PGFRA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGFRA_MOUSE
• UniProt AC: P26618
• Protein Name: Platelet-derived growth factor receptor alpha
• Gene Name: Pdgfra
• Organism: Mus musculus (Mouse).
• Sequence Length: 1089
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. The activated receptor is rapidly internalized and degraded..
• Protein Description: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor..
• Protein Sequence: MGTSHQVFLVLSCLLTGPGLISCQLLLPSILPNENEKIVQLNSSFSLRCVGESEVSWQHPMSEEDDPNVEIRSEENNSGLFVTVLEVVNASAAHTGWYTCYYNHTQTDESEIEGRHIYIYVPDPDMAFVPLGMTDSLVIVEEDDSAIIPCRTTDPETQVTLHNNGRLVPASYDSRQGFNGTFSVGPYICEATVKGRTFKTSEFNVYALKATSELNLEMDARQTVYKAGETIVVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPSIKLVYTLTVPKATVKDSGEYECAARQATKEVKEMKRVTISVHEKGFVEIEPTFGQLEAVNLHEVREFVVEVQAYPTPRISWLKDNLTLIENLTEITTDVQKSQETRYQSKLKLIRAKEEDSGHYTIIVQNEDDVKSYTFELSTLVPASILDLVDDHHGSGGGQTVRCTAEGTPLPEIDWMICKHIKKCNNDTSWTVLASNVSNIITELPRRGRSTVEGRVSFAKVEETIAVRCLAKNNLSVVARELKLVAPTLRSELTVAAAVLVLLVIVIVSLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFMSQHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDDSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	N-linked_Glycosylation	NEKIVQLNSSFSLRC CCCEEECCCCEEEEE	20.65	-
44	Phosphorylation	KIVQLNSSFSLRCVG CEEECCCCEEEEEEE	20.13	22942356
46	Phosphorylation	VQLNSSFSLRCVGES EECCCCEEEEEEECC	19.49	22942356
76	N-linked_Glycosylation	VEIRSEENNSGLFVT CEEEECCCCCCEEEE	43.87	-
89	N-linked_Glycosylation	VTVLEVVNASAAHTG EEEEEEHHHHHHHCC	33.10	-
103	N-linked_Glycosylation	GWYTCYYNHTQTDES CEEEEEECCCCCCHH	12.78	-
171	Phosphorylation	NGRLVPASYDSRQGF CCEEEECCCCCCCCC	24.33	22871156
172	Phosphorylation	GRLVPASYDSRQGFN CEEEECCCCCCCCCC	21.75	22871156
174	Phosphorylation	LVPASYDSRQGFNGT EEECCCCCCCCCCCE	20.47	22871156
179	N-linked_Glycosylation	YDSRQGFNGTFSVGP CCCCCCCCCEECCCC	56.25	-
259	Phosphorylation	EVRNKGITMLEEIKL CCCCCCEEEEEEECC	25.11	25177544
268	Phosphorylation	LEEIKLPSIKLVYTL EEEECCCCEEEEEEE	42.67	24719451
273	Phosphorylation	LPSIKLVYTLTVPKA CCCEEEEEEEECCCC	13.38	25177544
274	Phosphorylation	PSIKLVYTLTVPKAT CCEEEEEEEECCCCE	14.42	25177544
276	Phosphorylation	IKLVYTLTVPKATVK EEEEEEEECCCCEEC	27.28	-
281	Phosphorylation	TLTVPKATVKDSGEY EEECCCCEECCCCHH	33.93	-
353	N-linked_Glycosylation	RISWLKDNLTLIENL CCHHHHHHEEEEEHH	33.08	-
359	N-linked_Glycosylation	DNLTLIENLTEITTD HHEEEEEHHHHHCHH	45.31	-
361	Phosphorylation	LTLIENLTEITTDVQ EEEEEHHHHHCHHHH	36.60	25338131
365	Phosphorylation	ENLTEITTDVQKSQE EHHHHHCHHHHHHHH	39.57	25338131
458	N-linked_Glycosylation	KHIKKCNNDTSWTVL HHHHHCCCCCCHHEE	64.51	-
468	N-linked_Glycosylation	SWTVLASNVSNIITE CHHEEECHHHHHHHC	35.31	-
506	N-linked_Glycosylation	VRCLAKNNLSVVARE HHHHHHCCHHHHHHH	32.74	-
566	Phosphorylation	WRVIESISPDGHEYI EEEEEECCCCCCEEE	26.64	22817900
572	Phosphorylation	ISPDGHEYIYVDPMQ CCCCCCEEEEECCCC	7.59	20116462
574	Phosphorylation	PDGHEYIYVDPMQLP CCCCEEEEECCCCCC	9.63	22817900
582	Phosphorylation	VDPMQLPYDSRWEFP ECCCCCCCCCCCCCC	34.83	29514104
601	Phosphorylation	VLGRILGSGAFGKVV EEEEEECCCCCCCEE	24.41	29514104
606	Ubiquitination	LGSGAFGKVVEGTAY ECCCCCCCEEECCCC	36.33	-
611	Phosphorylation	FGKVVEGTAYGLSRS CCCEEECCCCCCCCC	11.82	29514104
613	Phosphorylation	KVVEGTAYGLSRSQP CEEECCCCCCCCCCC	20.59	22817900
616	Phosphorylation	EGTAYGLSRSQPVMK ECCCCCCCCCCCHHH	26.06	29514104
618	Phosphorylation	TAYGLSRSQPVMKVA CCCCCCCCCCHHHHH	35.15	29514104
638	Ubiquitination	PTARSSEKQALMSEL CCCCCHHHHHHHHHH	42.70	-
703	Ubiquitination	QHPEKPKKDLDIFGL HCCCCCCCCCCCCCC	72.54	22790023
716	Phosphorylation	GLNPADESTRSYVIL CCCCCCCCCCEEEEE	29.66	27717184
717	Phosphorylation	LNPADESTRSYVILS CCCCCCCCCEEEEEE	22.91	27717184
719	Phosphorylation	PADESTRSYVILSFE CCCCCCCEEEEEEEC	24.68	22817900
720	Phosphorylation	ADESTRSYVILSFEN CCCCCCEEEEEEECC	6.55	22817900
731	Phosphorylation	SFENNGDYMDMKQAD EECCCCCCCCHHHCC	9.09	22817900
739	Phosphorylation	MDMKQADTTQYVPML CCHHHCCCCCCCCCH	20.86	22499769
740	Phosphorylation	DMKQADTTQYVPMLE CHHHCCCCCCCCCHH	20.60	22499769
742	Phosphorylation	KQADTTQYVPMLERK HHCCCCCCCCCHHHH	12.39	20116462
752	Phosphorylation	MLERKEVSKYSDIQR CHHHHHHHCCHHHHH	27.28	22499769
753	Ubiquitination	LERKEVSKYSDIQRS HHHHHHHCCHHHHHH	54.68	-
754	Phosphorylation	ERKEVSKYSDIQRSL HHHHHHCCHHHHHHH	12.22	20116462
755	Phosphorylation	RKEVSKYSDIQRSLY HHHHHCCHHHHHHHC	31.79	22499769
760	Phosphorylation	KYSDIQRSLYDRPAS CCHHHHHHHCCCCCH	18.20	22499769
762	Phosphorylation	SDIQRSLYDRPASYK HHHHHHHCCCCCHHC	15.91	20116462
767	Phosphorylation	SLYDRPASYKKKSML HHCCCCCHHCCHHHC	39.92	22499769
768	Phosphorylation	LYDRPASYKKKSMLD HCCCCCHHCCHHHCC	29.00	20116462
772	Phosphorylation	PASYKKKSMLDSEVK CCHHCCHHHCCHHHH	33.19	29514104
776	Phosphorylation	KKKSMLDSEVKNLLS CCHHHCCHHHHHHCC	40.09	29514104
847	Phosphorylation	ARDIMHDSNYVSKGS HHHHHCCCCCCCCCC	18.51	22817900
849	Phosphorylation	DIMHDSNYVSKGSTF HHHCCCCCCCCCCCC	15.28	20116462
851	Phosphorylation	MHDSNYVSKGSTFLP HCCCCCCCCCCCCCC	22.42	29514104
852	Ubiquitination	HDSNYVSKGSTFLPV CCCCCCCCCCCCCCE	47.00	22790023
854	Phosphorylation	SNYVSKGSTFLPVKW CCCCCCCCCCCCEEE	21.52	29514104
855	Phosphorylation	NYVSKGSTFLPVKWM CCCCCCCCCCCEEEC	37.55	29514104
958	Phosphorylation	ENLLPGQYKKSYEKI HHHCCCCCHHCCEEE	26.71	29514104
962	Phosphorylation	PGQYKKSYEKIHLDF CCCCHHCCEEEEHHH	30.07	29514104
964	Ubiquitination	QYKKSYEKIHLDFLK CCHHCCEEEEHHHHH	27.48	22790023
971	Ubiquitination	KIHLDFLKSDHPAVA EEEHHHHHCCCCCEE	54.56	22790023
984	Phosphorylation	VARMRVDSDNAYIGV EEEEEECCCCCEEEE	29.88	29514104
988	Phosphorylation	RVDSDNAYIGVTYKN EECCCCCEEEEEEEC	12.40	22817900
993	Phosphorylation	NAYIGVTYKNEEDKL CCEEEEEEECHHHHC	14.92	29514104
1013	Phosphorylation	GLDEQRLSADSGYII CCCCCEECCCCCEEE	32.02	25619855
1016	Phosphorylation	EQRLSADSGYIIPLP CCEECCCCCEEEECC	32.96	25619855
1018	Phosphorylation	RLSADSGYIIPLPDI EECCCCCEEEECCCC	10.30	25619855
1036	Ubiquitination	PEEEDLGKRNRHSSQ CCHHHCCCCCCCCCC	54.52	-
1041	Phosphorylation	LGKRNRHSSQTSEES CCCCCCCCCCCCCHH	22.39	23684622
1042	Phosphorylation	GKRNRHSSQTSEESA CCCCCCCCCCCCHHH	31.21	23375375
1044	Phosphorylation	RNRHSSQTSEESAIE CCCCCCCCCCHHHHH	39.80	21183079
1045	Phosphorylation	NRHSSQTSEESAIET CCCCCCCCCHHHHHC	31.56	23684622
1048	Phosphorylation	SSQTSEESAIETGSS CCCCCCHHHHHCCCC	30.41	25168779
1052	Phosphorylation	SEESAIETGSSSSTF CCHHHHHCCCCCCCE	35.93	25168779
1054	Phosphorylation	ESAIETGSSSSTFIK HHHHHCCCCCCCEEE	34.17	23684622
1055	Phosphorylation	SAIETGSSSSTFIKR HHHHCCCCCCCEEEC	29.65	23684622
1056	Phosphorylation	AIETGSSSSTFIKRE HHHCCCCCCCEEECC	34.79	25338131
1057	Phosphorylation	IETGSSSSTFIKRED HHCCCCCCCEEECCC	29.32	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1018	Y	Phosphorylation	Kinase	PDGFRA	P26618	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	Cbl	P22682	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGFRA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGFRA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PGFRA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.