PRS8_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRS8_RAT
• UniProt AC: P62198
• Protein Name: 26S proteasome regulatory subunit 8
• Gene Name: Psmc5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 406
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides..
• Protein Sequence: MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALDGPEQM ------CCCCCHHHC	17.85	-
88	Acetylation	DKKKVLVKVHPEGKF CCCCEEEEEECCCCE	30.57	22902405
120	Phosphorylation	RVALRNDSYTLHKIL EEEECCCCEEHHHHC	24.46	22726833
194	Phosphorylation	LLYGPPGTGKTLLAR EEECCCCCCHHHHHH	41.08	23984901
197	Phosphorylation	GPPGTGKTLLARAVA CCCCCCHHHHHHHHH	28.48	23984901
222	Acetylation	SGSELVQKFIGEGAR CHHHHHHHHHHHHHH	31.31	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
120	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
120	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRS8_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRS8_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS6A_RAT	Psmc3	physical	10657252
PRS4_RAT	Psmc1	physical	10526239
PRS7_RAT	Psmc2	physical	10526239
KCC2A_HUMAN	CAMK2A	physical	20178748
GRM1_RAT	Grm1	physical	22486777
HOME3_RAT	Homer3	physical	22486777

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.