FDXA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FDXA1_HUMAN
• UniProt AC: Q9BRP7
• Protein Name: Ferredoxin-fold anticodon-binding domain-containing protein 1
• Gene Name: FDXACB1
• Organism: Homo sapiens (Human).
• Sequence Length: 624
• Protein Sequence: MAPRRLLLVGEGNFSFAAALSETLDQSTQLTATCLQRPAELARDPLAWENLQCLRERGIDVRFGVDCTQLADVFELHEREFDQIYFIFPHCGRKAGVAKNRELLAKFFQSCADVLAEEGEVHVALCRGQGGTPADKPQREWHNSWQVVAMAALGGLILSDVYPFSCKAVAGYKCTGYRSQDKSFHVEGALNHIFTRSLPFEGSQPRIFRIKLGNQWFSFPEPEALVGKLNRGFLEAPSCHPIKTINEKLIAELGKVFPLKRLKCSYPLLPQEGTSVLPFWNCDFLSAAFWISLHEDNSNSESLTGGTSQDVEDFLVSFSELSLLKNPGRDGKEEACEGTCGQAKICLRPSLLVHVQDVIEVPDFLSGSLHILSGPVFQKCHILPFTMPAFHETLFILGVNQNLKDGCLQSLLDHLKGILDSLLTQTLPESSKLSSLVKFVLQSNGKDYMIRVKTHNFSPDCTEDLIIGSVITSATSVIHKDQCFVFVSMNLDLLAMLVWCISDWRMLWTFDNRFLKNFVPGKIEPFKSHSLYPPCYVHDVSFWIDQKKGFDELEFHTVARAVSQDTIISIQFLSRFQHPKTQQVSLCYRLTYQTCDKALTQQQVASMQSQFRKEIQQHLYVIPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Acetylation	GRKAGVAKNRELLAK CCCCCHHHCHHHHHH	54.88	24848129
173	Ubiquitination	CKAVAGYKCTGYRSQ CCEEECCCCCCEECC	25.14	29967540
243	Ubiquitination	APSCHPIKTINEKLI CCCCCCCCCCCHHHH	48.04	-
248	Ubiquitination	PIKTINEKLIAELGK CCCCCCHHHHHHHCC	40.48	29967540
322	Phosphorylation	LVSFSELSLLKNPGR HHCHHHHHCCCCCCC	27.83	24719451
373	Phosphorylation	SGSLHILSGPVFQKC CCCEEEECCCHHHCC	40.21	24719451
410	Phosphorylation	LKDGCLQSLLDHLKG CCCCHHHHHHHHHHH	20.25	25159151
421	Phosphorylation	HLKGILDSLLTQTLP HHHHHHHHHHHHCCC	23.10	20230923
424	Phosphorylation	GILDSLLTQTLPESS HHHHHHHHHCCCCHH	25.46	20230923
426	Phosphorylation	LDSLLTQTLPESSKL HHHHHHHCCCCHHCH	38.76	26074081
430	Phosphorylation	LTQTLPESSKLSSLV HHHCCCCHHCHHHHH	30.73	26074081
431	Phosphorylation	TQTLPESSKLSSLVK HHCCCCHHCHHHHHH	35.63	20230923
434	Phosphorylation	LPESSKLSSLVKFVL CCCHHCHHHHHHHHH	25.93	26074081
435	Phosphorylation	PESSKLSSLVKFVLQ CCHHCHHHHHHHHHH	47.84	26074081
464	Ubiquitination	FSPDCTEDLIIGSVI CCCCCCCCCCHHCHH	25.64	-
522	Ubiquitination	LKNFVPGKIEPFKSH HHHCCCCCCCCCCCC	37.51	29967540
581	Phosphorylation	SRFQHPKTQQVSLCY HHCCCCCCCCEEEEH	28.78	-
585	Phosphorylation	HPKTQQVSLCYRLTY CCCCCCEEEEHHHHH	14.37	-
588	Phosphorylation	TQQVSLCYRLTYQTC CCCEEEEHHHHHHHH	17.60	21214269
613	Ubiquitination	SMQSQFRKEIQQHLY HHHHHHHHHHHHHHE	61.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FDXA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FDXA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FDXA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RMXL2_HUMAN	RBMXL2	physical	22939629
HERC4_HUMAN	HERC4	physical	28514442
RMXL1_HUMAN	RBMXL1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.