PRS6A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRS6A_RAT
• UniProt AC: Q63569
• Protein Name: 26S proteasome regulatory subunit 6A
• Gene Name: Psmc3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 439
• Subcellular Localization: Cytoplasm . Nucleus . Colocalizes with TRIM5 in cytoplasmic bodies.
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides..
• Protein Sequence: MNLLPTPESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIVQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNLLPTPE -------CCCCCCCC	7.81	-
6	Phosphorylation	--MNLLPTPESPVTR --CCCCCCCCCCCCH	39.39	23984901
9	Phosphorylation	NLLPTPESPVTRQEK CCCCCCCCCCCHHHH	26.35	23984901
12	Phosphorylation	PTPESPVTRQEKMAT CCCCCCCCHHHHHHH	29.98	27097102
16	Ubiquitination	SPVTRQEKMATVWDE CCCCHHHHHHHHHHH	26.04	-
37	Phosphorylation	GEEVLKMSTEEIVQR CHHHHHCCHHHHHHH	30.95	30181290
38	Phosphorylation	EEVLKMSTEEIVQRT HHHHHCCHHHHHHHH	33.85	30181290
53	Acetylation	RLLDSEIKIMKSEVL HHHHHHHHHCHHHHH	32.47	22902405
53	Ubiquitination	RLLDSEIKIMKSEVL HHHHHHHHHCHHHHH	32.47	-
146	Ubiquitination	LVDAEKLKPGDLVGV EEEHHHCCCCCEECC	59.01	-
211	Acetylation	LPMNHKEKFENLGIQ CCCCCHHHHHHCCCC	63.88	22902405
245	Ubiquitination	RACAAQTKATFLKLA HHHHHHCHHHHHHHH	33.09	-
276	Ubiquitination	RDAFALAKEKAPSII HHHHHHHHCCCCEEE	61.67	-
300	Acetylation	TKRFDSEKAGDREVQ CCCCCCCCCCCHHHH	62.72	22902405
376	Phosphorylation	HSRKMNVSPDVNYEE HHCCCCCCCCCCHHH	15.46	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRS6A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRS6A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRS6A_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RN19A_HUMAN	RNF19A	physical	19517565

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.