NRDC_MOUSE - dbPTM
NRDC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NRDC_MOUSE
UniProt AC Q8BHG1
Protein Name Nardilysin
Gene Name Nrdc {ECO:0000250|UniProtKB:O43847}
Organism Mus musculus (Mouse).
Sequence Length 1161
Subcellular Localization
Protein Description Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs..
Protein Sequence MLRRVAVAAVCVTGRKLRCEAGRELTALGRIEARGLCEESSKPFPTLTMPGRNKAKSTCSCPDLQPNGQDLGESGRLARLGADESEEEGRSFSNVGDPEIIKSPSDPKQYRYIKLQNGLQALLISDLSNVEGKTGNATDEEEEEEEEEEEEDDDDDDDDDDDDEDSGAEIQDDDEEGFDDEEEFDDDDDDEHDDDDLENEENELEELEERVEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFSHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRVFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGRCDLKEKWFGTQYSIEDIENSWTELWKSNFDLNPDLHLPAENKYIATDFTLKAFDCPETEYPAKIVNTAQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLTEFSSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYSRWSMIDKYQALMDGLSLDSLLNFVKDFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFAPLEREMPVQFQVVELPSGHHLCKVRALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSETVDKKIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVSWFKAHRGPGSKMLSVHVVGYGKYELEEDGAPFGEDSNSREGMQLTYLPPSPVLAESTTPITDIRAFTATLSLFPYHKIVK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
57PhosphorylationPGRNKAKSTCSCPDL
CCCCCCCCCCCCCCC		39.2325619855
58PhosphorylationGRNKAKSTCSCPDLQ
CCCCCCCCCCCCCCC		14.0225619855
59GlutathionylationRNKAKSTCSCPDLQP
CCCCCCCCCCCCCCC		5.2124333276
60PhosphorylationNKAKSTCSCPDLQPN
CCCCCCCCCCCCCCC		28.8625619855
61GlutathionylationKAKSTCSCPDLQPNG
CCCCCCCCCCCCCCC		3.1024333276
85PhosphorylationARLGADESEEEGRSF
CCCCCCCCHHCCCCC		51.3527087446
91PhosphorylationESEEEGRSFSNVGDP
CCHHCCCCCCCCCCH		43.8325266776
93PhosphorylationEEEGRSFSNVGDPEI
HHCCCCCCCCCCHHH		31.6727180971
103PhosphorylationGDPEIIKSPSDPKQY
CCHHHCCCCCCHHHH		21.1623984901
105PhosphorylationPEIIKSPSDPKQYRY
HHHCCCCCCHHHHHE		73.8923984901
268SuccinylationNGFDAFLKKHGGSDN
CCHHHHHHHCCCCCC		35.9526388266
268AcetylationNGFDAFLKKHGGSDN
CCHHHHHHHCCCCCC		35.9524062335
337UbiquitinationRPSDANRKEMLFGSL
CCCCCCHHHHHHHHC		47.48-
433PhosphorylationHLTDPFDTPAFNKLY
CCCCCCCCHHHHHHE		19.5219854140
640PhosphorylationLKEKWFGTQYSIEDI
CCHHHCCCCEEHHHH		18.1726643407
642PhosphorylationEKWFGTQYSIEDIEN
HHHCCCCEEHHHHHH		16.0826643407
643PhosphorylationKWFGTQYSIEDIENS
HHCCCCEEHHHHHHH		15.0826643407
685GlutathionylationFTLKAFDCPETEYPA
CEEEEECCCCCCCCH		2.3724333276
705UbiquitinationAQGCLWYKKDNKFKI
CCCCEEEEECCCCCC		41.91-
752PhosphorylationHNLAEPAYEADVAQL
CCCCCCHHHCCHHHH		23.51-
761PhosphorylationADVAQLEYKLVAGEH
CCHHHHHHEEHHCCC		20.43-
891UbiquitinationFLKYVVDKLNFAPLE
HHHHHHHHCCCCCCC		33.45-
935PhosphorylationNSEVTVYYQSGTRSL
CCEEEEEEECCCCCH		7.5828576409
966UbiquitinationCFDFLRTKQTLGYHV
HHHHHHCCCCCCCEE		34.55-
1076UbiquitinationEALKSFSKSDLVSWF
HHHHCCCHHHHHHHH		46.08-
1077PhosphorylationALKSFSKSDLVSWFK
HHHCCCHHHHHHHHH		34.6721454597
1091PhosphorylationKAHRGPGSKMLSVHV
HHHCCCCCCEEEEEE		20.3021454597
1095PhosphorylationGPGSKMLSVHVVGYG
CCCCCEEEEEEEEEE		13.4828059163
1131PhosphorylationQLTYLPPSPVLAEST
ECEECCCCCCCCCCC		26.2125338131
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NRDC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NRDC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NRDC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NRDC_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NRDC_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85, AND MASSSPECTROMETRY.

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