HENMT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HENMT_HUMAN
• UniProt AC: Q5T8I9
• Protein Name: Small RNA 2'-O-methyltransferase
• Gene Name: HENMT1
• Organism: Homo sapiens (Human).
• Sequence Length: 393
• Subcellular Localization: Cytoplasm . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
• Protein Description: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis..
• Protein Sequence: MEENNLQCSSVVDGNFEEVPRETAIQFKPPLYRQRYQFVKNLVDQHEPKKVADLGCGDTSLLRLLKVNPCIELLVGVDINEDKLRWRGDSLAPFLGDFLKPRDLNLTITLYHGSVVERDSRLLGFDLITCIELIEHLDSGDLARFPEVVFGYLSPSMIVISTPNSEFNPLFPSVTLRDSDHKFEWTRMEFQTWALYVANRYDYSVEFTGVGEPPAGAENVGYCTQIGIFRKNGGKATESCLSEQHDQHVYKAVFTTSYPSLQQERFFKLVLVNEVSQQVESLRVSHLPRRKEQAGERGDKPKDIGGSKAPVPCFGPVFTEVEKAKIENSPTPFCVGDKFFVPLQRLLAYPKLNRLCANEEMMRSVIADSIPLSSDGSAVVADLRNYFDEQFEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Ubiquitination	RETAIQFKPPLYRQR HHHCCCCCCCHHHHH	29.38	29967540
40	Ubiquitination	RQRYQFVKNLVDQHE HHHHHHHHHHHHHCC	45.94	21963094
48	Ubiquitination	NLVDQHEPKKVADLG HHHHHCCCCCHHHCC	39.38	21963094
49	Ubiquitination	LVDQHEPKKVADLGC HHHHCCCCCHHHCCC	57.82	29967540
50	Ubiquitination	VDQHEPKKVADLGCG HHHCCCCCHHHCCCC	54.06	22505724
58	Ubiquitination	VADLGCGDTSLLRLL HHHCCCCCHHHHHHH	36.88	22505724
60	Phosphorylation	DLGCGDTSLLRLLKV HCCCCCHHHHHHHCC	30.10	24719451
79	Ubiquitination	ELLVGVDINEDKLRW EEEEECCCCCCCCCC	5.89	22505724
90	Phosphorylation	KLRWRGDSLAPFLGD CCCCCCCCCHHHHHH	29.29	-
95	Ubiquitination	GDSLAPFLGDFLKPR CCCCHHHHHHHCCCC	6.65	21963094
100	Ubiquitination	PFLGDFLKPRDLNLT HHHHHHCCCCCCCEE	37.69	21963094
108	Ubiquitination	PRDLNLTITLYHGSV CCCCCEEEEEEECCC	2.55	21963094
152	Ubiquitination	FPEVVFGYLSPSMIV CCHHHHEECCCCEEE	7.79	21963094
167	Ubiquitination	ISTPNSEFNPLFPSV EECCCCCCCCCCCCE	13.16	21963094
175	Phosphorylation	NPLFPSVTLRDSDHK CCCCCCEEEECCCCC	22.03	24719451
182	Ubiquitination	TLRDSDHKFEWTRME EEECCCCCEEEEEHH	50.39	21963094
235	Ubiquitination	IFRKNGGKATESCLS EEECCCCCCCHHHCH	54.24	22505724
243	Ubiquitination	ATESCLSEQHDQHVY CCHHHCHHHHHHHHH	38.70	22505724
251	Ubiquitination	QHDQHVYKAVFTTSY HHHHHHHHHHEECCC	36.66	21963094
259	Ubiquitination	AVFTTSYPSLQQERF HHEECCCCHHHHHHH	28.47	21963094
300	Ubiquitination	QAGERGDKPKDIGGS HCCCCCCCCCCCCCC	57.71	-
308	Ubiquitination	PKDIGGSKAPVPCFG CCCCCCCCCCCCCCC	61.04	21963094
316	Ubiquitination	APVPCFGPVFTEVEK CCCCCCCCCCCCHHH	9.59	21963094
323	Ubiquitination	PVFTEVEKAKIENSP CCCCCHHHHHHCCCC	61.22	21963094
325	Ubiquitination	FTEVEKAKIENSPTP CCCHHHHHHCCCCCC	62.71	29967540
329	Phosphorylation	EKAKIENSPTPFCVG HHHHHCCCCCCCCCC	19.84	21815630
331	Ubiquitination	AKIENSPTPFCVGDK HHHCCCCCCCCCCCC	28.90	21963094
338	Ubiquitination	TPFCVGDKFFVPLQR CCCCCCCCCHHCHHH	34.47	21963094
346	Ubiquitination	FFVPLQRLLAYPKLN CHHCHHHHHHHHHHH	1.75	21963094
351	Ubiquitination	QRLLAYPKLNRLCAN HHHHHHHHHHHHHCC	45.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HENMT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HENMT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HENMT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PECR_HUMAN	PECR	physical	28514442
MTD2L_HUMAN	MTHFD2L	physical	28514442
SNX6_HUMAN	SNX6	physical	28514442
KIF3A_HUMAN	KIF3A	physical	28514442
SNX2_HUMAN	SNX2	physical	28514442
MTMR5_HUMAN	SBF1	physical	28514442
TXLNA_HUMAN	TXLNA	physical	28514442
RA51C_HUMAN	RAD51C	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.