RAB7A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB7A_RAT
• UniProt AC: P09527
• Protein Name: Ras-related protein Rab-7a
• Gene Name: Rab7a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 207
• Subcellular Localization: Cytoplasmic vesicle, phagosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Melanosome membrane
• Protein Description: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By similarity). Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses (By similarity). Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium) (By similarity). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. [PubMed: 16040606 Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA]
• Protein Sequence: MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNERAKASAESCSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTSRKKVLL ------CCCHHHEEE	36.92	-
32	Acetylation	MNQYVNKKFSNQYKA HHHHHHHHHCHHHCC	49.15	22902405
72	Phosphorylation	AGQERFQSLGVAFYR CCHHHHHHHCCCHHC	25.12	29779826
111	Phosphorylation	DEFLIQASPRDPENF CEEEEECCCCCCCCC	12.23	27097102
168	Phosphorylation	NVEQAFQTIARNALK CHHHHHHHHHHHHHH	15.34	27097102
183	Phosphorylation	QETEVELYNEFPEPI HCCEEEHHHCCCCCC	10.11	27097102
205	Geranylgeranylation	AKASAESCSC----- HHHHHHHCCC-----	3.47	-
207	Methylation	ASAESCSC------- HHHHHCCC-------	8.30	-
207	Geranylgeranylation	ASAESCSC------- HHHHHCCC-------	8.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB7A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB7A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB7A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB7A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.