dbPTM

REPS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	REPS1_MOUSE
UniProt AC	O54916
Protein Name	RalBP1-associated Eps domain-containing protein 1
Gene Name	Reps1
Organism	Mus musculus (Mouse).
Sequence Length	795
Subcellular Localization	Membrane, clathrin-coated pit. Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits..
Protein Description	May coordinate the cellular actions of activated EGF receptors and Ral-GTPases..
Protein Sequence	MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRLAASYSSDSENQGSYSGVIPPPPGRGQVKKGPGSHDAVQPRPSAEQQEPVSPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLTGPGPFWSPFGDAQAGSSAGDAVWSGQSPPPPQDNWVSFADTPPTSALLTMHPASVQDQTTVRTVASAATANEIRRQSSSYEDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGEQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTSSDHTNPTSPLLVKPSDLSEENKINSSVKFPSGNTVDGYSSSDSFPSDPEQIGSSVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFAVTTGQQQAGVVAHPPAVPPRPQPSQAPGPSVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVSEEQDSEAEKHPEVLPAEKASDPSSSLRAAQADSKAEEKTATNVPANVSKGTTPLAPPPKPVRRRLKSEDELRPDVDEHTQKTGVLAAVLTSQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	PLPRFVASKNEQESR CCCEEECCCCHHHHH	30.61	25266776
115	Phosphorylation	QESRLAASYSSDSEN HHHHHHHHCCCCCCC	21.68	26745281
116	Phosphorylation	ESRLAASYSSDSENQ HHHHHHHCCCCCCCC	13.89	25521595
117	Phosphorylation	SRLAASYSSDSENQG HHHHHHCCCCCCCCC	25.77	26745281
118	Phosphorylation	RLAASYSSDSENQGS HHHHHCCCCCCCCCC	36.60	27087446
120	Phosphorylation	AASYSSDSENQGSYS HHHCCCCCCCCCCCC	40.16	26745281
125	Phosphorylation	SDSENQGSYSGVIPP CCCCCCCCCCCCCCC	13.32	26745281
126	Phosphorylation	DSENQGSYSGVIPPP CCCCCCCCCCCCCCC	19.10	25777480
127	Phosphorylation	SENQGSYSGVIPPPP CCCCCCCCCCCCCCC	28.42	25777480
145	Phosphorylation	QVKKGPGSHDAVQPR CCCCCCCCCCCCCCC	22.71	29472430
154	Phosphorylation	DAVQPRPSAEQQEPV CCCCCCCCHHHCCCC	45.80	23429704
162	Phosphorylation	AEQQEPVSPVVSPQQ HHHCCCCCCCCCCCC	23.77	27742792
166	Phosphorylation	EPVSPVVSPQQSPPT CCCCCCCCCCCCCCC	19.75	27742792
170	Phosphorylation	PVVSPQQSPPTSPHT CCCCCCCCCCCCCCC	27.83	26824392
173	Phosphorylation	SPQQSPPTSPHTWRK CCCCCCCCCCCCCCC	59.27	27742792
174	Phosphorylation	PQQSPPTSPHTWRKH CCCCCCCCCCCCCCC	22.06	27742792
177	Phosphorylation	SPPTSPHTWRKHSRH CCCCCCCCCCCCCCC	30.28	29899451
186	Phosphorylation	RKHSRHPSGGNSERP CCCCCCCCCCCCCCC	53.89	20415495
190	Phosphorylation	RHPSGGNSERPLTGP CCCCCCCCCCCCCCC	37.95	28066266
220	Phosphorylation	AGDAVWSGQSPPPPQ CCCCCCCCCCCCCCC	19.10	17242355
258	O-linked_Glycosylation	QDQTTVRTVASAATA CCCHHHHHHHHHHHH	18.98	55413547
258	Phosphorylation	QDQTTVRTVASAATA CCCHHHHHHHHHHHH	18.98	23984901
261	Phosphorylation	TTVRTVASAATANEI HHHHHHHHHHHHHHH	17.69	22942356
264	Phosphorylation	RTVASAATANEIRRQ HHHHHHHHHHHHHHC	29.72	23984901
272	Phosphorylation	ANEIRRQSSSYEDPW HHHHHHCCCCCCCCC	21.31	25521595
273	Phosphorylation	NEIRRQSSSYEDPWK HHHHHCCCCCCCCCC	28.71	25521595
274	Phosphorylation	EIRRQSSSYEDPWKI HHHHCCCCCCCCCCC	37.48	27087446
275	Phosphorylation	IRRQSSSYEDPWKIT HHHCCCCCCCCCCCC	26.71	27087446
282	Phosphorylation	YEDPWKITDEQRQYY CCCCCCCCHHHHHHH	29.74	25266776
288	Phosphorylation	ITDEQRQYYVNQFKT CCHHHHHHHHHCCCC	16.15	-
307	Phosphorylation	LNGFIPGSAAKEFFT CCCCCCCHHHHHHHH	21.50	-
347 (in isoform 3)	Phosphorylation	-	2.14	25338131
349 (in isoform 3)	Phosphorylation	-	2.40	27180971
351 (in isoform 3)	Phosphorylation	-	5.55	27180971
354 (in isoform 3)	Phosphorylation	-	45.01	26643407
358 (in isoform 3)	Phosphorylation	-	58.08	26643407
365 (in isoform 3)	Phosphorylation	-	67.93	26643407
366 (in isoform 3)	Phosphorylation	-	28.20	26643407
369 (in isoform 3)	Phosphorylation	-	33.33	26643407
377	Phosphorylation	KLIDLEDSADVGEQP HHCCHHHCCCCCCCC	19.59	28066266
389	Phosphorylation	EQPGEVGYSGSPAEA CCCCCCCCCCCCCCC	18.29	24925903
390	Phosphorylation	QPGEVGYSGSPAEAP CCCCCCCCCCCCCCC	27.19	25521595
392	Phosphorylation	GEVGYSGSPAEAPPS CCCCCCCCCCCCCCC	18.26	24925903
399	Phosphorylation	SPAEAPPSKSPSMPS CCCCCCCCCCCCCCC	44.71	24925903
401	Phosphorylation	AEAPPSKSPSMPSLN CCCCCCCCCCCCCHH	26.92	21183079
403	Phosphorylation	APPSKSPSMPSLNQT CCCCCCCCCCCHHHC	50.87	21743459
406	Phosphorylation	SKSPSMPSLNQTWPE CCCCCCCCHHHCCHH	31.17	21743459
428	Phosphorylation	WETFSERSSSSQTLT HHHHHHHCCCCCCEE	30.44	26643407
429	Phosphorylation	ETFSERSSSSQTLTQ HHHHHHCCCCCCEEC	39.98	26643407
430	Phosphorylation	TFSERSSSSQTLTQF HHHHHCCCCCCEECC	27.93	26643407
431	Phosphorylation	FSERSSSSQTLTQFD HHHHCCCCCCEECCC	29.18	26643407
433	Phosphorylation	ERSSSSQTLTQFDSN HHCCCCCCEECCCCC	33.45	26643407
435	Phosphorylation	SSSSQTLTQFDSNIA CCCCCCEECCCCCCC	30.49	26643407
439	Phosphorylation	QTLTQFDSNIAPADP CCEECCCCCCCCCCC	31.27	25293948
448	Phosphorylation	IAPADPDTAIVHPVP CCCCCCCCCEEECCC	24.54	26745281
459	Phosphorylation	HPVPIRMTPSKIHMQ ECCCCCCCCCHHHHC	17.98	26745281
461	Phosphorylation	VPIRMTPSKIHMQEM CCCCCCCCHHHHCEE	34.77	25266776
462	Acetylation	PIRMTPSKIHMQEME CCCCCCCHHHHCEEE	37.52	7627581
473	Phosphorylation	QEMELKRTSSDHTNP CEEEECCCCCCCCCC	30.87	27742792
474	Phosphorylation	EMELKRTSSDHTNPT EEEECCCCCCCCCCC	37.49	27742792
475	Phosphorylation	MELKRTSSDHTNPTS EEECCCCCCCCCCCC	32.57	27742792
478	Phosphorylation	KRTSSDHTNPTSPLL CCCCCCCCCCCCCCE	48.13	27742792
481	Phosphorylation	SSDHTNPTSPLLVKP CCCCCCCCCCCEECH	45.08	27742792
482	Phosphorylation	SDHTNPTSPLLVKPS CCCCCCCCCCEECHH	18.14	26824392
489	Phosphorylation	SPLLVKPSDLSEENK CCCEECHHHCCCCCC	45.53	25619855
492	Phosphorylation	LVKPSDLSEENKINS EECHHHCCCCCCCCC	48.10	25619855
499	Phosphorylation	SEENKINSSVKFPSG CCCCCCCCCCCCCCC	39.73	25777480
500	Phosphorylation	EENKINSSVKFPSGN CCCCCCCCCCCCCCC	25.49	25777480
505	Phosphorylation	NSSVKFPSGNTVDGY CCCCCCCCCCCCCCC	48.05	25293948
508	Phosphorylation	VKFPSGNTVDGYSSS CCCCCCCCCCCCCCC	24.41	25293948
509	Phosphorylation	KFPSGNTVDGYSSSD CCCCCCCCCCCCCCC	6.61	19144319
512	Phosphorylation	SGNTVDGYSSSDSFP CCCCCCCCCCCCCCC	10.83	25293948
513	Phosphorylation	GNTVDGYSSSDSFPS CCCCCCCCCCCCCCC	28.97	25293948
514	Phosphorylation	NTVDGYSSSDSFPSD CCCCCCCCCCCCCCC	29.67	25293948
515	Phosphorylation	TVDGYSSSDSFPSDP CCCCCCCCCCCCCCH	31.19	25293948
517	Phosphorylation	DGYSSSDSFPSDPEQ CCCCCCCCCCCCHHH	40.79	25293948
520	Phosphorylation	SSSDSFPSDPEQIGS CCCCCCCCCHHHCCC	64.88	25293948
534	Phosphorylation	SSVTRQRSHSGTSPD CCHHCCCCCCCCCCC	17.42	27087446
536	Phosphorylation	VTRQRSHSGTSPDNT HHCCCCCCCCCCCCC	45.04	27087446
538	Phosphorylation	RQRSHSGTSPDNTAP CCCCCCCCCCCCCCC	39.85	27087446
539	Phosphorylation	QRSHSGTSPDNTAPP CCCCCCCCCCCCCCC	33.51	23684622
543	Phosphorylation	SGTSPDNTAPPPPPP CCCCCCCCCCCCCCC	48.17	23684622
555	Phosphorylation	PPPRPQPSHSRSSSL CCCCCCCCCCCCCCC	28.93	23684622
557	Phosphorylation	PRPQPSHSRSSSLDM CCCCCCCCCCCCCCC	37.89	23684622
559	Phosphorylation	PQPSHSRSSSLDMNR CCCCCCCCCCCCCCC	27.56	27087446
560	Phosphorylation	QPSHSRSSSLDMNRT CCCCCCCCCCCCCCE	33.53	22324799
561	Phosphorylation	PSHSRSSSLDMNRTF CCCCCCCCCCCCCEE	29.63	25521595
656	Phosphorylation	EKHPEVLPAEKASDP HHCCCCCCHHHCCCC	43.48	19144319
666	Phosphorylation	KASDPSSSLRAAQAD HCCCCCHHHHHHHHC	26.64	22006019
689	Phosphorylation	TNVPANVSKGTTPLA CCCCCCCCCCCCCCC	25.77	25338131
692	Phosphorylation	PANVSKGTTPLAPPP CCCCCCCCCCCCCCC	29.04	28066266
693	Phosphorylation	ANVSKGTTPLAPPPK CCCCCCCCCCCCCCC	25.60	28066266
708	Phosphorylation	PVRRRLKSEDELRPD CCHHCCCCCCCCCCC	55.67	26824392
720	Phosphorylation	RPDVDEHTQKTGVLA CCCCCHHHHHHCHHH	29.70	25619855
723	Phosphorylation	VDEHTQKTGVLAAVL CCHHHHHHCHHHHHH	23.78	25777480
731	Phosphorylation	GVLAAVLTSQPSIPR CHHHHHHCCCCCCCC	20.79	23984901
732	Phosphorylation	VLAAVLTSQPSIPRS HHHHHHCCCCCCCCC	35.61	26239621
735	Phosphorylation	AVLTSQPSIPRSVGK HHHCCCCCCCCCCCC	37.27	26824392
739	Phosphorylation	SQPSIPRSVGKDKKA CCCCCCCCCCCCHHH	29.84	26643407
745	Malonylation	RSVGKDKKAIQASIR CCCCCCHHHHHHHHH	61.94	26320211
745	Succinylation	RSVGKDKKAIQASIR CCCCCCHHHHHHHHH	61.94	24315375
750	Phosphorylation	DKKAIQASIRRNKET CHHHHHHHHHHCCHH	10.55	25338131
755	Acetylation	QASIRRNKETNTVLA HHHHHHCCHHHHHHH	65.19	22902405
757	Phosphorylation	SIRRNKETNTVLARL HHHHCCHHHHHHHHH	37.49	26643407
759	Phosphorylation	RRNKETNTVLARLNS HHCCHHHHHHHHHHH	25.06	26643407
766	Phosphorylation	TVLARLNSELQQQLK HHHHHHHHHHHHHHH	44.25	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of REPS1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of REPS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of REPS1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of REPS1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of REPS1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561 AND SER-708, ANDMASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186 AND SER-708, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-272, AND MASSSPECTROMETRY.	17242355 [Abstract]