| UniProt ID | CAF1A_MOUSE | |
|---|---|---|
| UniProt AC | Q9QWF0 | |
| Protein Name | Chromatin assembly factor 1 subunit A | |
| Gene Name | Chaf1a | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 911 | |
| Subcellular Localization | Nucleus. DNA replication foci. | |
| Protein Description | Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.. | |
| Protein Sequence | MLEEPEAATRTAAAVDCKDRPGFPVKRLIQARLPFKRLNLVPKEKVEEDTSPKAAVESKVPDLQLSLGTFESQCHTGSHVGLSTKLVGGQGPIDSFLRATIKPVPSVVIIDLTENCSDIPDSPEGHSELSPDTAGVVTTVEGAAKQQEHSAAELCLLETPSDITCHMEEEPGSPGDPKRTGDCQAGSLQSCPELTPGSRTCPTKELSSWSKAGDLLFIEKVPVVVLEDILATKPSIASLPMMSLDRSVTSESEILESCPEDDSILSHSSTNSSSPTSSPEGPSTPPEHRGGRSSPSTPACRVAKNFVKGSTEKGRSKLHRDREQQREEKEKLREEIRRAKEEARKKKEEEKELKEKERREKREKDEKEKAEKQRLKEEKRKERQEALEAKLEEKRKKEEEKRLREEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRCRAALDQDLCDQLDQLLQQQSVASTFLSDLKSRLPLRSGPTRVCGHDTDIMNRDVVIVESSKVDGVSERKKFGRMKLLQFSENHRPAYWGTWNKKTAIIRPRNPWAQDKDLLDYEVDSDDEWEEEEPGESLSHSEGDEDDDVGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVHQKLKAKEWDELLAKGKRFRVLQPVHVGCVWASEAANCTSSDLKLLQQFTACLLDVASPDEPEPGASRREKRDQHILAQLLPLLHGNVNGSKVIIHEFQEQCRRGLLTLPSPTPHLQMPNLEDAVAVPSKARLKRLISENSAYEKRPNFRMCWYVHPEVLKSFGQECLPVPCQWTYITTMPSAPREDSGSASTEGPGQSTPMLLKRKPAATMCITQFMKKRRYDGQVGSGDMDGFQADTEEDEEDDTDCMIIDVPDVGSDVSEAPIPAPTLCK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | Phosphorylation | KEKVEEDTSPKAAVE HHHCCCCCCCHHHHH | 50.65 | 26824392 | |
| 51 | Phosphorylation | EKVEEDTSPKAAVES HHCCCCCCCHHHHHC | 36.40 | 25263469 | |
| 58 | Phosphorylation | SPKAAVESKVPDLQL CCHHHHHCCCCCEEE | 32.14 | 25777480 | |
| 76 | Phosphorylation | TFESQCHTGSHVGLS ECCCCCCCCCCCCCC | 48.26 | 29899451 | |
| 83 | Phosphorylation | TGSHVGLSTKLVGGQ CCCCCCCCEEECCCC | 19.98 | 29899451 | |
| 100 | Phosphorylation | IDSFLRATIKPVPSV HHHHHHHCCCCCCEE | 24.09 | 25293948 | |
| 106 | Phosphorylation | ATIKPVPSVVIIDLT HCCCCCCEEEEEECC | 29.29 | 25293948 | |
| 113 | Phosphorylation | SVVIIDLTENCSDIP EEEEEECCCCCCCCC | 22.77 | 25293948 | |
| 117 | Phosphorylation | IDLTENCSDIPDSPE EECCCCCCCCCCCCC | 50.59 | 25293948 | |
| 122 | Phosphorylation | NCSDIPDSPEGHSEL CCCCCCCCCCCCCCC | 21.35 | 21659605 | |
| 127 | Phosphorylation | PDSPEGHSELSPDTA CCCCCCCCCCCCCCC | 51.60 | 25293948 | |
| 130 | Phosphorylation | PEGHSELSPDTAGVV CCCCCCCCCCCCCEE | 19.37 | 25293948 | |
| 133 | Phosphorylation | HSELSPDTAGVVTTV CCCCCCCCCCEEEEE | 28.79 | 25293948 | |
| 138 | Phosphorylation | PDTAGVVTTVEGAAK CCCCCEEEEEHHHHH | 23.79 | 25293948 | |
| 139 | Phosphorylation | DTAGVVTTVEGAAKQ CCCCEEEEEHHHHHH | 12.63 | 25293948 | |
| 150 | Phosphorylation | AAKQQEHSAAELCLL HHHHCCCCHHHHHHE | 28.55 | 22668510 | |
| 159 | Phosphorylation | AELCLLETPSDITCH HHHHHEECCCCCEEE | 28.23 | 25159016 | |
| 161 | Phosphorylation | LCLLETPSDITCHME HHHEECCCCCEEECC | 49.41 | 25159016 | |
| 164 | Phosphorylation | LETPSDITCHMEEEP EECCCCCEEECCCCC | 11.01 | 25159016 | |
| 173 | Phosphorylation | HMEEEPGSPGDPKRT ECCCCCCCCCCCCCC | 36.10 | 26824392 | |
| 180 | Phosphorylation | SPGDPKRTGDCQAGS CCCCCCCCCCCCCCC | 43.42 | 25619855 | |
| 187 | Phosphorylation | TGDCQAGSLQSCPEL CCCCCCCCCCCCCCC | 26.67 | 25619855 | |
| 190 | Phosphorylation | CQAGSLQSCPELTPG CCCCCCCCCCCCCCC | 36.61 | 25619855 | |
| 195 | Phosphorylation | LQSCPELTPGSRTCP CCCCCCCCCCCCCCC | 24.76 | 25619855 | |
| 198 | Phosphorylation | CPELTPGSRTCPTKE CCCCCCCCCCCCCCH | 26.14 | 25619855 | |
| 208 | Phosphorylation | CPTKELSSWSKAGDL CCCCHHCCCCCCCCE | 48.25 | - | |
| 243 | Phosphorylation | IASLPMMSLDRSVTS HHCCCCCCCCCCCCC | 22.36 | 29514104 | |
| 249 | Phosphorylation | MSLDRSVTSESEILE CCCCCCCCCHHHHHH | 28.20 | 22942356 | |
| 257 | Phosphorylation | SESEILESCPEDDSI CHHHHHHHCCCCCCC | 31.37 | 25338131 | |
| 263 | Phosphorylation | ESCPEDDSILSHSST HHCCCCCCCCCCCCC | 37.44 | 25338131 | |
| 283 | Phosphorylation | TSSPEGPSTPPEHRG CCCCCCCCCCCCCCC | 65.49 | 25338131 | |
| 284 | Phosphorylation | SSPEGPSTPPEHRGG CCCCCCCCCCCCCCC | 46.10 | 22668510 | |
| 293 | Phosphorylation | PEHRGGRSSPSTPAC CCCCCCCCCCCCHHH | 50.29 | 27149854 | |
| 294 | Phosphorylation | EHRGGRSSPSTPACR CCCCCCCCCCCHHHH | 22.85 | 26824392 | |
| 296 | Phosphorylation | RGGRSSPSTPACRVA CCCCCCCCCHHHHHH | 49.31 | 24899341 | |
| 297 | Phosphorylation | GGRSSPSTPACRVAK CCCCCCCCHHHHHHH | 20.49 | 25263469 | |
| 310 | Phosphorylation | AKNFVKGSTEKGRSK HHHHHCCCCHHHHHH | 27.89 | 25266776 | |
| 311 | Phosphorylation | KNFVKGSTEKGRSKL HHHHCCCCHHHHHHH | 50.84 | 25266776 | |
| 433 | Phosphorylation | RFFQKPKTPQAPKTL HHHCCCCCCCCCCCC | 29.21 | 29514104 | |
| 446 | Acetylation | TLAGSCGKFAPFEIK CCCCCCCCCCCCEEH | 42.55 | 23806337 | |
| 493 | Phosphorylation | TFLSDLKSRLPLRSG HHHHHHHHHCCCCCC | 46.47 | 21149613 | |
| 499 | Phosphorylation | KSRLPLRSGPTRVCG HHHCCCCCCCCEECC | 57.73 | 21149613 | |
| 502 | Phosphorylation | LPLRSGPTRVCGHDT CCCCCCCCEECCCCC | 38.98 | 21149613 | |
| 688 | Phosphorylation | LKLLQQFTACLLDVA HHHHHHHHHHHHHCC | 16.48 | 23984901 | |
| 696 | Phosphorylation | ACLLDVASPDEPEPG HHHHHCCCCCCCCCC | 32.50 | 23984901 | |
| 746 | Phosphorylation | QCRRGLLTLPSPTPH HHHCCCCCCCCCCCC | 41.48 | 26643407 | |
| 749 | Phosphorylation | RGLLTLPSPTPHLQM CCCCCCCCCCCCCCC | 44.51 | 26643407 | |
| 751 | Phosphorylation | LLTLPSPTPHLQMPN CCCCCCCCCCCCCCC | 27.90 | 26745281 | |
| 776 | Phosphorylation | ARLKRLISENSAYEK HHHHHHHHCCCHHHH | 35.00 | 25266776 | |
| 779 | Phosphorylation | KRLISENSAYEKRPN HHHHHCCCHHHHCCC | 28.33 | 29550500 | |
| 838 | Phosphorylation | TEGPGQSTPMLLKRK CCCCCCCCCCHHCCC | 12.58 | 22006019 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CAF1A_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CAF1A_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CAF1A_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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