| UniProt ID | TIM_MOUSE | |
|---|---|---|
| UniProt AC | Q9R1X4 | |
| Protein Name | Protein timeless homolog | |
| Gene Name | Timeless {ECO:0000312|MGI:MGI:1321393} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1197 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.. | |
| Protein Sequence | MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFGSVPKDSSVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKSIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQTPEQLAGVGQGRLAQERSTDVAELEVLRQREMAEKRARALQRGNRHSRFGGSYIVQGLKSIGEKDVVFHKGLHNLQNYSSDLGKQPRRVPKRRQAAQELSVHRRSVLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLRERAQQHDETYYMWAMAFFMAFNRAATFRPGLVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDEAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHLFLKMLERFCRSRGNLMVQNKRKKRKKKKKVQDQGVAFSQSPGELEAMWPALAEQLLQCAQDPELSVDPVVPFDAASEVPVEEQRVEAMVRIQDCLTAGQAPQALALLRSAREVWPEGNAFGSPVISPGEEMQLLKQILSTPLPRQQEPEEGDAEEEEEEEEEEELQVVQVSEKEFNFLEYLKRFASSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHGLGMEALLFQLSLFCLFNRLLSDPAAAAYKELVTFAKYIIGKFFALAAVNQKAFVELLFWKNTAVVREMTQGYGSLDSGSSSHRAPLWSPEEEAQLQELYLAHKDVEGQDVVETILAHLKVVPRTRKQVIHHLVRMGLADSVKEFQKRKGTQIVLWTEDQELELQRLFEEFRDSDDVLGQIMKNITAKRSRARVVDKLLALGLVSERRQLYKKRRKKLAPSCMQNGEKSPRDPWQEDPEEEDEHLPEDESEDEESEEGLPSGQGQGSSSLSAENLGESLRQEGLSAPLLWLQSSLIRAANDREEDGCSQAIPLVPLTEENEEAMENEQFQHLLRKLGIRPPSSGQETFWRIPAKLSSTQLRRVAASLSQQENEEEREEEPEPGVPGEQGPSEEHRTEALRALLSARKRKAGLGPTEEEATGEEEWNSAPKKRQLLDSDEEEDDEGRRQAVSGTPRVHRKKRFQIEDEDD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 228 (in isoform 4) | Phosphorylation | - | 45.50 | 29895711 | |
| 281 | Phosphorylation | RHSRFGGSYIVQGLK CCCCCCCCHHHHCCH | 16.44 | - | |
| 288 | Acetylation | SYIVQGLKSIGEKDV CHHHHCCHHCCCCCE | 47.02 | 22826441 | |
| 299 | Acetylation | EKDVVFHKGLHNLQN CCCEEECHHHHHHHH | 52.26 | 22826441 | |
| 750 | Phosphorylation | CLFNRLLSDPAAAAY HHHHHHCCCHHHHHH | 46.25 | 24759943 | |
| 798 | Phosphorylation | TAVVREMTQGYGSLD HHHHHHHHCCCCCCC | 17.68 | 21183079 | |
| 940 | Acetylation | SERRQLYKKRRKKLA HHHHHHHHHHHHHHH | 48.69 | 6566487 | |
| 941 | Acetylation | ERRQLYKKRRKKLAP HHHHHHHHHHHHHHH | 43.83 | 6566535 | |
| 949 (in isoform 3) | Phosphorylation | - | 19.33 | 29895711 | |
| 949 (in isoform 2) | Phosphorylation | - | 19.33 | 29895711 | |
| 957 | Phosphorylation | CMQNGEKSPRDPWQE HHHCCCCCCCCCCCC | 22.36 | 20139300 | |
| 978 | Phosphorylation | EHLPEDESEDEESEE CCCCCCCCCCCCCCC | 63.77 | 22802335 | |
| 983 | Phosphorylation | DESEDEESEEGLPSG CCCCCCCCCCCCCCC | 38.61 | 22802335 | |
| 1070 | Phosphorylation | KLGIRPPSSGQETFW HCCCCCCCCCCCCEE | 50.19 | 23140645 | |
| 1071 | Phosphorylation | LGIRPPSSGQETFWR CCCCCCCCCCCCEEE | 50.71 | 22817900 | |
| 1075 | Phosphorylation | PPSSGQETFWRIPAK CCCCCCCCEEECCCC | 22.17 | 23140645 | |
| 1084 | Phosphorylation | WRIPAKLSSTQLRRV EECCCCCCHHHHHHH | 30.54 | 23140645 | |
| 1085 | Phosphorylation | RIPAKLSSTQLRRVA ECCCCCCHHHHHHHH | 30.52 | 23140645 | |
| 1086 | Phosphorylation | IPAKLSSTQLRRVAA CCCCCCHHHHHHHHH | 28.39 | 23140645 | |
| 1132 | Phosphorylation | EALRALLSARKRKAG HHHHHHHHHHHHHCC | 27.20 | 27149854 | |
| 1165 | Phosphorylation | KKRQLLDSDEEEDDE HHHHCCCCCCCCCHH | 47.06 | 27087446 | |
| 1165 (in isoform 6) | Phosphorylation | - | 47.06 | 24453211 | |
| 1178 (in isoform 6) | Phosphorylation | - | 4.03 | 25338131 | |
| 1179 | Phosphorylation | EGRRQAVSGTPRVHR HHHHHHHCCCCCCCC | 39.71 | 29514104 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TIM_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TIM_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TIM_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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