| UniProt ID | APC5_MOUSE | |
|---|---|---|
| UniProt AC | Q8BTZ4 | |
| Protein Name | Anaphase-promoting complex subunit 5 | |
| Gene Name | Anapc5 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 740 | |
| Subcellular Localization | ||
| Protein Description | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).. | |
| Protein Sequence | MMTNGVVHANLFGIKDWVTPYKIAVLVLLNEMGRTGEGAVSLVERRKLNQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMDREDGEKQMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQAALLKNDETKALTPASLQKELNNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAEGKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRADSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLESLNAGVQQNNTESFAVALCHLAELHAEQGCFAAAGEVLKHLKDRFPPNSQHAQLWMLCDQKIQFDRAMNDGKFHLADSLVTGITALNGIEGVYRKAVVLQAQNQMTEAHKLLQKLLTYCQKLKNTEMVISVLLSVAELYWRSSSPTIAMPVLLEALALSKEYRLQYLASETVLNLAYAQLILGIPEQALTLLHMAIEPILADGAVLDKGRAMFLVSKCQVASAASYDPVKKAEALEAAIQNLSEAKNYFAQVDCRERIRDVAYFQARLYHALGKTQERNHCAMIFRQLHQELPAHGVPLINHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 47 | Ubiquitination | VSLVERRKLNQLLLP HHHHHHHHHHHHHHH | 58.99 | - | |
| 65 | Ubiquitination | GPDITLSKLYKLIEE CCCCHHHHHHHHHHH | 59.97 | - | |
| 180 | Phosphorylation | EKEELDVSVREEEVS HHHHHCCHHHHHHCC | 18.34 | 26824392 | |
| 187 | Phosphorylation | SVREEEVSCSGPLSQ HHHHHHCCCCCCCCH | 13.07 | 27841257 | |
| 209 | Ubiquitination | SQQAALLKNDETKAL HHHHHHHCCCCHHCC | 64.30 | - | |
| 217 | Phosphorylation | NDETKALTPASLQKE CCCHHCCCHHHHHHH | 22.97 | 26745281 | |
| 220 | Phosphorylation | TKALTPASLQKELNN HHCCCHHHHHHHHHH | 32.32 | 28066266 | |
| 223 | Ubiquitination | LTPASLQKELNNLLK CCHHHHHHHHHHHHH | 70.26 | - | |
| 274 | Ubiquitination | ILTGAEGKSNGEEGY HHCCCCCCCCCCCCC | 32.05 | - | |
| 349 | Phosphorylation | SYVLLEHSVKKAVHF CHHHHHHHHHHHHHC | 26.68 | - | |
| 388 | Ubiquitination | NKLMDALKDSDLLHW HHHHHHHCCCCCHHH | 57.83 | - | |
| 390 | Phosphorylation | LMDALKDSDLLHWKH HHHHHCCCCCHHHCC | 28.68 | - | |
| 398 | Phosphorylation | DLLHWKHSLSELIDI CCHHHCCCHHHHHHH | 29.84 | - | |
| 400 | Phosphorylation | LHWKHSLSELIDISI HHHCCCHHHHHHHHH | 33.11 | - | |
| 406 | Phosphorylation | LSELIDISIAQKTAI HHHHHHHHHHHHHHH | 14.23 | - | |
| 509 | Ubiquitination | DRAMNDGKFHLADSL HHHHCCCCCCHHHHH | 32.26 | - | |
| 562 | Phosphorylation | YCQKLKNTEMVISVL HHHHCCCHHHHHHHH | 24.70 | 23140645 | |
| 571 | Phosphorylation | MVISVLLSVAELYWR HHHHHHHHHHHHHHH | 18.34 | 23140645 | |
| 706 | Phosphorylation | AYFQARLYHALGKTQ HHHHHHHHHHHCCCC | 4.58 | 28066266 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of APC5_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of APC5_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of APC5_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| BUB1B_HUMAN | BUB1B | physical | 20360068 | |
| CDC16_HUMAN | CDC16 | physical | 20360068 | |
| CDC23_HUMAN | CDC23 | physical | 20360068 | |
| CDC27_HUMAN | CDC27 | physical | 20360068 | |
| APC5_HUMAN | ANAPC5 | physical | 20360068 | |
| APC1_HUMAN | ANAPC1 | physical | 20360068 | |
| CDC26_HUMAN | CDC26 | physical | 20360068 | |
| APC4_HUMAN | ANAPC4 | physical | 20360068 | |
| CDC20_HUMAN | CDC20 | physical | 20360068 | |
| APC7_HUMAN | ANAPC7 | physical | 20360068 | |
| ANC2_HUMAN | ANAPC2 | physical | 20360068 | |
| ABL1_HUMAN | ABL1 | physical | 26496610 | |
| CDC27_HUMAN | CDC27 | physical | 26496610 | |
| M3K3_HUMAN | MAP3K3 | physical | 26496610 | |
| CDC23_HUMAN | CDC23 | physical | 26496610 | |
| CDC16_HUMAN | CDC16 | physical | 26496610 | |
| ANC2_HUMAN | ANAPC2 | physical | 26496610 | |
| WDR33_HUMAN | WDR33 | physical | 26496610 | |
| APC1_HUMAN | ANAPC1 | physical | 26496610 | |
| FIP1_HUMAN | FIP1L1 | physical | 26496610 | |
| APC16_HUMAN | ANAPC16 | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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