SH2B3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SH2B3_RAT
• UniProt AC: P50745
• Protein Name: SH2B adapter protein 3
• Gene Name: Sh2b3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 368
• Protein Description: Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase..
• Protein Sequence: MAGRTQGKHRPRVRTCPSLVPFDNPCWPPSHQPLPLQVGAPGHRVTSFLSGRAWPSYIPKGKHGLPGPRYVPDPWSLGVLGHVAPLRVTTTIFLPGASPGVMLDPACQKTDHFLSCYPWFHGPISRVRAAQLVQLQGPDAHGVFLVRQSESRRGEYVLTFNLQGRAKHLRLVLTERGQCRVQHLHFPSVVDMLRHFQRSPIPLECGAACDVRLSGYVVVVSQAPGRKPKVVSRGGVTASTARTKLPSWLRLLHGVIHVISPGSSNTVLFPFSLPHWDSELGHPHLSSAGCPPGHGAEALRGQVTPPEQIFHLVPSPEELANSLRQLELESVSSARDSDYEMDSSSRSHLRAIDNQYTPLSQLCREANL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67 (in isoform 3)	Phosphorylation	-	25.10	27097102
68 (in isoform 3)	Phosphorylation	-	23.61	27097102
70 (in isoform 3)	Phosphorylation	-	21.33	27097102
76 (in isoform 3)	Phosphorylation	-	22.19	27097102
304	Phosphorylation	EALRGQVTPPEQIFH HHHCCCCCCHHHHHE	25.82	23984901
356	Phosphorylation	LRAIDNQYTPLSQLC HHHHHCCCCCHHHHH	19.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SH2B3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SH2B3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SH2B3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH2B1_RAT	Sh2b1	physical	22028877
NTRK1_RAT	Ntrk1	physical	22028877

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.