SDE2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDE2_MOUSE
• UniProt AC: Q8K1J5
• Protein Name: Replication stress response regulator SDE2 {ECO:0000305}
• Gene Name: Sde2
• Organism: Mus musculus (Mouse).
• Sequence Length: 448
• Subcellular Localization: Nucleus .
• Protein Description: Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression..
• Protein Sequence: MAEAAVVAWVRGPGTVWKALPCASVGCSVRDVIYRHCQEQEVPVECFFVTCNGVLVNAGDKVQHGAVYSLEPRLRGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWVKQQAEREAEKEQRRLERLQRKLAEPAHCFTSPDYQRQCHEMAERLEDSVLKGMQAASSKMVSAEITETRKRPNKSKTDQETSAKKRKRKCFWLGMDGLEAAEGSSTGSSEDSSEDDSEDAPGTSEQSCCAREDGIDAVEVAADRPGSPRSSASGTHSESPEKLQCPVTEPGQGILENTGTEPGETSDKECNERKTVTDPEETPARKETESHEATEKDQKTGMSGGDRAAMVLSGEDRKSVPAANLEGNNSGDTALGLEAVDLSAFSSAAELESLGLERLKCELMVLGLKCGGTLQERAARLFSVRGLTKELIDPALFAKPSKGKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	GGKGGFGSMLRALGA CCCCCHHHHHHHHHC		26239621
152	Phosphorylation	AEPAHCFTSPDYQRQ HCCHHHCCCHHHHHH		28066266
153	Phosphorylation	EPAHCFTSPDYQRQC CCHHHCCCHHHHHHH		26643407
156	Phosphorylation	HCFTSPDYQRQCHEM HHCCCHHHHHHHHHH		26643407
269	Phosphorylation	VAADRPGSPRSSASG EECCCCCCCCCCCCC		24925903
272	Phosphorylation	DRPGSPRSSASGTHS CCCCCCCCCCCCCCC		25159016
273	Phosphorylation	RPGSPRSSASGTHSE CCCCCCCCCCCCCCC		25777480
275	Phosphorylation	GSPRSSASGTHSESP CCCCCCCCCCCCCCC		25777480
277	Phosphorylation	PRSSASGTHSESPEK CCCCCCCCCCCCCCC		25159016
279	Phosphorylation	SSASGTHSESPEKLQ CCCCCCCCCCCCCCC		25159016
281	Phosphorylation	ASGTHSESPEKLQCP CCCCCCCCCCCCCCC		27087446
290	Phosphorylation	EKLQCPVTEPGQGIL CCCCCCCCCCCCCHH		25777480
300	Phosphorylation	GQGILENTGTEPGET CCCHHHCCCCCCCCC		21149613
302	Phosphorylation	GILENTGTEPGETSD CHHHCCCCCCCCCCC		21149613
307	Phosphorylation	TGTEPGETSDKECNE CCCCCCCCCCCCHHC		21149613
308	Phosphorylation	GTEPGETSDKECNER CCCCCCCCCCCHHCC		27087446
317	Phosphorylation	KECNERKTVTDPEET CCHHCCCCCCCCCCC		27180971
324	Phosphorylation	TVTDPEETPARKETE CCCCCCCCCCHHHCC		27180971
330	Phosphorylation	ETPARKETESHEATE CCCCHHHCCCCCCCH		30482847
332	Phosphorylation	PARKETESHEATEKD CCHHHCCCCCCCHHH		29895711
355	Phosphorylation	DRAAMVLSGEDRKSV CCEEEEECCCCCCCC		-
431	Ubiquitination	FSVRGLTKELIDPAL HCHHCHHHHHCCHHH		22790023
441	Acetylation	IDPALFAKPSKGKKK CCHHHHCCCCCCCCC		23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDE2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
77	G	ubiquitylation	The protein is cleaved at Gly-77 by a deubiquitinating enzyme to form the active SDE2.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDE2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SDE2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.