NEUFC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEUFC_HUMAN
• UniProt AC: Q8WUJ1
• Protein Name: Neuferricin
• Gene Name: CYB5D2 {ECO:0000312|HGNC:HGNC:28471}
• Organism: Homo sapiens (Human).
• Sequence Length: 264
• Subcellular Localization: Secreted.
• Protein Description: Heme-binding protein which promotes neuronal but not astrocyte differentiation..
• Protein Sequence: MLRCGGRGLLLGLAVAAAAVMAARLMGWWGPRAGFRLFIPEELSRYRGGPGDPGLYLALLGRVYDVSSGRRHYEPGSHYSGFAGRDASRAFVTGDCSEAGLVDDVSDLSAAEMLTLHNWLSFYEKNYVCVGRVTGRFYGEDGLPTPALTQVEAAITRGLEANKLQLQEKQTFPPCNAEWSSARGSRLWCSQKSGGVSRDWIGVPRKLYKPGAKEPRCVCVRTTGPPSGQMPDNPPHRNRGDLDHPNLAEYTGCPPLAITCSFPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Ubiquitination	SRYRGGPGDPGLYLA HHHCCCCCCHHHHHH	57.95	29967540
163	Ubiquitination	TRGLEANKLQLQEKQ HHCHHHHCCCCCCCC	44.66	29967540
208	Phosphorylation	IGVPRKLYKPGAKEP CCCCHHHCCCCCCCC	20.40	-
227	Phosphorylation	VRTTGPPSGQMPDNP EEECCCCCCCCCCCC	44.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEUFC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEUFC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEUFC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPTX2_HUMAN	NPTX2	physical	28514442
ATRAP_HUMAN	AGTRAP	physical	28514442
PTX3_HUMAN	PTX3	physical	28514442
ABLM1_HUMAN	ABLIM1	physical	28514442
NPTXR_HUMAN	NPTXR	physical	28514442
GRAP1_HUMAN	GRIPAP1	physical	28514442
ZNT5_HUMAN	SLC30A5	physical	28514442
PDIP3_HUMAN	POLDIP3	physical	28514442
KLH42_HUMAN	KLHL42	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.