TAF3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF3_MOUSE
• UniProt AC: Q5HZG4
• Protein Name: Transcription initiation factor TFIID subunit 3
• Gene Name: Taf3
• Organism: Mus musculus (Mouse).
• Sequence Length: 932
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process..
• Protein Sequence: MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVGEAFQLMGVNLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKDYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDEMEEEEVINDENFLGKRPLDSPEVEEMPSMKRPRLLSTKGDSLDVVLLEAREPLSSINPQKTPPVLSPVRVQDRADLAPPSPQPPMLAPFAKSQLPIAKPLETKSFTPKTKTKASSPGQKTKSPKAALSPARLGSPIRSPKTIPKEKKSPGRSKSPKSPKSPKIVAHVPQTPVRPETPNRTPSAMVVEKTVKETIPVMKPTQTPPEVVKLNIEMQPKKPVVTDKTIDDSIDAVIARACAEREPDPFEFSSGSESEGDTFTSPKRISGSECATPKASTSSNNFTKSLATPLPLSSGTSSSDNSWTMDASIDEVVRKAKLGAPSNMPPTFPYISSPSISPPTPEPLHKGYEEKAKLPSSVDVKKKLKKELKTKLKKKEKQRDRERERERNKERSKEKDKMREREKEKEAGKELKYPWRELMKDEDSDPYKFKIKEFEDIDAAKVRLKDGIVRREREKHKDKKKDRERSKREKDKRERERLKEKNREDKIKAPPTQLVLPPKEMALPLFSPSAVRVPAMLPAFSPMLPEKLFEEKEKPKEKERKKDKKEKKKKKEKEKEKEKKEREREKERREREKREKEKEKHKHEKIKVEPVIPAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSLNRPKTPPPAPVPIPVRVSPTPLQPPLLTQAAVCPALMPSPAPALSGIGSAKAPVRSVVTETVSTYVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMAAPPEEMQWFCPKCANKIKKDKKHKKRKHRAH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	Phosphorylation	LQFPQPGSKDAEERK ECCCCCCCCCHHHHH	33.76	28285833
183	Phosphorylation	LGKRPLDSPEVEEMP CCCCCCCCCCHHHCC	30.55	25521595
199	Phosphorylation	MKRPRLLSTKGDSLD CCCCCCCCCCCCCCE	32.44	26824392
200	Phosphorylation	KRPRLLSTKGDSLDV CCCCCCCCCCCCCEE	38.73	21183079
204	Phosphorylation	LLSTKGDSLDVVLLE CCCCCCCCCEEEEEE	34.83	27180971
217	Phosphorylation	LEAREPLSSINPQKT EEECCCHHHCCCCCC	39.63	25619855
218	Phosphorylation	EAREPLSSINPQKTP EECCCHHHCCCCCCC	33.78	25619855
224	Phosphorylation	SSINPQKTPPVLSPV HHCCCCCCCCCCCCC	27.81	26824392
229	Phosphorylation	QKTPPVLSPVRVQDR CCCCCCCCCCEEECC	22.91	26824392
243	Phosphorylation	RADLAPPSPQPPMLA CCCCCCCCCCCCCCH	34.80	23527152
266	Acetylation	IAKPLETKSFTPKTK CCCCCCCCCCCCCCC	33.91	23806337
269	Phosphorylation	PLETKSFTPKTKTKA CCCCCCCCCCCCCCC	30.85	24719451
291	Phosphorylation	KSPKAALSPARLGSP CCCHHHCCHHHCCCC	16.28	27149854
297	Phosphorylation	LSPARLGSPIRSPKT CCHHHCCCCCCCCCC	23.03	26824392
301	Phosphorylation	RLGSPIRSPKTIPKE HCCCCCCCCCCCCCC	31.31	26824392
304	Phosphorylation	SPIRSPKTIPKEKKS CCCCCCCCCCCCCCC	45.99	29514104
333	Phosphorylation	IVAHVPQTPVRPETP EEEECCCCCCCCCCC	20.06	28507225
339	Phosphorylation	QTPVRPETPNRTPSA CCCCCCCCCCCCCCE	28.66	28507225
343	Phosphorylation	RPETPNRTPSAMVVE CCCCCCCCCCEEEEE	28.38	26643407
345	Phosphorylation	ETPNRTPSAMVVEKT CCCCCCCCEEEEEEE	28.52	26643407
351	Acetylation	PSAMVVEKTVKETIP CCEEEEEEEHHHCCC	47.19	22826441
356	Phosphorylation	VEKTVKETIPVMKPT EEEEHHHCCCCCCCC	25.51	25159016
363	Phosphorylation	TIPVMKPTQTPPEVV CCCCCCCCCCCCCEE	39.29	25159016
365	Phosphorylation	PVMKPTQTPPEVVKL CCCCCCCCCCCEEEE	43.20	28507225
420	Phosphorylation	GSESEGDTFTSPKRI CCCCCCCCCCCCCCC	39.40	25293948
422	Phosphorylation	ESEGDTFTSPKRISG CCCCCCCCCCCCCCC	46.33	25293948
423	Phosphorylation	SEGDTFTSPKRISGS CCCCCCCCCCCCCCC	25.00	25293948
428	Phosphorylation	FTSPKRISGSECATP CCCCCCCCCCCCCCC	40.06	23375375
430	Phosphorylation	SPKRISGSECATPKA CCCCCCCCCCCCCCC	23.78	25367039
434	Phosphorylation	ISGSECATPKASTSS CCCCCCCCCCCCCCC	36.66	19060867
494	Phosphorylation	PPTFPYISSPSISPP CCCCCCCCCCCCCCC	30.28	21183079
495	Phosphorylation	PTFPYISSPSISPPT CCCCCCCCCCCCCCC	17.07	21183079
497	Phosphorylation	FPYISSPSISPPTPE CCCCCCCCCCCCCCC	37.33	26643407
499	Phosphorylation	YISSPSISPPTPEPL CCCCCCCCCCCCCCC	29.21	26643407
502	Phosphorylation	SPSISPPTPEPLHKG CCCCCCCCCCCCCCC	43.60	26643407
518	Phosphorylation	EEKAKLPSSVDVKKK HHHCCCCCCCHHHHH	54.13	28066266
519	Phosphorylation	EKAKLPSSVDVKKKL HHCCCCCCCHHHHHH	22.01	28066266
669	Phosphorylation	EMALPLFSPSAVRVP HHCCCCCCHHHCCCC	26.15	26824392
671	Phosphorylation	ALPLFSPSAVRVPAM CCCCCCHHHCCCCCC	37.89	28066266
683	Phosphorylation	PAMLPAFSPMLPEKL CCCHHHHCCCCCHHH	16.11	28833060
758	Phosphorylation	EPVIPAPSPVIPRLT EECCCCCCCCCCCEE	33.63	28066266
779	Acetylation	QDKIVISKVVPAPEA CCEEEEEEEEECCCC	35.81	23806337
787	Acetylation	VVPAPEAKPAPSLNR EEECCCCCCCCCCCC	39.80	23954790
791	Phosphorylation	PEAKPAPSLNRPKTP CCCCCCCCCCCCCCC	40.14	24719451
797	Phosphorylation	PSLNRPKTPPPAPVP CCCCCCCCCCCCCCC	43.65	21082442
810	Phosphorylation	VPIPVRVSPTPLQPP CCCCEECCCCCCCCC	16.70	25293948
812	Phosphorylation	IPVRVSPTPLQPPLL CCEECCCCCCCCCCH	29.17	25293948
820	Phosphorylation	PLQPPLLTQAAVCPA CCCCCCHHHHCCCCH	24.68	25293948
831	Phosphorylation	VCPALMPSPAPALSG CCCHHCCCCCCCCCC	21.52	25293948
837	Phosphorylation	PSPAPALSGIGSAKA CCCCCCCCCCCCCCC	30.39	25293948
841	Phosphorylation	PALSGIGSAKAPVRS CCCCCCCCCCCCHHH	25.36	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
229	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TAF3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.