRQQE
HHHHHCCCCCCCCCC		49.7727097102
165PhosphorylationIQDLSGGSRQQEVPS
HHCCCCCCCCCCCCC		30.3727097102
172PhosphorylationSRQQEVPSNLSVNEL
CCCCCCCCCCCHHHC		56.4223984901
175PhosphorylationQEVPSNLSVNELLTP
CCCCCCCCHHHCCCC		27.4423984901
181PhosphorylationLSVNELLTPQGPSPF
CCHHHCCCCCCCCCC		26.6227097102
186PhosphorylationLLTPQGPSPFTQQRD
CCCCCCCCCCCCCCC		39.2027097102
189PhosphorylationPQGPSPFTQQRDQEH
CCCCCCCCCCCCCCC		27.4627097102
198PhosphorylationQRDQEHFSFPAPANP
CCCCCCCCCCCCCCC		32.0325575281
212PhosphorylationPPLQRIRSTSTPNVH
CCHHHHCCCCCCCEE		25.0827097102
213PhosphorylationPLQRIRSTSTPNVHM
CHHHHCCCCCCCEEE		27.1127097102
214PhosphorylationLQRIRSTSTPNVHMV
HHHHCCCCCCCEEEE		43.0127097102
215PhosphorylationQRIRSTSTPNVHMVS
HHHCCCCCCCEEEEE		20.9727097102
222PhosphorylationTPNVHMVSTTAPMDS
CCCEEEEEECCCCCC		16.6827097102
223PhosphorylationPNVHMVSTTAPMDSS
CCEEEEEECCCCCCH		18.6327097102
224PhosphorylationNVHMVSTTAPMDSSL
CEEEEEECCCCCCHH		22.6623984901
229PhosphorylationSTTAPMDSSLMQFTA
EECCCCCCHHHHHHH		21.0823984901
230PhosphorylationTTAPMDSSLMQFTAQ
ECCCCCCHHHHHHHH		24.4823984901
235PhosphorylationDSSLMQFTAQSFSTD
CCHHHHHHHHCCCCC		13.5923984901
238PhosphorylationLMQFTAQSFSTDAAG
HHHHHHHCCCCCCCC		20.7823984901
240PhosphorylationQFTAQSFSTDAAGRG
HHHHHCCCCCCCCCC		30.5328689409
241PhosphorylationFTAQSFSTDAAGRGG
HHHHCCCCCCCCCCC		27.8728689409
255PhosphorylationGDGAPRGSPSPASVS
CCCCCCCCCCCCCCC		24.3929779826
257PhosphorylationGAPRGSPSPASVSSG
CCCCCCCCCCCCCCC		34.4922108457
260PhosphorylationRGSPSPASVSSGRKS
CCCCCCCCCCCCCCC		26.3925575281
262PhosphorylationSPSPASVSSGRKSPH
CCCCCCCCCCCCCCC		25.2825575281
263PhosphorylationPSPASVSSGRKSPHS
CCCCCCCCCCCCCCC		40.2225575281
267PhosphorylationSVSSGRKSPHSKLPA
CCCCCCCCCCCCCCH		26.8723984901
270PhosphorylationSGRKSPHSKLPAEQR
CCCCCCCCCCCHHHH		38.9925575281
297PhosphorylationKNLGYRDSGYYWEVP
HHCCCCCCCCEEECC		21.5030181290
299PhosphorylationLGYRDSGYYWEVPPS
CCCCCCCCEEECCHH		14.9030181290
316PhosphorylationQLLKRIGTGSFGTVF
HHHHHHCCCCCCCEE		27.5523984901
318PhosphorylationLKRIGTGSFGTVFRG
HHHHCCCCCCCEECC		21.9723984901
321PhosphorylationIGTGSFGTVFRGRWH
HCCCCCCCEECCEEC		17.9223984901
578PhosphorylationSLPKIERSASEPSLH
HCHHHHHCCCCCCCC		24.2925403869
580PhosphorylationPKIERSASEPSLHRT
HHHHHCCCCCCCCCC		51.8123712012
583PhosphorylationERSASEPSLHRTQAD
HHCCCCCCCCCCCHH		32.5323984901
587PhosphorylationSEPSLHRTQADELPA
CCCCCCCCCHHHHHH		19.8423984901
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARAF_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARAF_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARAF_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ARAF_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARAF_RAT

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Related Literatures of Post-Translational Modification

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