HOME3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOME3_RAT
• UniProt AC: Q9Z2X5
• Protein Name: Homer protein homolog 3 {ECO:0000305}
• Gene Name: Homer3 {ECO:0000312|RGD:620706}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 358
• Subcellular Localization: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Postsynaptic density of neuronal cells..
• Protein Description: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release (By similarity). Negatively regulates T cell activation through negative regulation of IL2 expression by inhibiting calcineurin-NFAT pathway activation through interaction with NFATC2 leading to reduction of interaction between NFATC2 and PPP3CA (By similarity)..
• Protein Sequence: MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFGSEQQLTQFAEKFQEVKEAARLAREKSQDGGELTSTALAMASHQVPPSPLVSTNGPEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNQRLAGALREANAAATQWRQQLEVQRAEAEHLRQRVAELEAQVAAEPVRAGEKEATSQSVEQLEARVQTKDQEIQTLKNQSTGPREAPDTAEREETQQQVQDLETRNAELEQQLRAMESNLEEARAERERARAEVGRAAQLLDVRLFELSELREGLARLAEAAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Phosphorylation	ARLAREKSQDGGELT HHHHHHHCCCCCCCH	28.84	27097102
127	Phosphorylation	SQDGGELTSTALAMA CCCCCCCHHHHHHHH	21.52	27097102
128	Phosphorylation	QDGGELTSTALAMAS CCCCCCHHHHHHHHC	25.06	27097102
129	Phosphorylation	DGGELTSTALAMASH CCCCCHHHHHHHHCC	22.06	27097102
135	Phosphorylation	STALAMASHQVPPSP HHHHHHHCCCCCCCC	11.02	30181290
156	Phosphorylation	PEEKLFRSQSADAPG HHHHHHCCCCCCCCC	22.58	23984901
158	Phosphorylation	EKLFRSQSADAPGPT HHHHCCCCCCCCCCC	29.39	23712012
175	Phosphorylation	ERLKKMLSEGSVGEV HHHHHHHHCCCCCEE	36.09	27097102
178	Phosphorylation	KKMLSEGSVGEVQWE HHHHHCCCCCEEEEE	23.93	27097102
250	Phosphorylation	RAGEKEATSQSVEQL CCCCCCCCHHCHHHH	28.52	30181290
251	Phosphorylation	AGEKEATSQSVEQLE CCCCCCCHHCHHHHH	27.75	30181290
253	Phosphorylation	EKEATSQSVEQLEAR CCCCCHHCHHHHHHH	27.65	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HOME3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOME3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOME3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRM1_RAT	Grm1	physical	9808458
GRM1_RAT	Grm1	physical	22486777
PRS8_RAT	Psmc5	physical	22486777

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.