MYOZ3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYOZ3_HUMAN
• UniProt AC: Q8TDC0
• Protein Name: Myozenin-3
• Gene Name: MYOZ3 {ECO:0000312|HGNC:HGNC:18565}
• Organism: Homo sapiens (Human).
• Sequence Length: 251
• Subcellular Localization: Cytoplasm, myofibril, sarcomere, Z line. Localized at the Z-line of skeletal muscle..
• Protein Description: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis..
• Protein Sequence: MIPKEQKGPVMAAMGDLTEPVPTLDLGKKLSVPQDLMMEELSLRNNRGSLLFQKRQRRVQKFTFELAASQRAMLAGSARRKVTGTAESGTVANANGPEGPNYRSELHIFPASPGASLGGPEGAHPAAAPAGCVPSPSALAPGYAEPLKGVPPEKFNHTAISKGYRCPWQEFVSYRDYQSDGRSHTPSPNDYRNFNKTPVPFGGPLVGGTFPRPGTPFIPEPLSGLELLRLRPSFNRVAQGWVRNLPESEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	LDLGKKLSVPQDLMM CCCCCCCCCCHHHHH	40.40	23828894
42	Phosphorylation	DLMMEELSLRNNRGS HHHHHHHHHHCCCCC	28.67	23828894
49	Phosphorylation	SLRNNRGSLLFQKRQ HHHCCCCCHHHHHHH	20.75	26437602
77	Phosphorylation	QRAMLAGSARRKVTG HHHHHHHHCCCCCCC	17.00	26437602
102	Phosphorylation	NGPEGPNYRSELHIF CCCCCCCCCCEEEEE	20.74	-
104	Phosphorylation	PEGPNYRSELHIFPA CCCCCCCCEEEEEEC	33.86	26437602
112	Phosphorylation	ELHIFPASPGASLGG EEEEEECCCCCCCCC	24.89	26437602
135	Phosphorylation	APAGCVPSPSALAPG CCCCCCCCHHHCCCC	15.87	26437602
154	Ubiquitination	LKGVPPEKFNHTAIS CCCCCHHHCCCCCCC	58.18	30230243
183	Phosphorylation	DYQSDGRSHTPSPND CCCCCCCCCCCCCCC	36.92	26437602
185	Phosphorylation	QSDGRSHTPSPNDYR CCCCCCCCCCCCCCC	27.06	26437602
187	Phosphorylation	DGRSHTPSPNDYRNF CCCCCCCCCCCCCCC	37.17	26437602
209	Phosphorylation	GGPLVGGTFPRPGTP CCCCCCCCCCCCCCC	25.25	-
215	Phosphorylation	GTFPRPGTPFIPEPL CCCCCCCCCCCCCCC	20.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYOZ3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYOZ3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYOZ3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TELT_HUMAN	TCAP	physical	11842093
FLNC_HUMAN	FLNC	physical	11842093

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.