MOK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MOK_HUMAN
• UniProt AC: Q9UQ07
• Protein Name: MAPK/MAK/MRK overlapping kinase
• Gene Name: MOK
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Cytoplasm . Cell projection, cilium . Nucleus .
• Protein Description: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner..
• Protein Sequence: MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPNILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQEQRKTEKRALGSHRKAGFPEHPVAPEPLSNSCQISKEGRKQKQSLKQEEDRPKRRGPAYVMELPKLKLSGVVRLSSYSSPTLQSVLGSGTNGRVPVLRPLKCIPASKKTDPQKDLKPAPQQCRLPTIVRKGGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	QSLRDGNYYACKQMK HHCCCCCCHHHHHHH	9.66	18083107
33	Ubiquitination	DGNYYACKQMKQRFE CCCCHHHHHHHHHHH	45.30	32015554
75	Phosphorylation	EVVFDRKSGSLALIC EEEEECCCCHHHHHH	34.21	22210691
77	Phosphorylation	VFDRKSGSLALICEL EEECCCCHHHHHHHH	19.98	22210691
100	Ubiquitination	IRGRRYPLSEKKIMH HCCCCCCCCHHHHHH	8.39	29967540
115	Phosphorylation	YMYQLCKSLDHIHRN HHHHHHHHCCHHHHC	37.72	26657352
130	Ubiquitination	GIFHRDVKPENILIK CCCCCCCCHHHEEEE	51.40	29967540
151	Phosphorylation	GDFGSCRSVYSKQPY CCCCCCCCCCCCCCC	29.72	27134283
159	Phosphorylation	VYSKQPYTEYISTRW CCCCCCCCEEECCCE	29.06	10421840
161	Phosphorylation	SKQPYTEYISTRWYR CCCCCCEEECCCEEE	7.74	10421840
220	Phosphorylation	KIHDVIGTPAQKILT HHHHHHCCHHHHHHH	12.34	-
232	Phosphorylation	ILTKFKQSRAMNFDF HHHHHHHHHCCCCCC	23.69	28387310
298	Phosphorylation	TEKRALGSHRKAGFP HHHHHHHHHHCCCCC	22.44	23532336
330	Phosphorylation	EGRKQKQSLKQEEDR HHHHHHHHHHCCCCC	44.57	29485707

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MOK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MOK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MOK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAB45_HUMAN	SDF4	physical	23602568
INSR_HUMAN	INSR	physical	23602568
ZN223_HUMAN	ZNF223	physical	23602568
HUWE1_HUMAN	HUWE1	physical	23602568
WDR18_HUMAN	WDR18	physical	23602568
H13_HUMAN	HIST1H1D	physical	26186194
PNPO_HUMAN	PNPO	physical	26186194
NAA50_HUMAN	NAA50	physical	26186194
PNPO_HUMAN	PNPO	physical	28514442
H13_HUMAN	HIST1H1D	physical	28514442
NAA50_HUMAN	NAA50	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.