S41A3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S41A3_HUMAN
• UniProt AC: Q96GZ6
• Protein Name: Solute carrier family 41 member 3
• Gene Name: SLC41A3
• Organism: Homo sapiens (Human).
• Sequence Length: 507
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Sequence: MDGTETRQRRLDSCGKPGELGLPHPLSTGGLPVASEDGALRAPESQSVTPKPLETEPSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQHWPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQIDDPQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCASSVLTAFLAAFALGVLMVCIVIGARKLGVNPDNIATPIAASLGDLITLSILALVSSFFYRHKDSRYLTPLVCLSFAALTPVWVLIAKQSPPIVKILKFGWFPIILAMVISSFGGLILSKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMWSAPGVLPLQMKKFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLGSSSVGHTAAVPRRCTASPGWGLIQPFICTQHLIVSLLSFYFPFCLLAKTSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	TRQRRLDSCGKPGEL HHHHHHHCCCCCCCC	29.39	29255136
27	Phosphorylation	LGLPHPLSTGGLPVA CCCCCCCCCCCCCEE	29.47	26657352
28	Phosphorylation	GLPHPLSTGGLPVAS CCCCCCCCCCCCEEC	42.84	30108239
35	Phosphorylation	TGGLPVASEDGALRA CCCCCEECCCCCCCC	36.13	23927012
45	Phosphorylation	GALRAPESQSVTPKP CCCCCCCCCCCCCCC	27.05	29255136
47	Phosphorylation	LRAPESQSVTPKPLE CCCCCCCCCCCCCCC	36.92	29255136
49	Phosphorylation	APESQSVTPKPLETE CCCCCCCCCCCCCCC	30.73	26657352
55	Phosphorylation	VTPKPLETEPSRETT CCCCCCCCCCCCCCC	61.96	29523821
58	Phosphorylation	KPLETEPSRETTWSI CCCCCCCCCCCCCEE	36.19	29523821
119	Phosphorylation	LKGNLEMTLASRLST CCCCHHHHHHHHHHH	15.14	29083192
122	Phosphorylation	NLEMTLASRLSTAAN CHHHHHHHHHHHCHH	36.55	29083192
125	Phosphorylation	MTLASRLSTAANTGQ HHHHHHHHHCHHCCC	18.19	29083192
126	Phosphorylation	TLASRLSTAANTGQI HHHHHHHHCHHCCCC	34.09	29083192
130	Phosphorylation	RLSTAANTGQIDDPQ HHHHCHHCCCCCCHH	26.24	29083192
212	Methylation	CIVIGARKLGVNPDN HHHHHHHHCCCCHHH	49.40	-
212 (in isoform 6)	Methylation	-	49.40	-
224 (in isoform 6)	Methylation	-	4.31	-
273	Methylation	PVWVLIAKQSPPIVK CHHHHHHCCCCCHHH	44.29	23644510
275	Phosphorylation	WVLIAKQSPPIVKIL HHHHHCCCCCHHHHH	31.75	22817900
309	Ubiquitination	ILSKTVSKQQYKGMA HHHCCCCHHHHCCCE	36.76	-
363 (in isoform 8)	Phosphorylation	-	26.27	27067055
367 (in isoform 8)	Phosphorylation	-	25.79	27067055
424 (in isoform 6)	Ubiquitination	-	10.62	21906983
431 (in isoform 6)	Phosphorylation	-	14.33	27067055
435 (in isoform 6)	Phosphorylation	-	9.59	27067055
447 (in isoform 7)	Ubiquitination	-	9.29	21906983
454 (in isoform 7)	Phosphorylation	-	5.75	27067055
458 (in isoform 7)	Phosphorylation	-	27.52	27067055
464 (in isoform 5)	Ubiquitination	-	10.78	21906983
471 (in isoform 5)	Phosphorylation	-	28.49	27067055
473	Ubiquitination	VPRRCTASPGWGLIQ CCCCCCCCCCCCCHH	13.04	-
475 (in isoform 5)	Phosphorylation	-	28.70	27067055
480 (in isoform 9)	Phosphorylation	-	31.71	27067055
484 (in isoform 9)	Phosphorylation	-	2.83	27067055

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S41A3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S41A3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S41A3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NHRF4_HUMAN	PDZD3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.