CDC16_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDC16_MOUSE
• UniProt AC: Q8R349
• Protein Name: Cell division cycle protein 16 homolog
• Gene Name: Cdc16
• Organism: Mus musculus (Mouse).
• Sequence Length: 620
• Protein Description: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)..
• Protein Sequence: MNLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDILDMEEPINRRLFEKYLKDDNGSRDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLDSLPLNKLCAEEQELLRFVFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFRDFEVEKQNTEEAGLAPLQNSTKAPESRPNLEETFEIEMNESDMMLETSMSDHST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
133	S-nitrosocysteine	SSIKSSICLLRGKIY HHHHHHHHHHHCCHH	2.94	-
133	S-nitrosylation	SSIKSSICLLRGKIY HHHHHHHHHHHCCHH	2.94	21278135
192	Ubiquitination	LDSLPLNKLCAEEQE HHCCCHHHHCHHHHH	53.26	-
431	Ubiquitination	WFLDALEKIKAIGNE HHHHHHHHHHHHCCC	50.81	-
490	Phosphorylation	SAIGYIHSLMGNFEN HHHHHHHHHHCCHHH	15.53	-
501	Phosphorylation	NFENAVDYFHTALGL CHHHHHHHHHHHHCC	7.23	-
504	Phosphorylation	NAVDYFHTALGLRRD HHHHHHHHHHCCCCC	17.43	-
530	Phosphorylation	IEMYIGDSEAYIGAD EEEEECCCCEEECCC	20.93	26160508
533	Phosphorylation	YIGDSEAYIGADIKD EECCCCEEECCCHHH	8.88	26160508
543	Ubiquitination	ADIKDKLKCYDFDVH CCHHHHHEEECCCHH	36.17	-
553	Ubiquitination	DFDVHTMKTLKNIIS CCCHHHHHHHHHHCC	52.43	-
560	Phosphorylation	KTLKNIISPPWDFRD HHHHHHCCCCCCHHC	22.55	24925903
587	Phosphorylation	LAPLQNSTKAPESRP CCCCCCCCCCCCCCC	38.48	25338131
599	Phosphorylation	SRPNLEETFEIEMNE CCCCHHHHEEEEECH	19.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDC16_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
560	S	Phosphorylation	Phosphorylation on Ser-560 occurs specifically during mitosis (By similarity).	21183079

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDC16_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC20_HUMAN	CDC20	physical	20360068
MD2L1_HUMAN	MAD2L1	physical	20360068
APC13_HUMAN	ANAPC13	physical	20360068
BUB1B_HUMAN	BUB1B	physical	20360068
APC10_HUMAN	ANAPC10	physical	20360068
APC11_HUMAN	ANAPC11	physical	20360068
APC7_HUMAN	ANAPC7	physical	20360068
APC5_HUMAN	ANAPC5	physical	20360068
APC16_HUMAN	ANAPC16	physical	20360068
FBX5_HUMAN	FBXO5	physical	20360068
APC1_HUMAN	ANAPC1	physical	20360068
CDC23_HUMAN	CDC23	physical	20360068
HOME3_HUMAN	HOMER3	physical	20360068
NEK2_HUMAN	NEK2	physical	20360068
CDC16_HUMAN	CDC16	physical	20360068
APC4_HUMAN	ANAPC4	physical	20360068
CDC26_HUMAN	CDC26	physical	20360068
ANC2_HUMAN	ANAPC2	physical	20360068
CDC27_HUMAN	CDC27	physical	20360068
FZR1_HUMAN	FZR1	physical	20360068
HOME1_HUMAN	HOMER1	physical	20360068
BASI_HUMAN	BSG	physical	26496610
BUB1B_HUMAN	BUB1B	physical	26496610
CDC20_HUMAN	CDC20	physical	26496610
CDC27_HUMAN	CDC27	physical	26496610
VKGC_HUMAN	GGCX	physical	26496610
JARD2_HUMAN	JARID2	physical	26496610
MD2L1_HUMAN	MAD2L1	physical	26496610
NDUB4_HUMAN	NDUFB4	physical	26496610
NEK2_HUMAN	NEK2	physical	26496610
CDK17_HUMAN	CDK17	physical	26496610
P5CR1_HUMAN	PYCR1	physical	26496610
RIR2_HUMAN	RRM2	physical	26496610
TAP2_HUMAN	TAP2	physical	26496610
CUL1_HUMAN	CUL1	physical	26496610
CDC23_HUMAN	CDC23	physical	26496610
HOME3_HUMAN	HOMER3	physical	26496610
SCAM3_HUMAN	SCAMP3	physical	26496610
TBB3_HUMAN	TUBB3	physical	26496610
APC10_HUMAN	ANAPC10	physical	26496610
MON2_HUMAN	MON2	physical	26496610
APC13_HUMAN	ANAPC13	physical	26496610
APC15_HUMAN	ANAPC15	physical	26496610
CLIC4_HUMAN	CLIC4	physical	26496610
FBX5_HUMAN	FBXO5	physical	26496610
ANC2_HUMAN	ANAPC2	physical	26496610
P5CR2_HUMAN	PYCR2	physical	26496610
APC4_HUMAN	ANAPC4	physical	26496610
FZR1_HUMAN	FZR1	physical	26496610
APC5_HUMAN	ANAPC5	physical	26496610
APC7_HUMAN	ANAPC7	physical	26496610
T161A_HUMAN	TMEM161A	physical	26496610
CFA97_HUMAN	CFAP97	physical	26496610
APC1_HUMAN	ANAPC1	physical	26496610
GNPTA_HUMAN	GNPTAB	physical	26496610
GHC1_HUMAN	SLC25A22	physical	26496610
CCD82_HUMAN	CCDC82	physical	26496610
WLS_HUMAN	WLS	physical	26496610
YIPF5_HUMAN	YIPF5	physical	26496610
KI18A_HUMAN	KIF18A	physical	26496610
GNPTG_HUMAN	GNPTG	physical	26496610
ERI1_HUMAN	ERI1	physical	26496610
APC16_HUMAN	ANAPC16	physical	26496610
CDC26_HUMAN	CDC26	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.