dbPTM

HMGA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HMGA2_MOUSE
UniProt AC	P52927
Protein Name	High mobility group protein HMGI-C
Gene Name	Hmga2
Organism	Mus musculus (Mouse).
Sequence Length	108
Subcellular Localization	Nucleus .
Protein Description	Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation. [PubMed: 27446912]
Protein Sequence	MSARGEGAGQPSTSAQGQPAAPVPQKRGRGRPRKQQQEPTCEPSPKRPRGRPKGSKNKSPSKAAQKKAETIGEKRPRGRPRKWPQQVVQKKPAQETEETSSQESAEED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSARGEGAG ------CCCCCCCCC	27.03	26824392
2	Acetylation	------MSARGEGAG ------CCCCCCCCC	27.03	-
12	Phosphorylation	GEGAGQPSTSAQGQP CCCCCCCCCCCCCCC	27.40	28059163
13	Phosphorylation	EGAGQPSTSAQGQPA CCCCCCCCCCCCCCC	34.46	29514104
14	Phosphorylation	GAGQPSTSAQGQPAA CCCCCCCCCCCCCCC	23.96	27087446
26	Acetylation	PAAPVPQKRGRGRPR CCCCCCCCCCCCCCC	51.23	129653
27	Methylation	AAPVPQKRGRGRPRK CCCCCCCCCCCCCCC	34.49	18966559
40	Phosphorylation	RKQQQEPTCEPSPKR CCCCCCCCCCCCCCC	28.84	25619855
41	Glutathionylation	KQQQEPTCEPSPKRP CCCCCCCCCCCCCCC	12.09	24333276
44	Phosphorylation	QEPTCEPSPKRPRGR CCCCCCCCCCCCCCC	22.29	25521595
59	Phosphorylation	PKGSKNKSPSKAAQK CCCCCCCCHHHHHHH	43.74	24453211
61	Phosphorylation	GSKNKSPSKAAQKKA CCCCCCHHHHHHHHH	41.85	24453211
74	Acetylation	KAETIGEKRPRGRPR HHHHHHCCCCCCCCC	63.59	23806337
96	Phosphorylation	QKKPAQETEETSSQE HCCCCCCCCHHCCHH	27.35	25619855
99	Phosphorylation	PAQETEETSSQESAE CCCCCCHHCCHHHHH	27.69	25521595
100	Phosphorylation	AQETEETSSQESAEE CCCCCHHCCHHHHHC	33.05	25521595
101	Phosphorylation	QETEETSSQESAEED CCCCHHCCHHHHHCC	45.44	25521595
104	Phosphorylation	EETSSQESAEED--- CHHCCHHHHHCC---	33.09	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
44	S	Phosphorylation	Kinase	CDK1	P06493	PSP
59	S	Phosphorylation	Kinase	CDK1	P06493	PSP
99	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
100	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
101	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
104	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HMGA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HMGA2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TAF3_MOUSE	Taf3	physical	21417337
CAF1A_MOUSE	Chaf1a	physical	21417337

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HMGA2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, AND MASSSPECTROMETRY.	19131326 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, AND MASSSPECTROMETRY.	17242355 [Abstract]