RFC1_MOUSE - dbPTM
RFC1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RFC1_MOUSE
UniProt AC P35601
Protein Name Replication factor C subunit 1
Gene Name Rfc1
Organism Mus musculus (Mouse).
Sequence Length 1131
Subcellular Localization Nucleus.
Protein Description The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction..
Protein Sequence MDIRKFFGVISSGKKPVNETVKNEKTKASEGTVKGKKGVKEAKVNNSGKEDASKPKQHSKKKRIIYDSDSESEETVQVKNAKKKSEKLSLSYKPGKVSQKDPVTYVSETDEDDDFVCKKAASKSKENGVSTNSYLGTSNVKKNEENVKTKNKPLSPIKLTPTSVLDYFGTESVQRSGKKMVTSKRKESSQNTEDSRLNDEAIAKQLQLDEDAELERQLHEDEEFARTLALLDEEPKIKKARKDSEEGEESFSSVQDDLSKAEKQKSPNKAELFSTARKTYSPAKHGKGRASEDAKQPCKSAHRKEACSSPKASAKLALMKAKEESSYNETELLAARRKESATEPKGEKTTPKKTKVSPTKRESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLTFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKILDEDGLLDLIRTMPGKRSKYEMAAEAEMKKEKSKLERTPQKNDQGKRKISPAKKESESKKCKLTLLKNSPMKAVKKEASTCPRGLDVKETHGNRSSNKEECLLWVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAAKFGKLASKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTSGAAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQSKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGEETAHMSLMDKSDLFFHDYSIAPLFVQENYLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSLLPTQAIYASVLPGELMRGYMTQFPSFPSWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTVNMDYLSHIRDALVRPLTSQGVEGAQHVIKLMDTYYLMKEDFENIMEVSSWGGKPSAFSKLDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSTGPALDSEYSEEFQEDDTQSEKEQDAVETDAMIKKKTRSSKPSKSEREKESKKGKGKNWKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationRKFFGVISSGKKPVN
HHHHHHCCCCCCCCC		30.5428066266
12PhosphorylationKFFGVISSGKKPVNE
HHHHHCCCCCCCCCH		43.4328066266
20PhosphorylationGKKPVNETVKNEKTK
CCCCCCHHHHCCCCC		31.4128066266
66PhosphorylationSKKKRIIYDSDSESE
CCCCEEEECCCCCCC		13.6623684622
68PhosphorylationKKRIIYDSDSESEET
CCEEEECCCCCCCCC		26.5127087446
70PhosphorylationRIIYDSDSESEETVQ
EEEECCCCCCCCCEE		47.1527087446
72PhosphorylationIYDSDSESEETVQVK
EECCCCCCCCCEEEC		44.6927087446
75PhosphorylationSDSESEETVQVKNAK
CCCCCCCCEEECCCC		16.5225619855
91PhosphorylationKSEKLSLSYKPGKVS
HHCCCCCCCCCCCCC		27.9529176673
98PhosphorylationSYKPGKVSQKDPVTY
CCCCCCCCCCCCCCE		34.6925619855
104PhosphorylationVSQKDPVTYVSETDE
CCCCCCCCEEECCCC		24.4825521595
105PhosphorylationSQKDPVTYVSETDED
CCCCCCCEEECCCCC		11.3827742792
107PhosphorylationKDPVTYVSETDEDDD
CCCCCEEECCCCCCC		25.1027087446
109PhosphorylationPVTYVSETDEDDDFV
CCCEEECCCCCCCCC		36.8625521595
130PhosphorylationKSKENGVSTNSYLGT
CCHHCCCCCCCCCCC		24.2221659604
131PhosphorylationSKENGVSTNSYLGTS
CHHCCCCCCCCCCCC		26.2721659604
133PhosphorylationENGVSTNSYLGTSNV
HCCCCCCCCCCCCCC		23.0921659604
134PhosphorylationNGVSTNSYLGTSNVK
CCCCCCCCCCCCCCC		15.9521659604
137PhosphorylationSTNSYLGTSNVKKNE
CCCCCCCCCCCCCCH		17.9621659604
138PhosphorylationTNSYLGTSNVKKNEE
CCCCCCCCCCCCCHH		37.5221659604
155PhosphorylationKTKNKPLSPIKLTPT
CCCCCCCCCCCCCCC		32.8626824392
160PhosphorylationPLSPIKLTPTSVLDY
CCCCCCCCCCCHHHH		21.3721082442
162PhosphorylationSPIKLTPTSVLDYFG
CCCCCCCCCHHHHHC		26.6525619855
163PhosphorylationPIKLTPTSVLDYFGT
CCCCCCCCHHHHHCC		23.1425619855
167PhosphorylationTPTSVLDYFGTESVQ
CCCCHHHHHCCHHHH		10.3525619855
170PhosphorylationSVLDYFGTESVQRSG
CHHHHHCCHHHHHHC		18.3925619855
172PhosphorylationLDYFGTESVQRSGKK
HHHHCCHHHHHHCCE		24.3226745281
176PhosphorylationGTESVQRSGKKMVTS
CCHHHHHHCCEECCC		37.5629514104
188PhosphorylationVTSKRKESSQNTEDS
CCCCCHHHCCCCCCC		40.0125266776
189PhosphorylationTSKRKESSQNTEDSR
CCCCHHHCCCCCCCC		28.6527841257
192PhosphorylationRKESSQNTEDSRLND
CHHHCCCCCCCCCCH		33.2724719451
195PhosphorylationSSQNTEDSRLNDEAI
HCCCCCCCCCCHHHH		32.2230635358
244PhosphorylationIKKARKDSEEGEESF
HHHHHCCCHHHHHHH		40.3527087446
250PhosphorylationDSEEGEESFSSVQDD
CCHHHHHHHHHHHHH		26.5727742792
252PhosphorylationEEGEESFSSVQDDLS
HHHHHHHHHHHHHHH		38.5925168779
253PhosphorylationEGEESFSSVQDDLSK
HHHHHHHHHHHHHHH		23.0621082442
259PhosphorylationSSVQDDLSKAEKQKS
HHHHHHHHHHHHHCC		36.4925619855
266PhosphorylationSKAEKQKSPNKAELF
HHHHHHCCCCHHHHH		31.0726824392
274PhosphorylationPNKAELFSTARKTYS
CCHHHHHHHHHHHCC		33.5125777480
275PhosphorylationNKAELFSTARKTYSP
CHHHHHHHHHHHCCC		24.1325777480
281PhosphorylationSTARKTYSPAKHGKG
HHHHHHCCCCCCCCC		24.5024453211
308PhosphorylationAHRKEACSSPKASAK
HHHHHHHCCHHHHHH		57.6423684622
309PhosphorylationHRKEACSSPKASAKL
HHHHHHCCHHHHHHH		30.2424453211
349PhosphorylationTEPKGEKTTPKKTKV
CCCCCCCCCCCCCCC		43.9925266776
350PhosphorylationEPKGEKTTPKKTKVS
CCCCCCCCCCCCCCC		44.1526824392
354PhosphorylationEKTTPKKTKVSPTKR
CCCCCCCCCCCCCCC		42.6919854140
357PhosphorylationTPKKTKVSPTKRESV
CCCCCCCCCCCCCCC		28.5421149613
359PhosphorylationKKTKVSPTKRESVSP
CCCCCCCCCCCCCCH		34.9221149613
363PhosphorylationVSPTKRESVSPEDSE
CCCCCCCCCCHHHHH		31.7425521595
365PhosphorylationPTKRESVSPEDSEKK
CCCCCCCCHHHHHHH		31.6725521595
369PhosphorylationESVSPEDSEKKRTNY
CCCCHHHHHHHHHHH		50.0528833060
376PhosphorylationSEKKRTNYQAYRSYL
HHHHHHHHHHHHHHH		8.2329514104
382PhosphorylationNYQAYRSYLNREGPK
HHHHHHHHHCCCCCC		10.0529514104
504PhosphorylationEKSKLERTPQKNDQG
HHHHHHCCCCCCHHC		22.2425159016
512AcetylationPQKNDQGKRKISPAK
CCCCHHCCCCCCCCC		44.902372955
516PhosphorylationDQGKRKISPAKKESE
HHCCCCCCCCCCHHC		23.1129895711
524PhosphorylationPAKKESESKKCKLTL
CCCCHHCCCCCEEEE		46.85-
535PhosphorylationKLTLLKNSPMKAVKK
EEEECCCCCCHHHHH		25.4526824392
750PhosphorylationKIRSLVHYCFDLRFQ
HHHHHHHHHHHCCCC		6.32-
977PhosphorylationRTYSSKRTVNMDYLS
CCCCCCCEECHHHHH		21.7028973931
995PhosphorylationDALVRPLTSQGVEGA
HHHHHHCHHCCCHHH		22.99-
1070PhosphorylationVVKTSRLSTGPALDS
EEECCCCCCCCCCCC		30.1525619855
1071PhosphorylationVKTSRLSTGPALDSE
EECCCCCCCCCCCCH		52.3425619855
1077PhosphorylationSTGPALDSEYSEEFQ
CCCCCCCCHHHHHHH		39.0125619855
1079PhosphorylationGPALDSEYSEEFQED
CCCCCCHHHHHHHCC		25.9025619855
1080PhosphorylationPALDSEYSEEFQEDD
CCCCCHHHHHHHCCC		26.9725619855
1088PhosphorylationEEFQEDDTQSEKEQD
HHHHCCCCCCHHHHH		46.4425619855
1090PhosphorylationFQEDDTQSEKEQDAV
HHCCCCCCHHHHHHH		53.3725521595
1099PhosphorylationKEQDAVETDAMIKKK
HHHHHHHHHHHHHHH		23.5925619855
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RFC1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RFC1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RFC1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RFC1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RFC1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68; SER-70; SER-107;THR-109 AND SER-244, AND MASS SPECTROMETRY.

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