SP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SP7_HUMAN
• UniProt AC: Q8TDD2
• Protein Name: Transcription factor Sp7
• Gene Name: SP7
• Organism: Homo sapiens (Human).
• Sequence Length: 431
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator essential for osteoblast differentiation. [PubMed: 23457570 Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity; Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences.]
• Protein Sequence: MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQLEGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPGGSPEQSNLLEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASSLLEEEV -----CCCCHHHCHH	21.88	29759185
4	Phosphorylation	----MASSLLEEEVH ----CCCCHHHCHHH	27.69	29759185
30	Phosphorylation	ACSKFGGSSPLRDST HHHHHCCCCCCCCCC	29.21	-
31	Phosphorylation	CSKFGGSSPLRDSTT HHHHCCCCCCCCCCC	31.09	-
37	Phosphorylation	SSPLRDSTTLGKAGT CCCCCCCCCCCCCCC	30.26	-
38	Phosphorylation	SPLRDSTTLGKAGTK CCCCCCCCCCCCCCC	37.15	-
41	Ubiquitination	RDSTTLGKAGTKKPY CCCCCCCCCCCCCCC	46.91	-
41	Propionylation	RDSTTLGKAGTKKPY CCCCCCCCCCCCCCC	46.91	-
45	Propionylation	TLGKAGTKKPYSVGS CCCCCCCCCCCCCCC	51.32	-
49	Phosphorylation	AGTKKPYSVGSDLSA CCCCCCCCCCCCCCC	28.64	-
52	Phosphorylation	KKPYSVGSDLSASKT CCCCCCCCCCCCCCC	32.97	24719451
58	Ubiquitination	GSDLSASKTMGDAYP CCCCCCCCCCCCCCC	42.10	-
76	Phosphorylation	TSTNGLLSPAGSPPA CCCCCCCCCCCCCCC	20.11	-
80	Phosphorylation	GLLSPAGSPPAPTSG CCCCCCCCCCCCCCC	29.80	-
230	Ubiquitination	VLPQDVYKPKAVGNS CCCCCCCCCCCCCCC	39.63	-
237	Phosphorylation	KPKAVGNSGQLEGSG CCCCCCCCCCCCCCC	23.22	-
307	Acetylation	GCGKVYGKASHLKAH CCCCEEEEHHHHHHH	29.09	113429599
312	Acetylation	YGKASHLKAHLRWHT EEEHHHHHHHHHHCC	28.47	113429601
319	Phosphorylation	KAHLRWHTGERPFVC HHHHHHCCCCCCEEE	33.50	-
338	Phosphorylation	CGKRFTRSDELERHV ECCCCCCHHHHHHHH	32.17	25159151
361	Propionylation	FTCLLCSKRFTRSDH EEEEEECCCCCCHHH	51.00	-
364	Phosphorylation	LLCSKRFTRSDHLSK EEECCCCCCHHHHHH	33.04	-
366	Phosphorylation	CSKRFTRSDHLSKHQ ECCCCCCHHHHHHHH	26.73	-
370	Phosphorylation	FTRSDHLSKHQRTHG CCCHHHHHHHHHHCC	25.36	-
371	Propionylation	TRSDHLSKHQRTHGE CCHHHHHHHHHHCCC	50.55	-
396	Phosphorylation	KELGEGRSTGEEEAS CCCCCCCCCCHHHHH	52.17	-
397	Phosphorylation	ELGEGRSTGEEEASQ CCCCCCCCCHHHHHC	47.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SP7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHIP_HUMAN	STUB1	physical	25818514
CBL_HUMAN	CBL	physical	25744063
CBLB_HUMAN	CBLB	physical	25744063

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.