PRS4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRS4_RAT
• UniProt AC: P62193
• Protein Name: 26S proteasome regulatory subunit 4
• Gene Name: Psmc1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 440
• Subcellular Localization: Cytoplasm. Nucleus. Membrane ; Lipid-anchor .
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides..
• Protein Sequence: MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGQSQSGGH ------CCCCCCCCC	35.53	-
4	Phosphorylation	----MGQSQSGGHGP ----CCCCCCCCCCC	22.15	-
24	Succinylation	DDKDKKKKYEPPVPT CCCCHHHCCCCCCCC	64.82	26843850
53	Phosphorylation	ASKLPLVTPHTQCRL HHCCCCCCCCCHHHH	19.62	25403869
61	Acetylation	PHTQCRLKLLKLERI CCCHHHHHHHHHHHH	32.21	22902405
86	Succinylation	IRNQEQMKPLEEKQE HHCHHHCCCHHHHHH	46.26	26843850
98	Acetylation	KQEEERSKVDDLRGT HHHHHHHCHHHHCCC	56.77	22902405
98	Ubiquitination	KQEEERSKVDDLRGT HHHHHHHCHHHHCCC	56.77	-
184	Phosphorylation	EKAPQETYADIGGLD EECCCCHHHCCCCCH	11.09	22276854
258	Acetylation	VGSELIQKYLGDGPK HCHHHHHHHHCCCHH	35.13	22902405
430	Ubiquitination	KENVLYKKQEGTPEG HHHCEEECCCCCCCC	39.77	-
434	Phosphorylation	LYKKQEGTPEGLYL- EEECCCCCCCCCCC-	19.88	23984901
439	Phosphorylation	EGTPEGLYL------ CCCCCCCCC------	22.63	22276854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRS4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRS4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRS4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS8_RAT	Psmc5	physical	10526239

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.