ATS4_HUMAN - dbPTM
ATS4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATS4_HUMAN
UniProt AC O75173
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs 4
Gene Name ADAMTS4
Organism Homo sapiens (Human).
Sequence Length 837
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Protein Description Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site..
Protein Sequence MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
53PhosphorylationLPSARLASPLPREEE
CCCCHHCCCCCCHHH		31.4028188228
68N-linked_GlycosylationIVFPEKLNGSVLPGS
EECCHHCCCCCCCCC		52.33UniProtKB CARBOHYD
185PhosphorylationAHILRRKSPASGQGP
CEEEECCCCCCCCCC		24.7268729689
204PhosphorylationKAPLGSPSPRPRRAK
ECCCCCCCCCCHHHH		34.9317081983
215PhosphorylationRRAKRFASLSRFVET
HHHHHHHHHHHHHHH		24.9424719451
217PhosphorylationAKRFASLSRFVETLV
HHHHHHHHHHHHHEE		22.6027174698
241PhosphorylationHGAGLKRYLLTVMAA
CCCCHHHHHHHHHHH		12.416972483
244PhosphorylationGLKRYLLTVMAAAAK
CHHHHHHHHHHHHHH		12.9746159367
257PhosphorylationAKAFKHPSIRNPVSL
HHHCCCCCCCCCHHH		33.6224719451
408PhosphorylationEEPWSPCSARFITDF
CCCCCCCCHHHHHHH		26.3422210691
413PhosphorylationPCSARFITDFLDNGY
CCCHHHHHHHHHCCC		20.2722210691
689PhosphorylationGSGCSKQSGSFRKFR
CCCCCCCCCCCCCEE		39.8926437602
691PhosphorylationGCSKQSGSFRKFRYG
CCCCCCCCCCCEECC		27.4226437602
697PhosphorylationGSFRKFRYGYNNVVT
CCCCCEECCCCCEEE		27.3924043423
699PhosphorylationFRKFRYGYNNVVTIP
CCCEECCCCCEEEEC		8.4724043423
704PhosphorylationYGYNNVVTIPAGATH
CCCCCEEEECCCCCE		19.5724043423
710PhosphorylationVTIPAGATHILVRQQ
EEECCCCCEEEEEEC		14.4524043423
761PhosphorylationPGAVSLRYSGATAAS
CCCEEEEECCCCCCC		19.4222210691
762PhosphorylationGAVSLRYSGATAASE
CCEEEEECCCCCCCH		18.6024043423
765PhosphorylationSLRYSGATAASETLS
EEEECCCCCCCHHHC		26.7024043423
768PhosphorylationYSGATAASETLSGHG
ECCCCCCCHHHCCCC		28.7522210691
770PhosphorylationGATAASETLSGHGPL
CCCCCCHHHCCCCCC		24.5924043423
772PhosphorylationTAASETLSGHGPLAQ
CCCCHHHCCCCCCCC		35.8424043423
782PhosphorylationGPLAQPLTLQVLVAG
CCCCCCEEEEEEECC		23.1022210691
813O-linked_GlycosylationTPSTPRPTPQDWLHR
CCCCCCCCCHHHHHH		34.56OGP
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATS4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATS4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATS4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZBT16_HUMANZBTB16physical
21988832
YTDC1_HUMANYTHDC1physical
21988832
TBB1_HUMANTUBB1physical
28514442
XIAP_HUMANXIAPphysical
28514442
BIRC2_HUMANBIRC2physical
28514442
K0232_HUMANKIAA0232physical
28514442
DICER_HUMANDICER1physical
28514442
LOXL2_HUMANLOXL2physical
28514442
DPH6_HUMANDPH6physical
28514442
TBA4A_HUMANTUBA4Aphysical
28514442
RA51B_HUMANRAD51Bphysical
28514442
AT2B2_HUMANATP2B2physical
28514442
TBB3_HUMANTUBB3physical
28514442
ATS2_HUMANADAMTS2physical
28514442
ITPA_HUMANITPAphysical
28514442
FRAS1_HUMANFRAS1physical
28514442
TBA1A_HUMANTUBA1Aphysical
28514442
TRAF2_HUMANTRAF2physical
28514442
MANBA_HUMANMANBAphysical
28514442
MKS1_HUMANMKS1physical
28514442
TRBP2_HUMANTARBP2physical
28514442
RA51C_HUMANRAD51Cphysical
28514442
BIRC6_HUMANBIRC6physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATS4_HUMAN

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Related Literatures of Post-Translational Modification

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