TNIP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNIP3_HUMAN
• UniProt AC: Q96KP6
• Protein Name: TNFAIP3-interacting protein 3
• Gene Name: TNIP3 {ECO:0000312|HGNC:HGNC:19315}
• Organism: Homo sapiens (Human).
• Sequence Length: 325
• Protein Description: Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding..
• Protein Sequence: MAHFVQGTSRMIAAESSTEHKECAEPSTRKNLMNSLEQKIRCLEKQRKELLEVNQQWDQQFRSMKELYERKVAELKTKLDAAERFLSTREKDPHQRQRKDDRQREDDRQRDLTRDRLQREEKEKERLNEELHELKEENKLLKGKNTLANKEKEHYECEIKRLNKALQDALNIKCSFSEDCLRKSRVEFCHEEMRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEELQQINETSQSQLNRLNSQIKACQMEKEKLEKQLKQMYCPPCNCGLVFHLQDPWVPTGPGAVQKQREHPPDYQWYALDQLPPDVQHKANGLSSVKKVHP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAHFVQGTSRMIAAE CCCCCCHHHHHHHCC	8.96	29759185
35	Phosphorylation	TRKNLMNSLEQKIRC HHHHHHHHHHHHHHH	21.22	26699800
39	Trimethylation	LMNSLEQKIRCLEKQ HHHHHHHHHHHHHHH	23.81	-
39	Methylation	LMNSLEQKIRCLEKQ HHHHHHHHHHHHHHH	23.81	23644510
68	Phosphorylation	FRSMKELYERKVAEL HHHHHHHHHHHHHHH	18.12	-
175	Phosphorylation	DALNIKCSFSEDCLR HHHCCCCCCCHHHHH	27.14	28258704
195	Phosphorylation	FCHEEMRTEMEVLKQ HHHHHHHHHHHHHHH	38.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNIP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNIP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNIP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LZTS2_HUMAN	LZTS2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.