SC23B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC23B_MOUSE
• UniProt AC: Q9D662
• Protein Name: Protein transport protein Sec23B {ECO:0000305}
• Gene Name: Sec23b {ECO:0000312|MGI:MGI:1350925}
• Organism: Mus musculus (Mouse).
• Sequence Length: 767
• Subcellular Localization: Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol .
• Protein Description: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex..
• Protein Sequence: MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAILNPLCQVDYRAKLWACNFCFQRNQFPPAYAGISEVNQPAELMPQFSTIEYMIQRGARSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSCEGISKSYVFRGTKDLTAKQIQEMLGLTKSAMPVQQARPAQPQEQPFVSSRFLQPIHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVALSIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKTPIRSWHDIEKDNARFMKKATKHYEMLANRTATNGHCIDIYACALDQTGLLEMKCCPNLTGGHMVMGDSFNTSLFKQTFQRIFSKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWKICGLDPSSTLGIYFEVVNQHNAPVPQGGRGAIQFVTQYQHSSTQKRIRVTTIARNWADAQSQLRHIEAAFDQEAAAVLMARLGVFRAESEEGPDVLRWLDRQLIRLCQKFGQYNKEDPTSFRLSDSFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFARQDLTQSLIMIQPILYSYSFHGPPEPVLLDSSSILADRILLMDTFFQIVIYLGETIAQWRKAGYQDMPEYENFKHLLQAPLDDAQEILQARFPMPRYINTEHGGSQARFLLSKVNPSQTHNNLYAWGQETGAPILTDDVSLQVFMDHLKKLAVSSAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATYLEFIQ ------CCCHHHHHH	12.64	-
40	S-palmitoylation	RMVVPLACLLTPLKE HHHHHHHHHHHCCCC	4.16	28526873
180	Glutathionylation	VQVHELSCEGISKSY EEEEEEEECCCCHHH	9.68	24333276
187	Phosphorylation	CEGISKSYVFRGTKD ECCCCHHHEECCCCC	13.82	24719451
198	Ubiquitination	GTKDLTAKQIQEMLG CCCCCCHHHHHHHHC	42.57	-
208	Ubiquitination	QEMLGLTKSAMPVQQ HHHHCCCCCCCCHHH	41.06	-
309	Ubiquitination	MVVGDELKTPIRSWH EECCCCCCCCCCCHH	50.65	-
310	Phosphorylation	VVGDELKTPIRSWHD ECCCCCCCCCCCHHH	36.25	19060867
314	Phosphorylation	ELKTPIRSWHDIEKD CCCCCCCCHHHHHHH	29.49	22324799
320	Acetylation	RSWHDIEKDNARFMK CCHHHHHHHHHHHHH	57.53	23954790
320	Ubiquitination	RSWHDIEKDNARFMK CCHHHHHHHHHHHHH	57.53	-
393	Phosphorylation	QTFQRIFSKDFNGDF HHHHHHHCCCCCCCE	29.01	24719451
407	Phosphorylation	FRMAFGATLDVKTSR EEEHEECEEECCCCC	24.70	28059163
558	Ubiquitination	QLIRLCQKFGQYNKE HHHHHHHHHCCCCCC	50.93	-
564	Acetylation	QKFGQYNKEDPTSFR HHHCCCCCCCCCCEE	59.57	23806337
564	Ubiquitination	QKFGQYNKEDPTSFR HHHCCCCCCCCCCEE	59.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC23B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC23B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC23B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SC23B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.