F10A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F10A1_MOUSE
• UniProt AC: Q99L47
• Protein Name: Hsc70-interacting protein
• Gene Name: St13
• Organism: Mus musculus (Mouse).
• Sequence Length: 371
• Subcellular Localization: Cytoplasm.
• Protein Description: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity)..
• Protein Sequence: MDPRKVSELRAFVKMCRQDPSVLHTEEMRFLREWVESMGGKVPPATHKAKSEENTKEEKRDKTTEENIKTEELSSEESDLEIDNEGVIEPDTDAPQEMGDENAEITEEMMDEANEKKGAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLREVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHERAQREEEARRQSGSQYGSFPGGFPGGMPGNFPGGMPGMGGAMPGMAGMAGMPGLNEILSDPEVLAAMQDPEVMVAFQDVAQNPSNMSKYQSNPKVMNLISKLSAKFGGQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Malonylation	SELRAFVKMCRQDPS HHHHHHHHHHHCCCC	26.31	26320211
14	Ubiquitination	SELRAFVKMCRQDPS HHHHHHHHHHHCCCC	26.31	-
74	Phosphorylation	NIKTEELSSEESDLE HHHHHHHCCCCCCCC	38.70	29899451
75	Phosphorylation	IKTEELSSEESDLEI HHHHHHCCCCCCCCC	58.99	29899451
78	Phosphorylation	EELSSEESDLEIDNE HHHCCCCCCCCCCCC	43.36	29899451
117	Malonylation	MDEANEKKGAAIEAL HHHHHHHCCHHHHHC	47.83	26320211
117	Ubiquitination	MDEANEKKGAAIEAL HHHHHHHCCHHHHHC	47.83	-
141	Ubiquitination	DLFTDAIKLNPRLAI HHHHHHHHHCHHHHH	43.88	-
152	Ubiquitination	RLAILYAKRASVFVK HHHHHHHHHCCEEEE	34.63	-
152	Malonylation	RLAILYAKRASVFVK HHHHHHHHHCCEEEE	34.63	26320211
152	Succinylation	RLAILYAKRASVFVK HHHHHHHHHCCEEEE	34.63	23806337
152	Acetylation	RLAILYAKRASVFVK HHHHHHHHHCCEEEE	34.63	22826441
155	Phosphorylation	ILYAKRASVFVKLQK HHHHHHCCEEEECCC	21.81	23684622
159	Malonylation	KRASVFVKLQKPNAA HHCCEEEECCCCCHH	33.46	26320211
159	Ubiquitination	KRASVFVKLQKPNAA HHCCEEEECCCCCHH	33.46	-
159	Acetylation	KRASVFVKLQKPNAA HHCCEEEECCCCCHH	33.46	21728379
162	Ubiquitination	SVFVKLQKPNAAIRD CEEEECCCCCHHHCC	51.15	27667366
170	Glutathionylation	PNAAIRDCDRAIEIN CCHHHCCCCCCEECC	2.47	24333276
180	Phosphorylation	AIEINPDSAQPYKWR CEECCCCCCCCCCCC	30.02	25338131
185	Ubiquitination	PDSAQPYKWRGKAHR CCCCCCCCCCCHHHH	36.78	27667366
185	Acetylation	PDSAQPYKWRGKAHR CCCCCCCCCCCHHHH	36.78	23236377
208	S-nitrosocysteine	AHDLALACKLDYDED HHHHHHHHCCCCCHH	4.71	-
208	Glutathionylation	AHDLALACKLDYDED HHHHHHHHCCCCCHH	4.71	24333276
208	S-palmitoylation	AHDLALACKLDYDED HHHHHHHHCCCCCHH	4.71	28680068
208	S-nitrosylation	AHDLALACKLDYDED HHHHHHHHCCCCCHH	4.71	20925432
217	Phosphorylation	LDYDEDASAMLREVQ CCCCHHHHHHHHHHH	26.91	24759943
348	Phosphorylation	AQNPSNMSKYQSNPK HHCCCCHHHHHCCHH	32.25	-
349	Ubiquitination	QNPSNMSKYQSNPKV HCCCCHHHHHCCHHH	36.22	-
352	Phosphorylation	SNMSKYQSNPKVMNL CCHHHHHCCHHHHHH	52.59	-
355	Acetylation	SKYQSNPKVMNLISK HHHHCCHHHHHHHHH	59.37	23806337
355	Ubiquitination	SKYQSNPKVMNLISK HHHHCCHHHHHHHHH	59.37	27667366
361	Phosphorylation	PKVMNLISKLSAKFG HHHHHHHHHHHHHHC	30.61	26643407
362	Acetylation	KVMNLISKLSAKFGG HHHHHHHHHHHHHCC	39.19	23806337
362	Ubiquitination	KVMNLISKLSAKFGG HHHHHHHHHHHHHCC	39.19	27667366
364	Phosphorylation	MNLISKLSAKFGGQS HHHHHHHHHHHCCCC	32.90	26643407
366	Ubiquitination	LISKLSAKFGGQS-- HHHHHHHHHCCCC--	40.96	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
348	S	Phosphorylation	Kinase	GRK5	Q8VEB1	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F10A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F10A1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of F10A1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.