MOK_HUMAN - dbPTM
MOK_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MOK_HUMAN
UniProt AC Q9UQ07
Protein Name MAPK/MAK/MRK overlapping kinase
Gene Name MOK
Organism Homo sapiens (Human).
Sequence Length 419
Subcellular Localization Cytoplasm . Cell projection, cilium . Nucleus .
Protein Description Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner..
Protein Sequence MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPNILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQEQRKTEKRALGSHRKAGFPEHPVAPEPLSNSCQISKEGRKQKQSLKQEEDRPKRRGPAYVMELPKLKLSGVVRLSSYSSPTLQSVLGSGTNGRVPVLRPLKCIPASKKTDPQKDLKPAPQQCRLPTIVRKGGR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationQSLRDGNYYACKQMK
HHCCCCCCHHHHHHH
9.6618083107
33UbiquitinationDGNYYACKQMKQRFE
CCCCHHHHHHHHHHH
45.3032015554
75PhosphorylationEVVFDRKSGSLALIC
EEEEECCCCHHHHHH
34.2122210691
77PhosphorylationVFDRKSGSLALICEL
EEECCCCHHHHHHHH
19.9822210691
100UbiquitinationIRGRRYPLSEKKIMH
HCCCCCCCCHHHHHH
8.3929967540
115PhosphorylationYMYQLCKSLDHIHRN
HHHHHHHHCCHHHHC
37.7226657352
130UbiquitinationGIFHRDVKPENILIK
CCCCCCCCHHHEEEE
51.4029967540
151PhosphorylationGDFGSCRSVYSKQPY
CCCCCCCCCCCCCCC
29.7227134283
159PhosphorylationVYSKQPYTEYISTRW
CCCCCCCCEEECCCE
29.0610421840
161PhosphorylationSKQPYTEYISTRWYR
CCCCCCEEECCCEEE
7.7410421840
220PhosphorylationKIHDVIGTPAQKILT
HHHHHHCCHHHHHHH
12.34-
232PhosphorylationILTKFKQSRAMNFDF
HHHHHHHHHCCCCCC
23.6928387310
298PhosphorylationTEKRALGSHRKAGFP
HHHHHHHHHHCCCCC
22.4423532336
330PhosphorylationEGRKQKQSLKQEEDR
HHHHHHHHHHCCCCC
44.5729485707

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MOK_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MOK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MOK_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAB45_HUMANSDF4physical
23602568
INSR_HUMANINSRphysical
23602568
ZN223_HUMANZNF223physical
23602568
HUWE1_HUMANHUWE1physical
23602568
WDR18_HUMANWDR18physical
23602568
H13_HUMANHIST1H1Dphysical
26186194
PNPO_HUMANPNPOphysical
26186194
NAA50_HUMANNAA50physical
26186194
PNPO_HUMANPNPOphysical
28514442
H13_HUMANHIST1H1Dphysical
28514442
NAA50_HUMANNAA50physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MOK_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP