DOK3_MOUSE - dbPTM
DOK3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOK3_MOUSE
UniProt AC Q9QZK7
Protein Name Docking protein 3
Gene Name Dok3
Organism Mus musculus (Mouse).
Sequence Length 444
Subcellular Localization Cytoplasm. Cell membrane
Peripheral membrane protein
Cytoplasmic side.
Protein Description DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function..
Protein Sequence MESVEPPVKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWDVRDGGLGPAGDRSTGPSRRGERRVIRLADCVSVLPADGESCPRDTGAFLITTTERSHLLAAQHRQSWVDPICQLAFPGTGECSSGSGQAESPKRGFVPMEENSIYSSWQEVTEFPVIVQRTEATSRCQLKGPYLLVLGQDDIQLRETSKPQACFSWPYRFLRKYGSDKGVFSFEAGRRCDSGEGLFAFSSPRAPDICGVVAAAIARQRERLPELAMSPPCPLPRALSLPSLEPPGELREVAPGFELPTPRKLPLTDPGPQSLPLLLSPTQEGPASGLYASVCKQTSKHTGTAEHLYENVCMLEASPGLTNGGPEAQEGPPGGRSPLGSPIYHNTEDLSWPGSAQDSNLEAQYRRLLELELDEAGSAGRSGAQAGIKAKLVTLLTRERKKGPAPCDRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MESVEPPVKD
-----CCCCCCCCCC		30.4026643407
126PhosphorylationCQLAFPGTGECSSGS
HHEECCCCCCCCCCC		30.0024719451
130PhosphorylationFPGTGECSSGSGQAE
CCCCCCCCCCCCCCC		33.1725367039
131PhosphorylationPGTGECSSGSGQAES
CCCCCCCCCCCCCCC		48.9525159016
133PhosphorylationTGECSSGSGQAESPK
CCCCCCCCCCCCCCC		29.6725159016
138PhosphorylationSGSGQAESPKRGFVP
CCCCCCCCCCCCCCC		38.4425159016
244GlutathionylationSPRAPDICGVVAAAI
CCCCCCHHHHHHHHH		4.3924333276
264PhosphorylationRLPELAMSPPCPLPR
HCHHHHCCCCCCCCC		21.7826745281
274PhosphorylationCPLPRALSLPSLEPP
CCCCCCCCCCCCCCC		36.9326824392
277PhosphorylationPRALSLPSLEPPGEL
CCCCCCCCCCCCCCC		51.1325159016
295PhosphorylationAPGFELPTPRKLPLT
CCCCCCCCCCCCCCC		48.6430482847
302PhosphorylationTPRKLPLTDPGPQSL
CCCCCCCCCCCCCCC		37.9025159016
308PhosphorylationLTDPGPQSLPLLLSP
CCCCCCCCCCEEECC		34.7826824392
314PhosphorylationQSLPLLLSPTQEGPA
CCCCEEECCCCCCCC		26.3525159016
316PhosphorylationLPLLLSPTQEGPASG
CCEEECCCCCCCCCC		35.5625159016
322PhosphorylationPTQEGPASGLYASVC
CCCCCCCCCCCHHHH		32.2525159016
325PhosphorylationEGPASGLYASVCKQT
CCCCCCCCHHHHHHC		10.6025159016
327PhosphorylationPASGLYASVCKQTSK
CCCCCCHHHHHHCCC		17.9430635358
336PhosphorylationCKQTSKHTGTAEHLY
HHHCCCCCCCHHHHH		39.7125367039
338PhosphorylationQTSKHTGTAEHLYEN
HCCCCCCCHHHHHCC		29.9925367039
343PhosphorylationTGTAEHLYENVCMLE
CCCHHHHHCCEEEEE		13.8322817900
371PhosphorylationEGPPGGRSPLGSPIY
CCCCCCCCCCCCCCC		27.9621082442
375PhosphorylationGGRSPLGSPIYHNTE
CCCCCCCCCCCCCCC		18.7924224561
378PhosphorylationSPLGSPIYHNTEDLS
CCCCCCCCCCCCCCC		7.7522817900
381PhosphorylationGSPIYHNTEDLSWPG
CCCCCCCCCCCCCCC		19.9820531401
385PhosphorylationYHNTEDLSWPGSAQD
CCCCCCCCCCCCCCC		43.4729472430
389PhosphorylationEDLSWPGSAQDSNLE
CCCCCCCCCCCCCHH		20.7625367039
399PhosphorylationDSNLEAQYRRLLELE
CCCHHHHHHHHHHHH		12.5422817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOK3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOK3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOK3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CBL_MOUSECblphysical
21703542
INSR_MOUSEInsrphysical
10567556
ABL1_MOUSEAbl1physical
10567556
GRB2_MOUSEGrb2physical
26548852
TRAF6_MOUSETraf6physical
26548852
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOK3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274, AND MASSSPECTROMETRY.
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314 AND TYR-325, ANDMASS SPECTROMETRY.

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