CEP41_HUMAN - dbPTM
CEP41_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CEP41_HUMAN
UniProt AC Q9BYV8
Protein Name Centrosomal protein of 41 kDa
Gene Name CEP41
Organism Homo sapiens (Human).
Sequence Length 373
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Localizes mainly to the cilium basal body and in primary cilia.
Protein Description Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium..
Protein Sequence MSLRRHIGNPEYLMKRIPQNPRYQHIKSRLDTGNSMTKYTEKLEEIKKNYRYKKDELFKRLKVTTFAQLIIQVASLSDQTLEVTAEEIQRLEDNDSAASDPDAETTARTNGKGNPGEQSPSPEQFINNAGAGDSSRSTLQSVISGVGELDLDKGPVKKAEPHTKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKNAHGKIIILYDDDERLASQAATTMCERGFENLFMLSGGLKVLAQKFPEGLITGSLPASCQQALPPGSARKRSSPKGPPLPAENKWRFTPEDLKKIEYYLEEEQGPADHPSRLNQANSSGRESKVPGARSAQNLPGGGPASHSNPRSLSSGHLQGKPWK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSLRRHIGN
------CCCHHCCCC		30.5026074081
12PhosphorylationRHIGNPEYLMKRIPQ
HCCCCHHHHHHHCCC		17.2228796482
19UbiquitinationYLMKRIPQNPRYQHI
HHHHHCCCCCCHHHH		70.9124816145
32O-linked_GlycosylationHIKSRLDTGNSMTKY
HHHHHHHCCCCHHHH		42.7430379171
35PhosphorylationSRLDTGNSMTKYTEK
HHHHCCCCHHHHHHH		29.2227251275
38UbiquitinationDTGNSMTKYTEKLEE
HCCCCHHHHHHHHHH		41.3524816145
54UbiquitinationKKNYRYKKDELFKRL
HHHHCCCHHHHHHHH		47.7224816145
96PhosphorylationQRLEDNDSAASDPDA
HHHHCCCCCCCCCCH		31.8030108239
99PhosphorylationEDNDSAASDPDAETT
HCCCCCCCCCCHHHH		49.7621712546
105PhosphorylationASDPDAETTARTNGK
CCCCCHHHHHCCCCC		27.7230108239
106PhosphorylationSDPDAETTARTNGKG
CCCCHHHHHCCCCCC		12.9726699800
109PhosphorylationDAETTARTNGKGNPG
CHHHHHCCCCCCCCC		45.9522468782
119PhosphorylationKGNPGEQSPSPEQFI
CCCCCCCCCCHHHHH		24.0423401153
121PhosphorylationNPGEQSPSPEQFINN
CCCCCCCCHHHHHHC		46.4425159151
134PhosphorylationNNAGAGDSSRSTLQS
HCCCCCCCCHHHHHH		27.0823186163
135PhosphorylationNAGAGDSSRSTLQSV
CCCCCCCCHHHHHHH		34.6823186163
137PhosphorylationGAGDSSRSTLQSVIS
CCCCCCHHHHHHHHH		35.1023403867
138PhosphorylationAGDSSRSTLQSVISG
CCCCCHHHHHHHHHC		27.9223403867
141PhosphorylationSSRSTLQSVISGVGE
CCHHHHHHHHHCCCC		25.2423403867
144PhosphorylationSTLQSVISGVGELDL
HHHHHHHHCCCCCCC		25.8524173317
282PhosphorylationQQALPPGSARKRSSP
HHCCCCCCCCCCCCC		30.5825159151
287PhosphorylationPGSARKRSSPKGPPL
CCCCCCCCCCCCCCC		54.7723403867
288PhosphorylationGSARKRSSPKGPPLP
CCCCCCCCCCCCCCC		34.3623403867
312PhosphorylationEDLKKIEYYLEEEQG
HHHHHHHHHHHHHCC		19.4722817900
313PhosphorylationDLKKIEYYLEEEQGP
HHHHHHHHHHHHCCC		8.5427642862
332PhosphorylationSRLNQANSSGRESKV
HHHHHHCCCCCCCCC		36.8725002506
333PhosphorylationRLNQANSSGRESKVP
HHHHHCCCCCCCCCC		41.5025002506
337PhosphorylationANSSGRESKVPGARS
HCCCCCCCCCCCCCC		37.2828857561
343MethylationESKVPGARSAQNLPG
CCCCCCCCCCCCCCC		38.14-
344PhosphorylationSKVPGARSAQNLPGG
CCCCCCCCCCCCCCC		33.4026657352
355PhosphorylationLPGGGPASHSNPRSL
CCCCCCCCCCCCCCC		30.4927174698
357PhosphorylationGGGPASHSNPRSLSS
CCCCCCCCCCCCCCC		46.1427174698
361PhosphorylationASHSNPRSLSSGHLQ
CCCCCCCCCCCCCCC		33.5823403867
363PhosphorylationHSNPRSLSSGHLQGK
CCCCCCCCCCCCCCC		35.2023401153
364PhosphorylationSNPRSLSSGHLQGKP
CCCCCCCCCCCCCCC		35.2123403867
370AcetylationSSGHLQGKPWK----
CCCCCCCCCCC----		34.4423954790
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CEP41_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CEP41_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CEP41_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HIP1R_HUMANHIP1Rphysical
26344197
MB12A_HUMANMVB12Aphysical
26344197
SYWC_HUMANWARSphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614464Joubert syndrome 15 (JBTS15)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CEP41_HUMAN

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Related Literatures of Post-Translational Modification

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