dbPTM

CU059_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CU059_HUMAN
UniProt AC	P57076
Protein Name	UPF0769 protein C21orf59
Gene Name	C21orf59
Organism	Homo sapiens (Human).
Sequence Length	290
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization.
Protein Description	Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. [PubMed: 24094744 Seems to be important for initiation rather than maintenance of cilium motility (By similarity Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity May suppress canonical Wnt signaling activity (By similarity]
Protein Sequence	MVLLHVKRGDESQFLLQAPGSTELEELTVQVARVYNGRLKVQRLCSEMEELAEHGIFLPPNMQGLTDDQIEELKLKDEWGEKCVPSGGAVFKKDDIGRRNGQAPNEKMKQVLKKTIEEAKAIISKKQVEAGVCVTMEMVKDALDQLRGAVMIVYPMGLPPYDPIRMEFENKEDLSGTQAGLNVIKEAEAQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQRGQGAPAREPIISSEEQKQLMLYYHRRQEELKRLEENDDDAYLNSPWADNTALKRHFHGVKDIKWRPR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
219	Acetylation	EKTKIIAKIQQRGQG CCHHHHHHHHHCCCC	30.55	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CU059_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CU059_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CU059_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
PEX7_HUMAN	PEX7	physical	26186194
PLAK_HUMAN	JUP	physical	26186194
HUTH_HUMAN	HAL	physical	26186194
CALL5_HUMAN	CALML5	physical	26186194
TGM1_HUMAN	TGM1	physical	26186194
APRV1_HUMAN	ASPRV1	physical	26186194
TGM3_HUMAN	TGM3	physical	26186194
RNAS7_HUMAN	RNASE7	physical	26186194
FILA_HUMAN	FLG	physical	26186194
SAP3_HUMAN	GM2A	physical	26186194
POF1B_HUMAN	POF1B	physical	26186194
CDSN_HUMAN	CDSN	physical	26186194
SPA12_HUMAN	SERPINA12	physical	26186194
SPB8_HUMAN	SERPINB8	physical	26186194
CBPA4_HUMAN	CPA4	physical	26186194
PAI2_HUMAN	SERPINB2	physical	26186194
FBX50_HUMAN	NCCRP1	physical	26186194
ECM1_HUMAN	ECM1	physical	26186194
GLRX1_HUMAN	GLRX	physical	26186194
SPB7_HUMAN	SERPINB7	physical	26186194
KLK5_HUMAN	KLK5	physical	26186194
HNRH1_HUMAN	HNRNPH1	physical	26344197
PLXB1_HUMAN	PLXNB1	physical	26496610
STK3_HUMAN	STK3	physical	26496610
ARK72_HUMAN	AKR7A2	physical	26496610
SCC4_HUMAN	MAU2	physical	26496610
PGAP2_HUMAN	PGAP2	physical	26496610
ILKAP_HUMAN	ILKAP	physical	26496610
CU059_HUMAN	C21orf59	physical	26472760
CTNA1_HUMAN	CTNNA1	physical	26472760
CTNB1_HUMAN	CTNNB1	physical	26472760
GLRX1_HUMAN	GLRX	physical	28514442
PEX7_HUMAN	PEX7	physical	28514442
SPB8_HUMAN	SERPINB8	physical	28514442
SPB7_HUMAN	SERPINB7	physical	28514442
PAI2_HUMAN	SERPINB2	physical	28514442
HPBP1_HUMAN	HSPBP1	physical	28514442
CDSN_HUMAN	CDSN	physical	28514442
ECM1_HUMAN	ECM1	physical	28514442
CBPA4_HUMAN	CPA4	physical	28514442
HUTH_HUMAN	HAL	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
RNAS7_HUMAN	RNASE7	physical	28514442
SPA12_HUMAN	SERPINA12	physical	28514442
FBX50_HUMAN	NCCRP1	physical	28514442
KLK5_HUMAN	KLK5	physical	28514442
FILA_HUMAN	FLG	physical	28514442
POF1B_HUMAN	POF1B	physical	28514442
TGM1_HUMAN	TGM1	physical	28514442
ARGI1_HUMAN	ARG1	physical	28514442
DSG1_HUMAN	DSG1	physical	28514442
SAP3_HUMAN	GM2A	physical	28514442
CALL5_HUMAN	CALML5	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615500	Ciliary dyskinesia, primary, 26 (CILD26)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CU059_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-283, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-264, AND MASSSPECTROMETRY.	15592455 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-210, AND MASSSPECTROMETRY.	17370265 [Abstract]