ZFAN6_HUMAN - dbPTM
ZFAN6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZFAN6_HUMAN
UniProt AC Q6FIF0
Protein Name AN1-type zinc finger protein 6
Gene Name ZFAND6
Organism Homo sapiens (Human).
Sequence Length 208
Subcellular Localization Cytoplasm.
Protein Description Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity)..
Protein Sequence MAQETNHSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPATSVSSLSESLPVQCTDGSVPEAQSALDSTSSSMQPSPVSNQSLLSESVASSQLDSTSVDKAVPETEDVQASVSDTAQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MAQETNHSQVPM
---CCCCCCCCCCCE		26.5924043423
8PhosphorylationMAQETNHSQVPMLCS
CCCCCCCCCCCEEEC		34.6424043423
15PhosphorylationSQVPMLCSTGCGFYG
CCCCEEECCCCCCCC		24.7124043423
16PhosphorylationQVPMLCSTGCGFYGN
CCCEEECCCCCCCCC		35.1824043423
21PhosphorylationCSTGCGFYGNPRTNG
ECCCCCCCCCCCCCC		10.9824043423
26PhosphorylationGFYGNPRTNGMCSVC
CCCCCCCCCCCCCHH		37.0624043423
31PhosphorylationPRTNGMCSVCYKEHL
CCCCCCCCHHHHHHH		13.3124043423
34PhosphorylationNGMCSVCYKEHLQRQ
CCCCCHHHHHHHHHH		19.7724043423
35UbiquitinationGMCSVCYKEHLQRQN
CCCCHHHHHHHHHHC		33.27-
43PhosphorylationEHLQRQNSSNGRISP
HHHHHHCCCCCCCCC		19.4926074081
44PhosphorylationHLQRQNSSNGRISPP
HHHHHCCCCCCCCCC		51.3426074081
49PhosphorylationNSSNGRISPPATSVS
CCCCCCCCCCCCCHH		24.3826074081
53PhosphorylationGRISPPATSVSSLSE
CCCCCCCCCHHHCCC		35.1226074081
54PhosphorylationRISPPATSVSSLSES
CCCCCCCCHHHCCCC		23.3126074081
56PhosphorylationSPPATSVSSLSESLP
CCCCCCHHHCCCCCC		25.9026074081
57PhosphorylationPPATSVSSLSESLPV
CCCCCHHHCCCCCCC		33.4926074081
59PhosphorylationATSVSSLSESLPVQC
CCCHHHCCCCCCCCC		27.3826074081
88PhosphorylationTSSSMQPSPVSNQSL
CCCCCCCCCCCCHHH		22.5026074081
91PhosphorylationSMQPSPVSNQSLLSE
CCCCCCCCCHHHHCH		32.3226074081
110UbiquitinationSQLDSTSVDKAVPET
HCCCCCCCCCCCCCC		9.9121890473
114UbiquitinationSTSVDKAVPETEDVQ
CCCCCCCCCCCHHCC		5.6122817900
117PhosphorylationVDKAVPETEDVQASV
CCCCCCCCHHCCCHH		31.2625159151
123PhosphorylationETEDVQASVSDTAQQ
CCHHCCCHHCCCCCC		12.6928450419
125 (in isoform 2)Ubiquitination-27.0921890473
125UbiquitinationEDVQASVSDTAQQPS
HHCCCHHCCCCCCCC		27.0921890473
125PhosphorylationEDVQASVSDTAQQPS
HHCCCHHCCCCCCCC		27.0928450419
127PhosphorylationVQASVSDTAQQPSEE
CCCHHCCCCCCCCHH		20.8930576142
128UbiquitinationQASVSDTAQQPSEEQ
CCHHCCCCCCCCHHH		15.8224816145
129UbiquitinationASVSDTAQQPSEEQS
CHHCCCCCCCCHHHH		58.7822817900
132PhosphorylationSDTAQQPSEEQSKSL
CCCCCCCCHHHHHHC		49.8023401153
136PhosphorylationQQPSEEQSKSLEKPK
CCCCHHHHHHCCCHH		27.7329116813
137 (in isoform 1)Ubiquitination-59.7721890473
137UbiquitinationQPSEEQSKSLEKPKQ
CCCHHHHHHCCCHHH		59.7721890473
138PhosphorylationPSEEQSKSLEKPKQK
CCHHHHHHCCCHHHH		47.1929496963
141UbiquitinationEQSKSLEKPKQKKNR
HHHHHCCCHHHHCCC		63.9122817900
143AcetylationSKSLEKPKQKKNRCF
HHHCCCHHHHCCCEE		82.7425953088
143UbiquitinationSKSLEKPKQKKNRCF
HHHCCCHHHHCCCEE		82.7424816145
148UbiquitinationKPKQKKNRCFMCRKK
CHHHHCCCEEECCCC		24.7527667366
154UbiquitinationNRCFMCRKKVGLTGF
CCEEECCCCCCCCCE		47.0533845483
155UbiquitinationRCFMCRKKVGLTGFE
CEEECCCCCCCCCEE		23.3724816145
157UbiquitinationFMCRKKVGLTGFECR
EECCCCCCCCCEEEE		26.8032015554
159PhosphorylationCRKKVGLTGFECRCG
CCCCCCCCCEEEECC		33.6228555341
159UbiquitinationCRKKVGLTGFECRCG
CCCCCCCCCEEEECC		33.6227667366
165UbiquitinationLTGFECRCGNVYCGV
CCCEEEECCCEEEEE		7.6133845483
166UbiquitinationTGFECRCGNVYCGVH
CCEEEECCCEEEEEE		13.7932015554
168UbiquitinationFECRCGNVYCGVHRY
EEEECCCEEEEEEEC		2.2532015554
169UbiquitinationECRCGNVYCGVHRYS
EEECCCEEEEEEECC		6.3624816145
174UbiquitinationNVYCGVHRYSDVHNC
CEEEEEEECCCCCCC		30.1927667366
176PhosphorylationYCGVHRYSDVHNCSY
EEEEEECCCCCCCCC		32.8725159151
177UbiquitinationCGVHRYSDVHNCSYN
EEEEECCCCCCCCCE		36.4432015554
180UbiquitinationHRYSDVHNCSYNYKA
EECCCCCCCCCEECH		19.1133845483
182PhosphorylationYSDVHNCSYNYKADA
CCCCCCCCCEECHHH		23.0225159151
183UbiquitinationSDVHNCSYNYKADAA
CCCCCCCCEECHHHH		25.3932015554
185PhosphorylationVHNCSYNYKADAAEK
CCCCCCEECHHHHHH		10.18-
186UbiquitinationHNCSYNYKADAAEKI
CCCCCEECHHHHHHH		35.8327667366
192UbiquitinationYKADAAEKIRKENPV
ECHHHHHHHHHHCCE		42.9832015554
195UbiquitinationDAAEKIRKENPVVVG
HHHHHHHHHCCEEEE		66.3733845483
204AcetylationNPVVVGEKIQKI---
CCEEEEHHHCCC---		44.5023954790
204UbiquitinationNPVVVGEKIQKI---
CCEEEEHHHCCC---		44.5027667366
207AcetylationVVGEKIQKI------
EEEHHHCCC------		54.5825953088
207UbiquitinationVVGEKIQKI------
EEEHHHCCC------		54.5824816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZFAN6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZFAN6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZFAN6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRAF2_HUMANTRAF2physical
21810480
CDV3_HUMANCDV3physical
26344197
CIRBP_HUMANCIRBPphysical
26344197
GSHB_HUMANGSSphysical
26344197
ROA3_HUMANHNRNPA3physical
26344197
NONO_HUMANNONOphysical
26344197
TXLNG_HUMANTXLNGphysical
26344197
TRAF2_HUMANTRAF2physical
28514442
BIRC2_HUMANBIRC2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZFAN6_HUMAN

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Related Literatures of Post-Translational Modification

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