DJC28_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DJC28_HUMAN
• UniProt AC: Q9NX36
• Protein Name: DnaJ homolog subfamily C member 28
• Gene Name: DNAJC28
• Organism: Homo sapiens (Human).
• Sequence Length: 388
• Protein Description: May have a role in protein folding or as a chaperone..
• Protein Sequence: MNTMYVMMAQILRSHLIKATVIPNRVKMLPYFGIIRNRMMSTHKSKKKIREYYRLLNVEEGCSADEVRESFHKLAKQYHPDSGSNTADSATFIRIEKAYRKVLSHVIEQTNASQSKGEEEEDVEKFKYKTPQHRHYLSFEGIGFGTPTQREKHYRQFRADRAAEQVMEYQKQKLQSQYFPDSVIVKNIRQSKQQKITQAIERLVEDLIQESMAKGDFDNLSGKGKPLKKFSDCSYIDPMTHNLNRILIDNGYQPEWILKQKEISDTIEQLREAILVSRKKLGNPMTPTEKKQWNHVCEQFQENIRKLNKRINDFNLIVPILTRQKVHFDAQKEIVRAQKIYETLIKTKEVTDRNPNNLDQGEGEKTPEIKKGFLNWMNLWKFIKIRSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MNTMYVMMAQ -----CCHHHHHHHH	14.47	24043423
5	Phosphorylation	---MNTMYVMMAQIL ---CCHHHHHHHHHH	5.33	24043423
14	Phosphorylation	MMAQILRSHLIKATV HHHHHHHHHHCHHEE	21.14	24043423
20	Phosphorylation	RSHLIKATVIPNRVK HHHHCHHEECCCCCC	17.61	24043423
31	Phosphorylation	NRVKMLPYFGIIRNR CCCCCHHHHHHHHHH	15.52	22817900
76	Acetylation	ESFHKLAKQYHPDSG HHHHHHHHHHCCCCC	62.92	19821069
84	Phosphorylation	QYHPDSGSNTADSAT HHCCCCCCCCCCCHH	34.65	-
97	Acetylation	ATFIRIEKAYRKVLS HHHHHHHHHHHHHHH	48.63	19821077
128	Phosphorylation	EDVEKFKYKTPQHRH HHHHHHCCCCCCCCC	24.19	24719451
130	Phosphorylation	VEKFKYKTPQHRHYL HHHHCCCCCCCCCEE	25.70	24719451
169	Phosphorylation	AAEQVMEYQKQKLQS HHHHHHHHHHHHHHH	11.69	27642862
223	Ubiquitination	DFDNLSGKGKPLKKF CHHHCCCCCCCCCCC	61.46	22817900
225	Ubiquitination	DNLSGKGKPLKKFSD HHCCCCCCCCCCCCC	51.14	22817900
228	Ubiquitination	SGKGKPLKKFSDCSY CCCCCCCCCCCCCCC	61.37	22817900
229	Ubiquitination	GKGKPLKKFSDCSYI CCCCCCCCCCCCCCC	58.76	22817900
252	Phosphorylation	RILIDNGYQPEWILK HHEECCCCCCHHHHC	27.44	27174698
286	Phosphorylation	KKLGNPMTPTEKKQW HHHCCCCCCCHHHHH	28.46	23403867
288	Phosphorylation	LGNPMTPTEKKQWNH HCCCCCCCHHHHHHH	51.80	26657352
341	Phosphorylation	IVRAQKIYETLIKTK HHHHHHHHHHHHHHH	15.19	20049867
347	Phosphorylation	IYETLIKTKEVTDRN HHHHHHHHHCCCCCC	25.99	17693683

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DJC28_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DJC28_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DJC28_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRC46_HUMAN	LRRC46	physical	26186194
ATPB_HUMAN	ATP5B	physical	28514442
LRC46_HUMAN	LRRC46	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-347, AND MASSSPECTROMETRY.
PubMed: 17693683