dbPTM

RASN_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RASN_RAT
UniProt AC	Q04970
Protein Name	GTPase NRas
Gene Name	Nras
Organism	Rattus norvegicus (Rat).
Sequence Length	189
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side . Golgi apparatus membrane Lipid-anchor . Shuttles between the plasma membrane and the Golgi apparatus.
Protein Description	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity..
Protein Sequence	MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSEDGTQGCMGLPCVVM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	YDPTIEDSYRKQVVI CCCCCCHHHCCEEEE	17.66	30181290
89	Phosphorylation	FAINNSKSFADINLY EEECCCCCHHHHHHH	26.03	-
181	S-palmitoylation	SEDGTQGCMGLPCVV CCCCCCCCCCCCEEE	1.09	-
186	Methylation	QGCMGLPCVVM---- CCCCCCCEEEC----	4.30	-
186	Farnesylation	QGCMGLPCVVM---- CCCCCCCEEEC----	4.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RASN_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
89	S	Phosphorylation	-
Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.
104	K	Acetylation	-
Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
170	K	ubiquitylation	-
Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RASN_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RASN_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RASN_RAT

Related Literatures of Post-Translational Modification