UniProt ID | MOK_HUMAN | |
---|---|---|
UniProt AC | Q9UQ07 | |
Protein Name | MAPK/MAK/MRK overlapping kinase | |
Gene Name | MOK | |
Organism | Homo sapiens (Human). | |
Sequence Length | 419 | |
Subcellular Localization | Cytoplasm . Cell projection, cilium . Nucleus . | |
Protein Description | Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.. | |
Protein Sequence | MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPNILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQEQRKTEKRALGSHRKAGFPEHPVAPEPLSNSCQISKEGRKQKQSLKQEEDRPKRRGPAYVMELPKLKLSGVVRLSSYSSPTLQSVLGSGTNGRVPVLRPLKCIPASKKTDPQKDLKPAPQQCRLPTIVRKGGR | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
29 | Phosphorylation | QSLRDGNYYACKQMK HHCCCCCCHHHHHHH | 9.66 | 18083107 | |
33 | Ubiquitination | DGNYYACKQMKQRFE CCCCHHHHHHHHHHH | 45.30 | 32015554 | |
75 | Phosphorylation | EVVFDRKSGSLALIC EEEEECCCCHHHHHH | 34.21 | 22210691 | |
77 | Phosphorylation | VFDRKSGSLALICEL EEECCCCHHHHHHHH | 19.98 | 22210691 | |
100 | Ubiquitination | IRGRRYPLSEKKIMH HCCCCCCCCHHHHHH | 8.39 | 29967540 | |
115 | Phosphorylation | YMYQLCKSLDHIHRN HHHHHHHHCCHHHHC | 37.72 | 26657352 | |
130 | Ubiquitination | GIFHRDVKPENILIK CCCCCCCCHHHEEEE | 51.40 | 29967540 | |
151 | Phosphorylation | GDFGSCRSVYSKQPY CCCCCCCCCCCCCCC | 29.72 | 27134283 | |
159 | Phosphorylation | VYSKQPYTEYISTRW CCCCCCCCEEECCCE | 29.06 | 10421840 | |
161 | Phosphorylation | SKQPYTEYISTRWYR CCCCCCEEECCCEEE | 7.74 | 10421840 | |
220 | Phosphorylation | KIHDVIGTPAQKILT HHHHHHCCHHHHHHH | 12.34 | - | |
232 | Phosphorylation | ILTKFKQSRAMNFDF HHHHHHHHHCCCCCC | 23.69 | 28387310 | |
298 | Phosphorylation | TEKRALGSHRKAGFP HHHHHHHHHHCCCCC | 22.44 | 23532336 | |
330 | Phosphorylation | EGRKQKQSLKQEEDR HHHHHHHHHHCCCCC | 44.57 | 29485707 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MOK_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MOK_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MOK_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
CAB45_HUMAN | SDF4 | physical | 23602568 | |
INSR_HUMAN | INSR | physical | 23602568 | |
ZN223_HUMAN | ZNF223 | physical | 23602568 | |
HUWE1_HUMAN | HUWE1 | physical | 23602568 | |
WDR18_HUMAN | WDR18 | physical | 23602568 | |
H13_HUMAN | HIST1H1D | physical | 26186194 | |
PNPO_HUMAN | PNPO | physical | 26186194 | |
NAA50_HUMAN | NAA50 | physical | 26186194 | |
PNPO_HUMAN | PNPO | physical | 28514442 | |
H13_HUMAN | HIST1H1D | physical | 28514442 | |
NAA50_HUMAN | NAA50 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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