FCG3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FCG3A_HUMAN
• UniProt AC: P08637
• Protein Name: Low affinity immunoglobulin gamma Fc region receptor III-A
• Gene Name: FCGR3A
• Organism: Homo sapiens (Human).
• Sequence Length: 254
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Secreted. Exists also as a soluble receptor.
• Protein Description: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis..
• Protein Sequence: MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKTNIRSSTRDWKDHKFKWRKDPQDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MWQLLLPTALLLLVS CHHHHHHHHHHHHHH	29.88	24043423
15	Phosphorylation	TALLLLVSAGMRTED HHHHHHHHCCCCCCC	21.05	24043423
56	N-linked_Glycosylation	GAYSPEDNSTQWFHN CCCCCCCCCCCEECC	45.34	UniProtKB CARBOHYD
63	N-linked_Glycosylation	NSTQWFHNESLISSQ CCCCEECCHHHCHHH	30.95	22023369
92	N-linked_Glycosylation	GEYRCQTNLSTLSDP CCEEEECCCCCCCCC	13.20	UniProtKB CARBOHYD
99	N-linked_Glycosylation	NLSTLSDPVQLEVHI CCCCCCCCEEEEEEH	16.63	22023369
163	Phosphorylation	DFYIPKATLKDSGSY CEEECCCEECCCCCE	40.23	-
167	Phosphorylation	PKATLKDSGSYFCRG CCCEECCCCCEECCE	28.22	-
169	Phosphorylation	ATLKDSGSYFCRGLF CEECCCCCEECCEEC	20.98	-
170	Phosphorylation	TLKDSGSYFCRGLFG EECCCCCEECCEECC	15.38	-
180	N-linked_Glycosylation	RGLFGSKNVSSETVN CEECCCCCCCCCEEE	40.37	22023369
187	N-linked_Glycosylation	NVSSETVNITITQGL CCCCCEEEEEEECCE	32.86	UniProtKB CARBOHYD
216	N-linked_Glycosylation	VSFCLVMVLLFAVDT HHHHHHHHHHHHHHC	3.07	22023369

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FCG3A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
180	N	Glycosylation	Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.	22023369

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FCG3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ZBT25_HUMAN	ZBTB25	physical	21988832
KSYK_HUMAN	SYK	physical	8189062
FCG3B_HUMAN	FCGR3B	physical	26186194
GLPK_HUMAN	GK	physical	26186194
BRE1B_HUMAN	RNF40	physical	26186194
FCGR1_HUMAN	FCGR1A	physical	25241761
RAB32_HUMAN	RAB32	physical	28514442
NCS1_HUMAN	NCS1	physical	28514442
GLPK_HUMAN	GK	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.