DCDC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCDC2_HUMAN
• UniProt AC: Q9UHG0
• Protein Name: Doublecortin domain-containing protein 2
• Gene Name: DCDC2
• Organism: Homo sapiens (Human).
• Sequence Length: 476
• Subcellular Localization: Cell projection, cilium . Cytoplasm, cytoskeleton, cilium axoneme . Cell projection, kinocilium . Cytoplasm, cytoskeleton . Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner.
• Protein Description: Protein that plays a role in the inhibition of canonical Wnt signaling pathway. [PubMed: 25557784 May be involved in neuronal migration during development of the cerebral neocortex (By similarity Involved in the control of ciliogenesis and ciliary length]
• Protein Sequence: MSGSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	LSQPVVKSVLVYRNG CCCCCEEEEEEEECC	14.74	-
22	Phosphorylation	VVKSVLVYRNGDPFY CEEEEEEEECCCCCC	8.32	-
29	Phosphorylation	YRNGDPFYAGRRVVI EECCCCCCCCEEEEE	17.34	30622161
42	Phosphorylation	VIHEKKVSSFEVFLK EEEEECCCEEEHHHH	37.88	22673903
43	Phosphorylation	IHEKKVSSFEVFLKE EEEECCCEEEHHHHH	28.54	22673903
67	Phosphorylation	GAVRNIYTPRTGHRI CCCCCEECCCCCCCE	11.51	24719451
86	Phosphorylation	QIQSGGNYVAGGQEA HHHCCCCCCCCHHHH	8.58	27642862
99	Phosphorylation	EAFKKLNYLDIGEIK HHHHHCCCCCHHHCC	19.04	19664994
106	Ubiquitination	YLDIGEIKKRPMEVV CCCHHHCCCCCCEEE	38.13	33845483
128	Phosphorylation	IHSRINVSARFRKPL EECEECCCHHCCCCC	14.83	24670416
178	Phosphorylation	QMVTEKITLRSGAVH HHHHHHEEECCCCCE	27.47	22210691
181	Phosphorylation	TEKITLRSGAVHRLY HHHEEECCCCCEEEE	33.93	22210691
220	Phosphorylation	DKFKKLPYSELLFDK HHCCCCCHHHHCCCC	25.80	29514088
221	Phosphorylation	KFKKLPYSELLFDKS HCCCCCHHHHCCCCC	21.59	29514088
228	Phosphorylation	SELLFDKSTMRRPFG HHHCCCCCCCCCCCC	29.31	21712546
229	Phosphorylation	ELLFDKSTMRRPFGQ HHCCCCCCCCCCCCC	22.04	21712546
239	Phosphorylation	RPFGQKASSLPPIVG CCCCCCHHCCCCCCC	39.17	24719451
240	Phosphorylation	PFGQKASSLPPIVGS CCCCCHHCCCCCCCC	50.16	28857561
247	Phosphorylation	SLPPIVGSRKSKGSG CCCCCCCCCCCCCCC	26.16	28857561
251	Methylation	IVGSRKSKGSGNDRH CCCCCCCCCCCCCCC	61.19	-
259	Phosphorylation	GSGNDRHSKSTVGSS CCCCCCCCCCCCCCC	29.24	28857561
261	Phosphorylation	GNDRHSKSTVGSSDN CCCCCCCCCCCCCCC	31.19	28857561
262	Phosphorylation	NDRHSKSTVGSSDNS CCCCCCCCCCCCCCC	32.40	28857561
265	Phosphorylation	HSKSTVGSSDNSSPQ CCCCCCCCCCCCCCC	30.13	28857561
266	Phosphorylation	SKSTVGSSDNSSPQP CCCCCCCCCCCCCCC	34.58	28857561
269	Phosphorylation	TVGSSDNSSPQPLKR CCCCCCCCCCCCCCC	48.67	25849741
270	Phosphorylation	VGSSDNSSPQPLKRK CCCCCCCCCCCCCCC	33.53	28355574
285	Phosphorylation	GKKEDVNSEKLTKLK CCHHHCCHHHHHHHH	35.64	22617229
300	Phosphorylation	QNVKLKNSQETIPNS HHHCCCCCCCCCCCC	28.01	25849741
303	Phosphorylation	KLKNSQETIPNSDEG CCCCCCCCCCCCCCC	33.81	29116813
307	Phosphorylation	SQETIPNSDEGIFKA CCCCCCCCCCCCHHH	31.52	26330541
382	Phosphorylation	EEGGREATDAPEQVE HCCCCCCCCCHHHHH	28.13	-
433	Phosphorylation	VLDKERKSQGAGSGQ HHCHHHHHCCCCCCC	39.82	25849741
438	Phosphorylation	RKSQGAGSGQDEADV HHHCCCCCCCCCCCC	32.52	29116813

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCDC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCDC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCDC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NIF3L_HUMAN	NIF3L1	physical	25416956
MOFA1_HUMAN	MRFAP1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 600202: Dyslexia 2 (DYX2)
• 616217: Nephronophthisis 19 (NPHP19)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.