PRS7_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRS7_RAT
• UniProt AC: Q63347
• Protein Name: 26S proteasome regulatory subunit 7
• Gene Name: Psmc2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 433
• Subcellular Localization: Cytoplasm . Colocalizes with TRIM5 in cytoplasmic bodies.
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides..
• Protein Sequence: MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIPVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Acetylation	YLGADQRKTKEDEKD CCCCCCCCCCCCCCC	59.31	22902405
13	Acetylation	GADQRKTKEDEKDDK CCCCCCCCCCCCCCC	67.23	22902405
34	Acetylation	EGDIALLKTYGQSTY HHCEEEEEHHCCCHH	40.32	22902405
110	Ubiquitination	NADSEDPKYIINVKQ ECCCCCCCEEEEHHH	62.49	-
116	Acetylation	PKYIINVKQFAKFVV CCEEEEHHHHHHHHE	34.90	22902405
116	Ubiquitination	PKYIINVKQFAKFVV CCEEEEHHHHHHHHE	34.90	-
340	Acetylation	RPGRLDRKIEFSLPD CCCCCCCEEEEECCC	46.37	22902405
356	Acetylation	EGRTHIFKIHARSMS CCCEEEEEEEECCCC	32.74	22902405
363	Phosphorylation	KIHARSMSVERDIRF EEEECCCCCCHHHHH	23.29	16396499
407	Acetylation	RRKIATEKDFLEAVN HHHCCCHHHHHHHHH	49.80	22902405
407	Ubiquitination	RRKIATEKDFLEAVN HHHCCCHHHHHHHHH	49.80	-
419	Phosphorylation	AVNKVIKSYAKFSAT HHHHHHHHHHCCCCC	21.14	25575281
420	Phosphorylation	VNKVIKSYAKFSATP HHHHHHHHHCCCCCC	14.60	25575281
422	Acetylation	KVIKSYAKFSATPRY HHHHHHHCCCCCCCC	31.45	-
424	Phosphorylation	IKSYAKFSATPRYMT HHHHHCCCCCCCCCC	30.44	25575281
426	Phosphorylation	SYAKFSATPRYMTYN HHHCCCCCCCCCCCC	13.70	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRS7_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRS7_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRS7_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS8_RAT	Psmc5	physical	10526239

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.