| UniProt ID | U520_MOUSE | |
|---|---|---|
| UniProt AC | Q6P4T2 | |
| Protein Name | U5 small nuclear ribonucleoprotein 200 kDa helicase | |
| Gene Name | Snrnp200 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 2136 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (By similarity).. | |
| Protein Sequence | MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDMNKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRREIDLLLGQTDDTRYHVLVNLGKKITDYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEPEKERIVGKMEADPELSKFLYQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGGHNYTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MADVTARSLQYEYKA CCCCCHHHHHEEECC | 29514104 | ||
| 17 | Phosphorylation | QYEYKANSNLVLQAD HEEECCCCCEEEEEC | 20415495 | ||
| 26 | Phosphorylation | LVLQADRSLIDRTRR EEEEECHHHHHCCCC | 25266776 | ||
| 46 | Ubiquitination | EVLSLVGKLEGTRMG HHHHHHHHHHCCCCC | 22790023 | ||
| 83 | Acetylation | EDRHDMNKMKGYTLL HHHHHHHHHHHHHHH | 7718163 | ||
| 207 | Phosphorylation | GVNVQFESDEEEGDE CEEEEEECCCCCCCC | 25195567 | ||
| 217 | Phosphorylation | EEGDEDVYGEVREEA CCCCCCCHHHHHCCC | 21149613 | ||
| 225 | Phosphorylation | GEVREEASDDDMEGD HHHHCCCCCCCCCCC | 27087446 | ||
| 273 | Phosphorylation | FWLQRQLSRFYDDAI HHHHHHHHHHHHHHH | 25338131 | ||
| 330 | Phosphorylation | QHRMMILYCTLLASA HHHHHHHHHHHHHHC | 26643407 | ||
| 332 | Phosphorylation | RMMILYCTLLASAQS HHHHHHHHHHHHCCC | 26643407 | ||
| 336 | Phosphorylation | LYCTLLASAQSEPEK HHHHHHHHCCCCHHH | 26643407 | ||
| 339 | Phosphorylation | TLLASAQSEPEKERI HHHHHCCCCHHHHHH | 26643407 | ||
| 358 | Ubiquitination | EADPELSKFLYQLHE HCCHHHHHHHHHHHH | 22790023 | ||
| 368 | Acetylation | YQLHETEKEDLIREE HHHHHHHHHHHHHHH | 23806337 | ||
| 368 | Ubiquitination | YQLHETEKEDLIREE HHHHHHHHHHHHHHH | 22790023 | ||
| 385 | Phosphorylation | RRERVRQSRMDTDLE HHHHHHHHHCCCCCC | 25338131 | ||
| 389 | Phosphorylation | VRQSRMDTDLETMDL HHHHHCCCCCCCCCC | 25338131 | ||
| 457 | Phosphorylation | LKPKPFGSEEQLLPV CCCCCCCCHHHCCCH | 26824392 | ||
| 466 | Ubiquitination | EQLLPVEKLPKYAQA HHCCCHHHCHHHHHH | 22790023 | ||
| 469 | Ubiquitination | LPVEKLPKYAQAGFE CCHHHCHHHHHHCCC | 22790023 | ||
| 469 | Acetylation | LPVEKLPKYAQAGFE CCHHHCHHHHHHCCC | 22826441 | ||
| 479 | Ubiquitination | QAGFEGFKTLNRIQS HHCCCHHHHHHHHHH | 22790023 | ||
| 557 | Ubiquitination | EMVGSFGKRLATYGI HHHHHHHHHHHHHCE | 22790023 | ||
| 709 | Phosphorylation | QIMNEIVYEKIMEHA HHHHHHHHHHHHHHC | - | ||
| 729 | Acetylation | LVFVHSRKETGKTAR EEEEECCCCCCHHHH | 134131 | ||
| 733 | Acetylation | HSRKETGKTARAIRD ECCCCCCHHHHHHHH | 2383407 | ||
| 770 | Ubiquitination | RTEAEQCKNLELKDL HHHHHHHCCCCHHHH | 22790023 | ||
| 795 | Phosphorylation | GMTRVDRTLVEDLFA CCCCCCCHHHHHHHC | 22802335 | ||
| 944 | Ubiquitination | GISHDDLKGDPLLDQ CCCHHHCCCCCCCCH | 22790023 | ||
| 971 | Acetylation | LDKNNLVKYDKKTGN HCCCCCEEEECCCCC | - | ||
| 975 | Ubiquitination | NLVKYDKKTGNFQVT CCEEEECCCCCEEEE | 22790023 | ||
| 1028 | Phosphorylation | SSEFKNITVREEEKL CHHHCCCCCCHHHHH | 19854140 | ||
| 1039 | Ubiquitination | EEKLELQKLLERVPI HHHHHHHHHHHCCCC | 22790023 | ||
| 1049 | Ubiquitination | ERVPIPVKESIEEPS HCCCCCCCCCCCCCC | 22790023 | ||
| 1134 | Ubiquitination | CPLRQFRKLPEEVVK CCHHHHHCCCHHHHH | 22790023 | ||
| 1173 | Phosphorylation | RMPKMGKTIHKYVHL CCCCCCCCHHHHHHH | - | ||
| 1177 | Phosphorylation | MGKTIHKYVHLFPKL CCCCHHHHHHHHHCC | - | ||
| 1315 | Phosphorylation | PVSALRNSAFESLYQ CHHHHHCHHHHHHHC | 28066266 | ||
| 1319 | Phosphorylation | LRNSAFESLYQDKFP HHCHHHHHHHCCCCC | 28066266 | ||
| 1404 | Ubiquitination | FQDRLNKKVVLLTGE HHHHHCCCEEEEECC | 22790023 | ||
| 1421 | Ubiquitination | TDLKLLGKGNIIIST CCEEECCCCCEEEEC | 27667366 | ||
| 1428 | Phosphorylation | KGNIIISTPEKWDIL CCCEEEECHHHHHHH | 22006019 | ||
| 1452 | Ubiquitination | VQNINLFVVDEVHLI CCCEEEEEEEEEEEC | 27667366 | ||
| 1541 | Phosphorylation | HTQTRLLSMAKPVYH HHHHHHHHHHHHHHH | 22871156 | ||
| 1595 | Ubiquitination | RFLHCTEKDLIPYLE HHHCCCHHHHHHHHH | 22790023 | ||
| 1595 | Acetylation | RFLHCTEKDLIPYLE HHHCCCHHHHHHHHH | 22826441 | ||
| 1603 | Ubiquitination | DLIPYLEKLSDSTLK HHHHHHHHCCCCHHH | 22790023 | ||
| 1605 | Phosphorylation | IPYLEKLSDSTLKET HHHHHHCCCCHHHHH | 28285833 | ||
| 1607 | Phosphorylation | YLEKLSDSTLKETLL HHHHCCCCHHHHHHH | 27841257 | ||
| 1765 | Phosphorylation | TFLYRRMTQNPNYYN HHHHHHHCCCCCCCC | 17525332 | ||
| 1917 | Phosphorylation | SDTEEILSKAIRLIQ CCHHHHHHHHHHHHH | 23737553 | ||
| 1961 | Ubiquitination | WSKDSYLKQLPHFTS HCCCHHHHHCCCCCH | 22790023 | ||
| 2002 | Phosphorylation | ALLQLTDSQIADVAR HHHHCCHHHHHHHHH | - | ||
| 2059 | Ubiquitination | IAPLFPQKREEGWWV EECCCCCCCCCCEEE | 27667366 | ||
| 2090 | Ubiquitination | TLQQKAKVKLDFVAP ECHHCCCEEEEEEEC | 27667366 | ||
| 2131 | Phosphorylation | VDVKEAETDSDSD-- EEHHHCCCCCCCC-- | 23429704 | ||
| 2133 | Phosphorylation | VKEAETDSDSD---- HHHCCCCCCCC---- | 23429704 | ||
| 2135 | Phosphorylation | EAETDSDSD------ HCCCCCCCC------ | 23429704 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of U520_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of U520_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of U520_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of U520_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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