ASF1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASF1A_MOUSE
• UniProt AC: Q9CQE6
• Protein Name: Histone chaperone ASF1A
• Gene Name: Asf1a
• Organism: Mus musculus (Mouse).
• Sequence Length: 204
• Subcellular Localization: Nucleus .
• Protein Description: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit..
• Protein Sequence: MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNAGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
157	Phosphorylation	HINWEDNTEKLEDAE EEECCCCHHHHHHHH	46.98	26745281
159	Ubiquitination	NWEDNTEKLEDAESS ECCCCHHHHHHHHHC	55.95	-
165	Phosphorylation	EKLEDAESSNPNLQS HHHHHHHHCCCCHHH	36.82	27087446
166	Phosphorylation	KLEDAESSNPNLQSL HHHHHHHCCCCHHHH	48.05	27087446
172	Phosphorylation	SSNPNLQSLLSTDAL HCCCCHHHHHCCCCC	34.15	27600695
175	Phosphorylation	PNLQSLLSTDALPSA CCHHHHHCCCCCCCC	29.54	30352176
176	Phosphorylation	NLQSLLSTDALPSAS CHHHHHCCCCCCCCC	25.84	28066266
181	Phosphorylation	LSTDALPSASKGWST HCCCCCCCCCCCCCC	46.13	28066266
187	Phosphorylation	PSASKGWSTSENSLN CCCCCCCCCCCHHHH	30.62	27600695
188	Phosphorylation	SASKGWSTSENSLNV CCCCCCCCCCHHHHH	33.29	27600695
192	Phosphorylation	GWSTSENSLNVMLES CCCCCCHHHHHHHHH	19.78	27600695

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
166	S	Phosphorylation	Kinase	TLK2	O55047	PSP
192	S	Phosphorylation	Kinase	TLK2	O55047	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
192	S	Phosphorylation	TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASF1A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAF1A_MOUSE	Chaf1a	physical	26365490

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.