CD38_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD38_HUMAN
• UniProt AC: P28907
• Protein Name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• Gene Name: CD38
• Organism: Homo sapiens (Human).
• Sequence Length: 300
• Subcellular Localization: Membrane; Single-pass type II membrane protein.
• Protein Description: Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system..
• Protein Sequence: MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	FSPVSGDKPCCRLSR ECCCCCCCCCHHHHH	43.40	-
51	Phosphorylation	PRWRQQWSGPGTTKR HHHHHHCCCCCCCCC	30.67	28842319
100	N-linked_Glycosylation	FISKHPCNITEEDYQ HHCCCCCCCCHHHCH	48.98	19159218
158	Phosphorylation	GYLADDLTWCGEFNT HHHHCCCCEECCCCC	26.21	30576142
164	N-linked_Glycosylation	LTWCGEFNTSKINYQ CCEECCCCCCCCCCC	38.86	UniProtKB CARBOHYD
166	Phosphorylation	WCGEFNTSKINYQSC EECCCCCCCCCCCCC	32.42	30576142
181	Phosphorylation	PDWRKDCSNNPVSVF CCHHHHCCCCCCHHH	50.18	27732954
186	Phosphorylation	DCSNNPVSVFWKTVS HCCCCCCHHHHHHHH	16.92	27732954
209	N-linked_Glycosylation	DVVHVMLNGSRSKIF CEEEEECCCCCCCCC	28.44	19159218
219	N-linked_Glycosylation	RSKIFDKNSTFGSVE CCCCCCCCCCCCCEE	48.39	19159218
219	N-linked_Glycosylation	RSKIFDKNSTFGSVE CCCCCCCCCCCCCEE	48.39	19349973
220	O-linked_Glycosylation	SKIFDKNSTFGSVEV CCCCCCCCCCCCEEE	30.74	OGP
221	O-linked_Glycosylation	KIFDKNSTFGSVEVH CCCCCCCCCCCEEEE	41.21	OGP
229	N-linked_Glycosylation	FGSVEVHNLQPEKVQ CCCEEEECCCHHHEE	45.61	19349973
229	N-linked_Glycosylation	FGSVEVHNLQPEKVQ CCCEEEECCCHHHEE	45.61	19349973
258	Phosphorylation	RDLCQDPTIKELESI CHHHCCCHHHHHHHH	53.63	-
264	Phosphorylation	PTIKELESIISKRNI CHHHHHHHHHHHCCC	37.53	24719451
268	2-Hydroxyisobutyrylation	ELESIISKRNIQFSC HHHHHHHHCCCEEEC	38.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD38_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD38_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD38_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FCG3A_HUMAN	FCGR3A	physical	11895784
CD3E_HUMAN	CD3E	physical	14523017
CD3Z_HUMAN	CD247	physical	14523017
LCK_HUMAN	LCK	physical	14523017
ZAP70_HUMAN	ZAP70	physical	14523017

Drug and Disease Associations

• Kegg Disease
• H00005: Chronic lymphocytic leukemia (CLL)
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-219, AND MASSSPECTROMETRY.
PubMed: 19349973

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-100; ASN-209 AND ASN-219,AND MASS SPECTROMETRY.
PubMed: 19159218