NRX2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRX2A_HUMAN
• UniProt AC: Q9P2S2
• Protein Name: Neurexin-2
• Gene Name: NRXN2
• Organism: Homo sapiens (Human).
• Sequence Length: 1712
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling..
• Protein Sequence: MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	ARWAGAASSGELSFS HHCCCCCCCCCCEEE	38.04	25022875
54	Phosphorylation	AASSGELSFSLRTNA CCCCCCCEEEECCCC	14.42	24719451
56	Phosphorylation	SSGELSFSLRTNATR CCCCCEEEECCCCCE	17.36	24719451
60	N-linked_Glycosylation	LSFSLRTNATRALLL CEEEECCCCCEEEEE	32.64	UniProtKB CARBOHYD
162	Phosphorylation	IPPDVRLSALTLSTV CCCCCEEEEEEEECC	15.63	23403867
165	Phosphorylation	DVRLSALTLSTVKYE CCEEEEEEEECCCCC	20.55	23403867
330	Phosphorylation	RNGLMLHTGKSADYV HCCEEEECCCCCCEE	42.20	20860994
338	N-linked_Glycosylation	GKSADYVNLSLKSGA CCCCCEEEEEECCCC	20.06	UniProtKB CARBOHYD
340	Phosphorylation	SADYVNLSLKSGAVW CCCEEEEEECCCCEE	28.66	24719451
518	Phosphorylation	AKRTGSISLDFRTTE CCCCCEEEEEEECCC	24.47	24719451
544	Phosphorylation	RAGGGAGSHSSAQRA CCCCCCCCCCHHHHH	21.47	-
546	Phosphorylation	GGGAGSHSSAQRADY CCCCCCCCHHHHHCH	29.12	-
547	Phosphorylation	GGAGSHSSAQRADYF CCCCCCCHHHHHCHH	24.01	-
571	Phosphorylation	YLLLDMGSGGIKLRA EEEEECCCCCEEEEE	27.49	-
580	Phosphorylation	GIKLRASSRKVNDGE CEEEEEECCCCCCCC	34.83	-
601	Phosphorylation	QRDGRKGSISVNSRS ECCCCEEEEEECCCC	18.09	22210691
603	Phosphorylation	DGRKGSISVNSRSTP CCCEEEEEECCCCCC	19.55	22210691
606	Phosphorylation	KGSISVNSRSTPFLA EEEEEECCCCCCEEC	26.00	22210691
757	Phosphorylation	HTEAEDVSLRFMSQR CCCHHHCHHHHHHHH	26.58	-
762	Phosphorylation	DVSLRFMSQRAYGLM HCHHHHHHHHHHCEE	17.50	-
766	Phosphorylation	RFMSQRAYGLMMATT HHHHHHHHCEEEECC	17.00	-
772	Phosphorylation	AYGLMMATTSRESAD HHCEEEECCCCCCCC	13.86	29759185
773	Phosphorylation	YGLMMATTSRESADT HCEEEECCCCCCCCE	19.09	29759185
774	Phosphorylation	GLMMATTSRESADTL CEEEECCCCCCCCEE	29.69	-
777	Phosphorylation	MATTSRESADTLRLE EECCCCCCCCEEEEE	30.27	29759185
780	Phosphorylation	TSRESADTLRLELDG CCCCCCCEEEEEECC	17.31	-
793	Phosphorylation	DGGQMKLTVNLDCLR CCCEEEEEEEEEEEE	11.22	23403867
841	N-linked_Glycosylation	SLQLSVDNVTVEGQM CEEEEEEEEEEECEE	29.24	UniProtKB CARBOHYD
843	Phosphorylation	QLSVDNVTVEGQMAG EEEEEEEEEECEECC	21.06	22210691
866	Phosphorylation	NIETGIMTERRFISV CCCCCEECCCEEEEE	25.15	22210691
992	Phosphorylation	PSLMKGNSDKPVNDN CCCCCCCCCCCCCCC	56.53	-
1058	Phosphorylation	NLPKLVASRDGFQGC CCCHHHHCCCCCCCE	24.35	-
1236	N-linked_Glycosylation	RFTRSGGNATLQVDS EEEECCCCEEEEEEC	33.02	UniProtKB CARBOHYD
1269	Phosphorylation	IARQRIPYRLGRVVD HHHHHCCHHHHHHHH	18.99	-
1364	Phosphorylation	LLADMATTIMETTTT HHHHHHHHHHHHCCC	14.59	-
1368	Phosphorylation	MATTIMETTTTMATT HHHHHHHHCCCCCCC	16.44	-
1382	Phosphorylation	TTTRRGRSPTLRDST CCCCCCCCCCCCCCC	25.68	22167270
1384	Phosphorylation	TRRGRSPTLRDSTTQ CCCCCCCCCCCCCCC	35.35	22167270
1528	Phosphorylation	TDRTTLLSPRKPAPR CCCCCCCCCCCCCCC	26.27	24719451
1667	Phosphorylation	YRNRDEGSYQVDQSR HCCCCCCCCEECCCC	15.45	29978859
1668	Phosphorylation	RNRDEGSYQVDQSRN CCCCCCCCEECCCCC	24.34	29978859
1673	Phosphorylation	GSYQVDQSRNYISNS CCCEECCCCCCCCCC	20.30	29978859
1676	Phosphorylation	QVDQSRNYISNSAQS EECCCCCCCCCCHHH	12.48	25884760
1710	Phosphorylation	KKNKDKEYYV----- CCCCCCCCCC-----	18.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRX2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRX2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRX2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NLGN1_HUMAN	NLGN1	physical	8576240
NLGN2_HUMAN	NLGN2	physical	8576240
MACF1_HUMAN	MACF1	physical	12421765

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.